Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Nanofiber scaffolds"”.
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Evaluation of methods to account for release from nanofiber scaffolds
… form fibers from the micro- to nanometer range. Nanofibers form through electrospinning can be utilized as scaffolds since the fiber structures are similar to the structures within the extracellular matrix. Researchers use additives, such as growth factors, to help facilitate cell proliferation …
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Fabrication of nanofiber scaffolds by electrospinning and it's potential for tissue engineering
… is adapted to produce tissue-engineering scaffolds of two different size ranges composed of non-woven poly-L-lactide (PLLA) nanofibers and as a first study, the potential use of these scaffolds as tissue engineering scaffolds was assessed with the cell proliferation of Mesenchymal stem …
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A 3-dimensional vascularized cardiac tri-culture model using chitosan nanofiber scaffolds
… and characterize a biodegradable chitosan nanofiber scaffold that would resemble the extracellular matrix (ECM) physically and chemically. Chitosan, a natural polysaccharide that shares structural homology to the ECM glycosaminoglycans was processed into nanofibers via electrospinning to …
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Investigation of adipose-derived mesenchymal stem cells interaction with electrospun demineralized bone matrix nanofiber scaffolds
Nanofiber demineralized bone matrix (DBM) scaffolds were fabricated by electrospinning, and their ability to support cell adhesion and cell viability of murine adipose-derived mesenchymal stem cells (AD-MSCs) for short-term in culture media was investigated. Poly (ε-caprolactone) (PCL) scaffolds …
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Development of 3-d liver model for drug screening applications
… (3-D) liver model using chitosan-based nanofiber scaffolds and co-culture system (adult rat hepatocytes and 3T3-J2 fibroblasts) to mimic the natural liver and to justify its application for in vitro drug screening. Chitosan nanofiber scaffolds were fabricated by electrospinning …
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Thermal and morphological analysis of collagen-plla electrospun blends
… and Poly (L-lactic acid) produces blended nanofiber scaffolds that may have application in tissue engineering, wound dressing and drug delivery. The goal of this research work was to produce and characterize blended nanofibers of a protein, collagen, and a synthetic polymer, poly (L-lactic …
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A self-assembling peptide scaffold functionalized for use with neural stem cells
… of these functionalized self-assembling peptide scaffolds when used for the culture of neural stem cells, and to characterize these newly developed materials for comparison with RADA16. The effect of the functional motifs on the structure of the peptide scaffold was evaluated with circular …
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A Microfludic Assay Device for Study of Cell Migration on ECM-mimicking Suspended Nanofibers in Presence of Biochemical Cues
… chemotaxis on aligned, suspended ECM-mimicking nanofibers. The device is comprised of a network of microfluidic mixing channels which produce a temporally invariant, linear chemical gradient over nanofiber scaffolds in an observation channel. The microfluidic device design was guided by a …
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Homing and Differentiation of Mesenchymal Stem Cells in 3D In Vitro Models
… of exogenous MSCs via injection or cell-laden scaffolds and through mobilization and migration of endogenous MSCs to injury sites. MSC fate and function is determined by microenvironmental cues, specifically dimensionality, topography, and cell-cell interactions. MSC responses of migration and …
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Bioresorbable Electrospun Tissue Scaffolds of Poly(ethylene glycol-b-lactide) Copolymers for Bone Tissue Engineering
… but biocompatibility issues still exist. Tissue scaffolds fabricated from these materials by current methods have biocompatibility limitations because they are chemically and topographically inert to cells. The chemical composition of these scaffolds does not influence cell behavior (i.e. …
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Anti-Inflammatory Effect of Adipose-Derived Mesenchymal Stem Cells for Flexor Tendon Healing
… at the repair site was developed. The fibrin/nanofiber scaffolds were well-tolerated in the in vivo flexor tendon repair setting and successful delivery of ASCs was achieved. Pilot data demonstrated promise with this approach, as demonstrated by down-regulation of IL-1β and MMP1 in the …
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Investigation of Single-Cell and Blood-Brain Barrier Mechanics after Electroporation and in Primary Brain Cancers
… network of extracellular-matrix mimicking nanofibers enabled cell attachment and contraction, resulting in measurable fiber deflections. Cell contractile forces were shown to be temporarily disrupted after reversible electroporation, in an orientation and field-dependent manner. …