Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"NanoDSF"”.
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Reevaluating Chlorotoxin Targets: Insights Into Glioblastoma Cell Migration and Neuropilin-1 Binding
… such as nanoDifferential Scanning Fluorimetry (nanoDSF) and Surface Plasmon Resonance (SPR). These analyses revealed that Ctx and its C-terminal fragments exhibit weak binding to NRP-1 at high micromolar affinities.Additionally, an enzymatic inhibition assay showed that Ctx and its fragments do …
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Small molecule inhibition of immunoregulatory protein-protein interactions
Selective molecular recognition between proteins is a fundamental event in biological processes that governs cellular growth, function, survival, and differentiation. The immune system, for example, is a complex network of cellular processes regulated by protein-protein interactions (PPIs) between …
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Cholesterol Modulation of BK Currents and Cerebral Artery Diameter Via Channel-Forming Alpha-Subunit
<p>Voltage- and calcium-gated, large conductance potassium channels (BK; MaxiK) are ubiquitously expressed and subsequently mediate numerous physiological processes. Cholesterol is consumed in high amounts with the diet and accumulates in cellular membranes when plasma levels become elevated. …