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Showing 1 to 8 of 8 for “"Nanomicelles"”.
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Caractérisation de nanomicelles d’huile essentielle-surfactant pour le développement d’un désinfectant vert et biodégradable
… vert et potentiellement biodégradable à base de nanomicelles d’huiles essentielles aux propriétés antimicrobiennes, a été proposé pour la désinfection de surfaces et le traitement des eaux industrielles. Cette formulation présente le potentiel d’éliminer les microorganismes pathogènes, tout en …
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Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents
PART I: SELF-ASSEMBLING TACROLIMUS NANOMICELLES FOR BACK OF THE EYE DISEASES Vrinda Gote, Candidate for the Doctor of Philosophy Degree University of Missouri-Kansas City, 2021 ABSTRACT Neovascular age-related macular degeneration (AMD) is characterized by increase in reactive oxygen species (ROS) …
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Novel Folic Acid Targeted Nanomicelles For Delivery Of Hydrophobic Drugs To The Back Of The Eye
… project is to develop folic acid targeted nanomicelles loaded with insoluble hydrophobic drugs for delivery to posterior segment of the eye. Retinoblastoma and uveitis are diseases that affect the posterior segment. Etoposide (ET) is used for treatment of retinoblastoma and fluocinolone …
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Preparation of Pentablock Nanomicellar Formulations for Prostate Cancer Drug Delivery Systems
… Specific aim #2 focused on: (i) preparation of nanomicelles with polymers synthesized in specific aim 1, loading hydrophobic paclitaxel drug or hydrophobic ion pairing complex(HIP) of doxorubicin molecules, and characterizing them for shape, size and polydispersity indices, (ii) conjugation of a …
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Part I: Effect of Nanomicelle Size on Trans-scleral Permeability of Dexamethasone and Part II: Strategies to Minimize Octreotide Acylation during Sustained Release from Biodegradable Polymers
… dexamethasone (DEX) transport across the sclera. Nanomicelles of various sizes were developed and characterized. Low molecular weight diblock co-polymers, mPEG₇₅₀-PCL₇₀₀ (DB1), mPEG₂₀₀₀-PCL₁₅₀₀ (DB2) and mPEG₅₀₀₀-PCL₄₀₀₀ (DB3) were synthesized by ring opening polymerization. Polymers were …
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Novel nanocarriers to improve drug delivery for age-related macular degeneration
… encapsulated in the hydrophobic core of the nanomicelles with enhanced solubility. Nanomicellar formulations decorated with hyaluronic acid (HA) were utilized as the cellular uptake enhancer in oxaprozin-loaded nanomicelles into retinal cells. These formulations are capable to overcome the …
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Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
… for efflux pumps and prepared resolvin analog nanomicelles. Studies showed that NMFs were tolerable and delivered high drug concentrations to back-of-the-eye tissues with topical eye drop application to rabbits. Negligible drug levels were quantified in systemic circulation. These nanomicellar …
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Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration
… solubilized and entrapped in the core of the nanomicelles. These nanomicellar constructs efficiently utilize their hydrophilic corona and evade the wash-out into the systemic circulation from both the conjunctival and choroidal blood vessels and lymphatics, thus overcoming the dynamic barrier. …