Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Na channel"”.
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Mechanism of Inhibition of Transepithelial Sodium Transport in Frog Skin by Quinine and Quinidine (Noise Analysis, Cgs 4270, Basolateral Membrane)
… the electrophysiological characteristics of the Na('+) transporting epithelial cells of frog skin. Under control conditions with tissues bathed symmetrically with a Cl-HCO(,3) Ringer solution and short-circuited continuously, quinine caused a rapid inhibition of the I(,sc) while quinidine caused …
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The sophisticated architecture of the rat atrioventricular node
… and ventricles. Since Tawara described the anatomical and morphological characteristics of the AV node in 1906, it has been difficult to correlate electrophysiological recordings with distinct cell types and the three dimensional structure of the AV node due to the exceptional functional and …
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Effektivität von positiv inotropen Substanzen am Vorhofsmyokard von Patienten mit chronischem Vorhofflimmern
… positiv inotropic intervention. Hence we analysed the effect of some positive inotropic agents on the atrial myocardium of patients with chronic atrial fibrillation in vitro. Methods: Biopsies of the right human auricle of the human heart were taken from patients undergoing open mitral …
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Quantification of gene expression in single cells
… in individual cells with real-time RT-PCR. mRNA for hormones, ion channels and enzymes in pancreatic alpha- and beta-cells were quantified. The distribution of transcript levels were highly skewed and was best described by a lognormal distribution. Thus, the geometric--and not the commonly …
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Voltage-Gated Sodium Channel Activity in Mouse Skeletal Muscle Fibers: Normal Gating and Defects Associated with Periodic Paralysis Mutants
… in SCN4A, the gene encoding the skeletal muscle Na+ channel (NaV1.4) α-subunit, cause several disorders related to skeletal muscle excitability. The functional consequences of these NaV1.4 mutations have been extensively characterized in heterologous expression systems. These studies have …
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WNK Family Kinases and the Regulation of Ion Flux
… or WNK family of serine/threonine protein kinases have an unusual arrangement of their catalytic lysines. WNK1 and WNK4 have been genetically linked to a rare type of hypertension. Studies demonstrate that these kinases regulate the activity of a diverse group of proteins that in toto suggest …
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Possible role of the ventromedial hypothalamus in estrus termination following vaginocervical stimulation of the rat
… which VCS accelerates the onset of estrus termination in rats are not completely understood yet. Hence, the present study investigated the role of the ventromedial hypothalamus (VMH) in estrus termination using sexually experienced ovariectomized female rats. First, females were administered …
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A Putative Cytosolic Saxitoxin Binding Protein in Frog Myocardium
… from the hearts of the North American frog Rana pipiens pipiens is solubilized by a 96 hour dialysis of the vesicles against a low ionic strength solution of ethylene-diaminetetraacetic acid (EDTA) at pH 8.5. All of the polypeptides of the vesicle proteins which are resolvable by sodium …
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MES-DERIVED CARDIOMYOCYTES AS CELLULAR MODEL TO STUDY CARDIAC DISEASES: ALTERATIONS IN STRN AND GNB5 GENES
… lines. 10-12-day old beating mESC-CMs were analyzed by Patch-clamp, motion video tracking, Ca2+ dynamics and immunofluorescence analysis. STRN-KO cells have a higher spontaneous beating rate and faster action potential depolarization (dV/dt) than WT, correlated with a larger fast INa …
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Analysis of ion channels with hidden Markov models : parameter identifiability and the problem of time interval omission
… with a certain class of stochastic processes, namely the hidden Markov models. Hidden Markov models have proved to be an appropriate description for the ionic current through specialised proteins situated in the cell membrane. These ion channels open and close randomly and control the flux of …
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Keeping Pace with Interstitial Cells of Cajal: Modelling Gastrointestinal Electrophysiology
Gastrointestinal (GI) motility is coordinated by several cooperating mechanisms, including myogenic, neural and hormonal control systems. This thesis focuses on one of these mechanisms: an intrinsic bioelectrical activity called slow waves, which originates in pacemaker cells called interstitial …
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An Intramural, Tension-modulating Reflex in the Rat Caudal Artery
… relaxation. This relaxation is of either neuronal, vascular smooth muscle, and/or endothelial origins. We have shown that EFS-induced relaxation of intact, phenylephrine (PE) preconstricted rat tail artery (RTA) rings was dependent upon the extracellular concentration of Ca++. Inhibiting either …
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The signalling pathways allowing hormonal regulation of Na+ transport in murine collecting duct cells
… duct of the distal nephron marks the final location where adjustments to Na+ excretion can be made, therefore determining the final concentration of Na+ conserved in the extracellular fluid which plays a role in governing overall blood volume and pressure. This transport of Na+ is …
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Effects of Ca2+, microRNAs, and rosuvastatin on insulin-secreting beta cell function
… thesis I have investigated the role of Ca2+, miRNAs and rosuvastatin in the regulation of ion channels, exocytosis and insulin secretion of beta cells. For this purpose, pancreatic rat INS-1 832/13 beta cells, rodent animal models, and islets from human cadaver donors has been used. Whole-cell …
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Magnesium homeostasis in the mammalian heart
… of extracellular Mg2+ on contractility and coronary flow and the effects of hormonal and extracellular cationic control of Mg2+ homeostasis in the rat heart. Subsequently, the effects of dietary magnesium on the magnesium, calcium, sodium and potassium content of the heart (and other tissues) in …
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Hormone-induced expression of the epithelial sodium channel in human airway cells
Respiratory distress syndrome and pulmonary oedema often result in poor health and in the worst case scenario, death. Several studies have proposed that the eventual resolution of these dangerous conditions is due to active sodium reabsorption through the epithelial sodium channel (ENaC), which is …