Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Nanomachines"”.
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Synthesis, Monitoring, and Molechanical Action of Light-Driven Motorized Nanomachines
… design and synthesis of a series of unimolecular nanomachines bearing a fast light-driven rotary motor (3 MHz at 25 °C) as a power unit and fluorophores for their monitoring. A well-tailored structural design that unifies the mechanism of propulsion and the requisite monitoring component, made …
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Molecular recognition, in- and out- of equilibrium, in the actions of bacterial multidrug efflux nanomachines
… of a wide family of homologous and analogous nanomachines, including those found in numerous clinically relevant pathogens. The AcrAB-TolC pump spans the cell envelope and is powered by proton gradients across the inner membrane to energise the active efflux of an array of chemically unrelated …
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The Noncontractile Phage Tail-like Bacterial Killing Nanomachines – Characterizing the Specificity Determinants of the F-Pyocins of Pseudomonas aeruginosa
The rise of antibiotic-resistant bacterial strains poses an enormous threat to our collective human existence; hence, there is a dire need to search for alternatives to current antibiotic treatment options. In this work, I characterized the non-contractile phage tail-like entities called F-pyocins. …
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Artificial and natural nucleic acid self assembling systems
… catalysts. However, to use nucleic acids as nanomachines, a better understanding of their material properties, how to design structures using them, and their dynamics is needed. We have tried to address these issues, in a small way, with nucleic acid force field development, an attempt at …
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Dynamic Plasmonic Systems with Actuating Nanotransducers
The development of programmable nanomachines that deliver therapeutic drugs to specific target sites, assemble objects, or work together to apply coherent forces on-demand has been long sought after in the field of nanotechnology. A major hurdle in this endeavour is the lack of a reliable source of …
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The application of GPU to molecular communication studies
… possibilities of futuristic in vivo nanomachines. Existing MC simulations have not fully accounted for structural boundaries and the associated simulation of a massive number of messenger molecule paths for stochastic evaluation. These molecules are influenced by a Brownian motion as …
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DNA Origami Mechanisms and Machines
… design and assembly of higher order controllable nanomachines. This work has the potential of initiating a new era of nanorobot design useful for applications including drug delivery, biosensing, and nanomanufacturing.
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DNA Constraints for Rational Control of Macromolecular Conformation
… DNA, proteins, or nanoparticles, and dynamic DNA nanomachines have been built. However, assemblies in which DNA controls the intramolecular states of other macromolecules are rare. In this thesis, short (10--20 bp) DNA duplexes are used as structural constraints to control RNA conformation. Based …
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Development of track-walking DNA nanomotors
… effects and are adaptable for use in other nanomachines.
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Mutational and molecular analyses of lactococcal bacteriophages TP901-1 and Tuc2009
… as extremely efficient bacterium-infecting nanomachines. The Siphoviridae phages TP901-1 and Tuc2009 infect Lactococcus lactis, and both belong to the so-called P335 species. As P335 phages are typically capable of a lytic and lysogenic life cycle, a number of molecular tools are available …
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Interferometric Scattering Microscopy: Theory, Simulation, and Experiment
… including pioneering research into DNA origami nanomachines.
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Nano/Bio-Receiver Architectures and Detection Methods for Molecular Communications
… with collaborative networks of artificial nanomachines and biological entities integrated into the Internet. To enable the IoNT and its groundbreaking applications, such as real-time intrabody health monitoring, it is imperative to devise nanoscale communication techniques with …
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Characterisation of the structure and function of the Salmonella flagellar export gate protein, FlhB.
… bacterial cell surface, illustrate how complex nanomachines assemble outside the cell. The sequential construction of the flagellar rod, hook, and filament requires export of thousands of structural subunits across the cell membrane and this is achieved by a specialised flagellar Type III …
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Single-molecule studies of protein degradation and kinesin-8 motility
… bigger protein families, these two fascinating nanomachines perform important cellular tasks in protein quality control and spindle formation, respectively. AAA+ ClpX unfoldases use energy from ATP binding and hydrolysis to drive mechanical unfolding and translocation of target proteins to …