Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Nanoconjugates"”.
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Design and Development of Nanoconjugates for Nanotechnology
… well as to do multiplexing, to engineer QD-based nanoconjugates for optical and biomedical applications. Immobilizing luminescent semiconductor CdSe/ZnS QDs to a solid platform for QD-based biosensors offers advantages over traditional solution-based assays. In the first project, we designed …
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Dendrimer Nanoconjugates And Their Oral Inhalation Formulations For Lung Cancer Therapy
<p>Lung cancers are leading cause of cancer death for both men and women in the world. Lungs are also one of the primary organs to which almost all cancer can spread. Chemothepray plays a crucial role in the fight against both primary lung cancers and lung metastases. Doxorubicin (DOX) is a potent …
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Fighting cancer with nanomedicine−drug-polyester nanoconjugates for targeted cancer therapy
… my Ph. D. research is to develop drug-polyester nanoconjugates (NCs) as a novel translational polymeric drug delivery system that can successfully evade non-specific uptake by reticuloendothelial system (RES) and facilitate targeted cancer diagnosis and therapy. By uniquely integrating …
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Novel Biomimetic Polymeric Nanoconjugates as Drug Delivery Carriers for Poorly Soluble Drugs
… formulation of novel amorphous ibuprofen-polymer nanoconjugates based on the polymer-drug complexation in order to improve its physical and dissolution characteristics without the use of toxic organic solvents. Plain and ibuprofen-loaded binary and ternary nanoconjugates were prepared using four …
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Development of polymeric drug delivery vehicles for targeted cancer therapy
… payloads. This thesis introduces the concept of nanoconjugates to overcome difficulties in synthesis and formulation. Drugs with hydroxyl group are able to initiate polyester synthesis in a regio- and chemo- selective way, with the mediation of ligand-tunable Zinc catalyst. Herein, three …
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Mouse Melanoma Model for Evaluating Anti-Cancer Effects of Nanoparticles, Composites and Conjugates
… influence of the host immune response. Specific nanoconjugates, such as ZnO, MnZnS, and ZnONi, tested in both mouse and human melanoma cells showed cancer selectivity, leading to apoptosis in melanoma cells and protection of normal cells in vitro. A dose-response model introducing B16F10 melanoma …
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SYNTHESIS OF NANOCOMPOSITES BY LASER ABLATION
… and the size distribution of the resulting bio-nanoconjugates were examined with UV-Visible spectroscopy (UV-Vis), dynamic light scattering (DLS), and transmission electron microscopy (TEM). These techniques showed that the Au nanoparticles in aqueous solutions were highly monodispersed …
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Investigating the size effect of nanoparticles in Click Chemistry mediated cancer targeting
… sizes (20, 50 and 200 nm). The 20-nm silica nanoconjugates (NCs) were found to have the highest accumulation in the tumour tissue both ex vivo and in vivo. This work provides further insights into the design of nanomedicine for cancer targeting when the targeting is mediated by a …
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Precisely size controlled drug-silica nanoconjugate for cancer therapy
… drug delivery platform based on drug-silica nanoconjugates (drug-NCs) that can be controllably fabricated with nearly any desired sizes between 20 and 200 nm, with extremely narrow particle size distribution (less than 10% coefficient of variation), and 10-20% drug loading and controlled drug …
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Nanoparticle Biofunctionalization for Self-Assembly and Energy Transfer Applications
… between QRs. To incorporate the improved QR/Ppy nanoconjugates into the QD/DNA clusters, the QR emission should be a result of non-radiative energy transfer contributions only to prevent simultaneous excitation of the energy donor and acceptor. To investigate the contribution from radiative …
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Engineering multimodal nanoparticles to combat triple-negative breast cancer
… by other cells in the body. When antibody nanoconjugates bind FZD7 receptors, it prevents their activation by extracellular Wnt ligands, leading to downstream inhibition of the Wnt signaling pathway. As TNBC lacks targeted treatment options, the ability to use FZD7-targeted NPs to …
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Advances in single molecule spectroscopy and microscopy for biological imaging and polymer characterization
… First, we developed fluorescent dendrimer nanoconjugates (FDN) consisting of multiple individual Cy5 dye molecules conjugated to a polymer dendrimer scaffold, which allows for increases in the total brightness of the molecules. In addition, we designed a series of 'self-healing' dendrimers …