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Showing 1 to 15 of 15 for “"Nanopore Sensing"”.
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Single-Molecule Characterization of RNA via Nanopore Sensing
… followed by characterization via solid-state nanopore sensing. I first describe the nanopore observables and nucleic acid parameters relevant to nanostructure characterization. Then, I demonstrate how tandem implementation of nanostructure engineering and nanopore sensing can be used to size …
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Applications of nanopore sensing and DNA nanotechnology for the analysis of nucleic acids
Nanopore sensing is a versatile technology for biomolecule analysis based on resistive pulse sensing. It includes biological nanopores, primarily used for long-read direct sequencing, and solid-state nanopores, which have been applied to biosensing molecules such as proteins, RNA, and DNA. While …
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Decoding the Fabric of Life: Nanopore Sensing of Nucleic Acid Structure from the Primary to the Quaternary
… leveraged RNA/DNA nanotechnology and solid-state nanopore sensing to detect RNA structural modifications and to characterise the kinetics of nanostructure formation. Additionally, I aimed to directly identify triplexes solely using nanopore sensing. The group’s RNA Single-nucleotide …
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Advanced nucleic acid detection with solid-state nanopores: from fundamental understanding to cutting-edge platforms
Solid-state glass nanopore sensing has emerged as a powerful technique for single molecule detection, due to its operational simplicity, high sensitivity, and real-time analytical capability. Despite these advantages, significant challenges remain in achieving multiplexed detection of diverse …
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Ion current modulation in bio-mimetic channel systems
… the modulation of ionic current is a signal for nanopore sensing. Here, several simulation studies focusing on ion channel conductance modulation and nanopore sensing are presented. Specifically, comprehensive research on a designed bio-mimetic channel can lead to the ionic current modulation by …
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Investigating the parameters affecting the sensitivity of a protein nanopore sensor
<p>In the last three decades nanopore sensing has emerged as a powerful technique for DNA sequencing and bio-molecular sensing. One of the great appeals of this technique is that it usually does not require any labeling or chemical modification. Additionally, its ability to examine a single …
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Nanopore-based Protein Sensing with DNA Nanostructures
… two decades ago, scientists created the first nanopore- an α-hemolysin channel inserted into a lipid bilayer separating two buffered KCl-filled compartments. Today, nanopores are often associated with sequencing – likely due to the immense success of companies like Oxford Nanopore Technologies. …
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Detection of Nucleic Acid Disease Biomarkers Using Solid-State Nanopores
Nanopore sensing technology was initiated with the ultimate goal of developing a rapid, single-molecule sequencer. With the release of Oxford Nanopore Technology’s Minion sensor in 2014, that goal has been achieved. While this device utilizes biological nanopores, Solid-State Nanopore sensors were …
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Biomolecular transport at and through two-dimensional materials
… electrical conductivity enables potential nanopore sensing applications for controllable nanofluidics and nanopore sensing applications conducive towards biomolecule sequencing. A nanopore sequencer operates by recording the ionic current as a single-stranded DNA molecule is …
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Molecular Sensing with Protein and Solid-State Nanopores
<p>In the past 15 years nanopore sensing has proven to be a successful method for probing a variety of molecules of biological interest, such as DNA, RNA and proteins. Of particular appeal is this technique's ability to probe these molecules without the need for chemical modification or labeling, …
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Stability and bandwidth investigation of alternative structures for nanopore sensors
… the most promising technologies among these is nanopore sequencing. Nanopore sequencing involves the threading of a DNA molecule between two electrolytic reservoirs through a nanometer-sized pore on a synthetic or an organic platform by means of electrophoresis and/or mag- netism. During the …
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Nanopore-Based Readout of Encoded DNA Nanostructures
Nanopore sensing is a powerful technique for the detection and study of single molecules. The underlying resistive pulse principle relies on molecules modulating an ionic current as they pass through a nanoscale constriction between two reservoirs. The technique has recently been extended to the …
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Computational modeling of DNA and protein sensing via nanopore systems
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
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Electronic current modeling in solid-state nanochannels and applications
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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Quantum transport in graphene nanotransistors
… of graphene nanoribbon transistors, with nanopores, to electronically detect, characterize, and manipulate translocating DNA strands. Specifically, we explore the tunability of such devices, by examining the role of lattice geometry, such as a quantum point contact constriction, on their …