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Showing 1 to 11 of 11 for “"Naked mole rats"”.
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Characterisation of Cutaneous Wound Healing Process in Naked Mole Rats
Being the longest-lived rodent, naked mole-rats (NMR; Heterocephalus glaber) are an exceptional model for biogerontological research. However, unlike other rodents, not much is known about their wound healing process. To investigate that, full-thickness wounds were created in the back skin of naked …
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Probing the protein homeostasis mechanisms in long-lived naked mole-rats
The naked mole-rat (NMR) is a fascinating animal which has unique biological features including eusociality, strict subterranean inhabitation and poikilothermy. It is the longest-living rodent, showing negligible senescence over the majority of its lifespan and high resistance to diseases such as …
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Pup ontogeny and factors influencing behavioural and morphological variation in naked mole-rats, Heterocephalus glaber (Rodentia, Bathyergidae)
… study was undertaken on laboratory-reared naked mole-rats. The main objective of the study was to provide a detailed qualitative and quantitative description of the behavioural and morphological development of naked mole-rats from birth through to adulthood. This study laid an empirical …
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The gonadotropin-releasing hormone (GnRH) system: a comparison between breeding and non-breeding naked mole rats (Heterocephalus glaber)
… and without it, reproduction cannot occur. Naked mole rats (Heterocephalus glaber) have a rigid social hierarchy. The "queen" is the most dominant female and is the only female who breeds. All aspects of reproduction are suppressed in other females in the colony: these "subordinates" are in …
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Social suppression of reproduction in the naked mole-rat, Heterocephalus glaber : -Plasma LH concentrations and differential pituitary responsiveness to exogenous GnRH
The naked mole-rat provides possibly the most extreme example of socially-induced reproductive suppression observed in any mammal. The majority of colony members remain reproductively suppressed for their entire lives, nevertheless they are not sterile, and can become reproductively active soon …
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Hormonal aspects of reproductive suppression in the naked mole-rat, Heterocephalus glaber
Subordinate, female naked mole-rats (Heterocephalus g/aber) are anovulatory as a result of extremely low luteinising hormone (LH) levels. Evidence suggests that aggression from the dominant female naked mole-rat directed towards subordinates could produce these lowered levels of LH. This study …
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Mechanisms Underlying Mesenchymal Stem Cell-Derived Extracellular Vesicle Modulation of Sensory Neuron Excitability
… (EVs), which facilitate the transfer of biomolecular cargo between cells. Our previous work demonstrated that MSC-EVs alleviate pain in a murine model of OA by reducing OA-induced sensory neuron hyperexcitability, rather than altering joint pathology. These findings underscore the …
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Functional anatomy, osteogenesis and bone microstructure of the appendicular system of African mole-rats (Rodentia: Ctenohystrica: Bathyergidae)
… aspects, the skeletal system of African mole-rats (Bathyergidae) has been relatively understudied. Only a few studies have assessed their skeletal system, but these have mostly focused on their cranial and dental systems, with little attention on their postcranial skeleton. This PhD …
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Proton-sensing G protein-coupled receptor signalling in inflammation
… is thus considerable interest in elucidating the molecular mechanisms underlying inflammatory pain. Animal studies represent a valuable tool for studying the complexities of inflammation, which involves a concert of cell types. However, the interplay between changes at the cellular level and the …
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The Life History of Damaraland Mole-rats Fukomys damarensis: Growth, Ageing and Behaviour
The social mole-rats have often been typecast as extreme examples of mammalian sociality. With their pronounced reproductive skew, status-related contrasts in lifespan and morphology, and the suggestion of a division of labour amongst helpers, mole-rat societies have repeatedly been likened to the …
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Disease susceptibility and phenotypic adaptations as seen through the lens of comparative functional genomics
… model rodent clades: mice species and African mole-rats, this research offers insights into the molecular drivers of evolution and disease susceptibility across different evolutionary timescales. In the first part of the thesis, I present a project I worked on as part of the Liver Cancer …