Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Nanotherapeutics"”.
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Dendrimer Based Nanotherapeutics For Ocular Drug Delivery
<p>PAMAM dendrimers are a class of well-defined, hyperbranched polymeric nanocarriers that are being investigated for ocular drug and gene delivery. Their favorable properties such as small size, multivalency and water solubility can provide significant opportunities for many biologically unstable …
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Beta-Lapachone Nanotherapeutics for Lung Cancer Therapy
A rising trend in lung cancer chemotherapy involves the development of agents that exploit molecular targets overexpressed in tumors, with hopes of increasing specificity, and in turn, efficacy. β-Lapachone (β-lap) is a novel anticancer drug whose mechanism of action relies on its bioactivation by …
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Development of orthogonal nanotherapeutics for colorectal cancer treatment
The tumour suppressor p53 has an impressive ability to regulate multiple cellular events such as apoptosis and cell cycle. Strategies aimed at activating the wild-type p53 convene a great therapeutic potential. This led to the discovery of the small molecule inhibitors, MDM2 antagonists which …
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Multistage nanoparticle delivery system for deep penetration into solid tumor and electrically controlled catalytic nanowire growth
… into solid tumors. Current FDA-approved nanotherapeutics, which function based on the enhanced permeation and retention (EPR) effect, suffer from poor penetration into the extravascular regions of the tumor due to the dense collagen matrix, resulting in heterogeneous therapeutic effects …
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In vitro investigation of the anticancer activity and molecular mechanisms of action of albumin nano-encapsulated copper/zinc diethyldithiocarbamate in human pancreatic cancer cells
… highlights Alb-CuDDC and Alb-ZnDDC as promising nanotherapeutics for PDAC. However, the resistance profile of Alb-ZnDDC underscores the superior therapeutic potential of Alb-CuDDC. Moreover, the identification of CST1 provides insight into resistance mechanisms and highlights potential targets …
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A microfluidic platform for combinatorial synthesis and optimization of targeted polymeric nanoparticles for cancer therapy
… among other diseases. Although a myriad of nanotherapeutics have been developed at the bench side, many of them stay at the research stage due to their complexity and difficulty in their optimization. A key challenge for optimization of nanoparticles (NPs) for drug delivery is the ability to …
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Design and development of polymeric nanoparticles by continuous manufacture using twin screw extrusion
… within the field with the global market value of nanotherapeutics projected to be worth US$369.5 Billion by 2027 (Research and Market, 2020). Despite this, there is a significant lack of nanoparticles in the clinic; the ability to produce polymeric nanoparticles, reproducibly, and on a large scale …
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Critical considerations in development of mesoporous silica nanoparticles for biological applications.
… redispersible, and small mesoporous silica nanotherapeutics. This chapter discusses the particle stability of bare and modified mesoporous silica in various biological media. Critical synthetic parameters including introduction of hydrophilic and hydrophobic organosilanes and hydrothermal …
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Differential Autophagic Responses to Nano-Sized Materials
… of AAV-based gene delivery systems as well as nanotherapeutics for the treatment of diseases characterized by insufficient autophagic clearance. Titanium dioxide nanoparticles of different primary particle diameters were found to induce transcriptional upregulation of the lysosome-autophagy …
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Synthesis, Functionalization, and Characterization of Dominant UV Emitting Upconverting Nanocrystals and Absolute Quantum Yield and Power Dependence Metrics for the Elucidation of Upconversion Mechanisms
… equivalent metrics and utility in cancer nanotherapeutics), assessment, and readdressing of, as yet undiscovered limits to these materials are presented.</p>
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Aib(2)oxyntomodulin Peptide Molecular Self-Assembly: Smart Nanostructures Toward Long Acting Formulation for Obesity and Diabetes Type 2
Type 2 diabetes mellitus (T2DM) and obesity are the most prevalent metabolic complications in the world. Previous studies have revealed that dual agonist gut hormone, oxyntomodulin (Oxm), has a promising beneficial role to treat obesity and T2DM through suppressing the food intake, raising the …