Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Naltrexone"”.
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Anorexigenic effects of naltrexone in rats
… receptor blockers, a non-selective antagonist naltrexone (NTX), has been used in animal and clinical studies related to excessive appetite. Consequently, NTX in combination with another molecule, bupropion, has been approved as a pharmaceutical to treat obesity. This success underscores the …
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Exploring the Pharmacology of (+)-Naltrexone on Alcohol Reward and Anxiety Behaviours
… attenuating TLR4-TRIF signalling via (+)-Naltrexone; reduces behavioural markers of acute alcohol-induced reward such as conditioned place preference and two-bottle choice – an effect dependent on the time-of-day; prevents acute alcohol-induced sensitisation during adolescence and some but …
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THE EFFECT OF NALTREXONE ON NICOTINE-INDUCED CONDITIONED PLACE PREFERENCE IN RATS
… extend these findings to the opioid antagonist naltrexone, which has long been FDA-approved for the treatment of opioid and alcohol addiction in humans. Using standard two-chamber shuttleboxes, we first sought to establish a place preference for nicotine in rats, and once this was achieved, we …
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DESIGN, SYNTHESES, AND BIOLOGICAL EVALUATION OF 14-N-SUBSTITUTED NALTREXONE DERIVATIVES AS OPIOID RECEPTOR LIGANDS
… concept, a series of 14-O-substituted naltrexone derivatives were designed and synthesized. These compounds carried an ester-linked heteroaromatic substitution at the 14-position of naltrexone which was designed to interact with the putative “address” site, that was identified in the mu …
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The effects of Naltrexone on severe self-injurious behavior in inpatient adults with developmental disabilities
… this thesis was to explore the probability that Naltrexone can reduce self-injurious behavior, specifically the frequency, as measured by total number of incidents, and severity, measured by total number of self-inflicted injuries. Naltrexone is a pure opiate antagonist, which internally alters …
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Rapid opioid detoxification with an implementation of the new method of gradually increasing dosage of naltrexone induction /
… of the research is to identify which of the two naltrexone induction techniques during the rapid opioid detoxification procedure evokes a higher stress response and has higher influence on the acute, antagonist-induced opioid withdrawal and its expression of subjective and objective symptoms. …
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A 'Biorelevant' Approach for Accelerated In Vitro Release and In Vitro-In Vivo Relationship of a Biodegradable, Naltrexone Implant
… an effective, long acting delivery system for naltrexone. Accelerated in vitro methods are also important for quality assurance of manufactured dosage forms. For drug release testing of sustained release parenteral dosage forms, the modified USP Apparatus 4 (flow-through cell) has been …
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Ultra-Low Dose Antagonist Effects on Cannabinoids and Opioids in Models of Pain: Is Less More?
… WIN 55 212-2 (WIN), the opioid antagonist naltrexone (an ultra-low or a high dose), or a combination of WIN and naltrexone doses. Ultra-low dose naltrexone elevated WIN-induced tail flick thresholds without extending its duration of action. In experiment 2, antinociception was tested in …
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Opiate Regulation of Lordosis: Neurochemical Evaluation of the Role of Opiate-Serotonergic Interactions
… in the actions of opiates. The opiate antagonist naltrexone was found to facilitate lordosis in estrogen-primed rats. Naltrexone facilitated behavior was compared to the facilitation of behavior by progesterone. The medial preoptic area (POA) was found to be important in the actions of naltrexone. …
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Benzodiazepine and opioid dependence. Clinical and meta-analytical studies.
… 8 RCT were included with 1,511 patients. In the naltrexone study 15 RCT were included with 990 patients. In the methadone review (Paper III) retention in treatment was higher (d=0.90), and opioid abuse and criminality was lower (d=0.61) and (d=0.35) respectively compared to controlled conditions. …
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Understanding ligand binding, selectivity and functions on the G protein-coupled receptors: A molecular modeling approach
… ii) assessment of the selectivity profile of naltrexone derivatives on the three opioid receptors (μ-opioid, κ-opioid, δ-opioid) with an aim towards designing selective μ-opioid receptor antagonists, and iii) structural modeling of the ‘active’ state conformation of the κ-opioid receptor in …
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Greitosios opioidinės detoksikacijos eiga taikant naują palaipsniui didėjančių naltreksono dozių indukcijos metodą /
… of the research is to identify which of the two naltrexone induction techniques during the rapid opioid detoxification procedure evokes a higher stress response and has higher influence on the acute, antagonist-induced opioid withdrawal and its expression of subjective and objective symptoms. …
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Intra-nacc adenosine and its role in mediating palatable food intake: interactions with striatal opioids
… agonist DAMGO or the opiate antagonist naltrexone. The influence of the A1 receptor agonist CCPA, the A1 receptor antagonist DPX, the A2A receptor agonist CGS 21680, and the A2A receptor antagonist MSX-3 on feeding behaviors was investigated. CCPA had no effect on baseline or …
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Opioid regulation of ingestive behavior in the domestic fowl
… of two opioid antagonists, naloxone and naltrexone, were evaluated in Rock-Comish (RC) and Single-Comb White Leghorn (SCWL) cockerels. Naloxone and naltrexone decreased food and water intake in both stocks. In a separate experiment, the effect of naloxone on water intake was evaluated …
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A Systematic Investigation of Whether Cannabinoids and Opioids Interact in the Nucleus Accumbens Shell to Differentially Impact Feeding Patterns on a Palatable Diet
… that both the mu-opioid receptor antagonist naltrexone and the CB1 receptor antagonist rimonabant blocked DAMGO-induced feeding. Taken together, these results imply that the nucleus accumbens shell may be one neural location of the observed synergistic effects of the opioid and cannabinoid …
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An evaluation and comparison of current FDA-approved treatments for obesity
… As a result, liraglutide, lorcaserin, naltrexone/bupropion extended-release, and phentermine/ topiramate extended-release became FDA-approved for long-term treatment of obesity. Each drug acts on a specific part of the CNS to modulate appetite and cause decreased food intake in …
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Assessment of Ethanol and Nicotine Interactions in the Rat Model: Pharmacotherapeutics, Adolescence, and the Mesolimbic System
… Chapter Two investigated the efficacy of naltrexone and varenicline, the pharmacological ‘gold standards’ for treating AUD and nicotine dependence, on voluntary drug intake by rats selectively bred for high EtOH drinking. The results indicated that the standard treatments for AUD and …
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Access to Medication-Assisted Treatment for Opioid Dependence in the United States – Identifying Implications for Policy and Practice
… managing OUD using methadone, buprenorphine, or naltrexone in addition to counseling and behavioral therapy. MAT access is low in the US. This study investigates access to MAT by age group in the US. Its primary aim is to investigate barriers faced by adults diagnosed with OUD in accessing MAT by …
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BIORELEVANT RELEASE TESTING OF LONG-ACTING INJECTABLES INTENDED FOR PARENTERAL ADMINISTRATION
… microspheres loaded with naltrexone or flurbiprofen were used as model delivery systems to investigate the impact of interstitial fluid and extracellular matrix components on release behavior under different hydrodynamic conditions. Biorelevant media were developed based on …
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