Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Na/H exchanger"”.
-
Characterization of Na+/H+Exchanger-3 (Nhe3) in the Gills of Longhorn Sculpin (Myoxocephalus Octodecemspinosus)
… to maintain optimal acid-base balance. The Na+/H+ Exchanger-3 (NHE-3) has been shown to be the primary membrane ion transporter responsible for acid-base balance in the mammalian kidney. The objective of this study is to characterize NHE-3 in the gills of longhorn sculpin (Myoxocephalus …
-
Sodium entry pathways in isolated goldfish hair cells
… ionic environment. This study explored Na-coupled ion transport processes in isolated goldfish hair cells both in the steady state and in response to perturbations. Intracellular Na⁺ concentration ([Na⁺]i) and pH (pHi) were measured using the fluorescent probes SBFI and BCECF, …
-
Biological studies of organellar (Na⁺,K⁺)/H⁺ exchanger NHE7
… functions, and it is now widely recognized that Na⁺/H⁺ exchangers are among the most prominent players in this process. Although recently described mammalian Na⁺/H⁺ exchanger NHE7 has attracted much attention, its biological functions remain largely unknown. Most proteins exist as protein …
-
The development of motility in spermatozoa
… spermatozoa shows that pH, cAMP and protein kinase C (PKC) all play an important role in the initiation of motility. pH has the most critical role and until the initial pH change in spermatozoa has occurred between the caput and caudal epididymal regions of the rat, second messengers are not …
-
ROLE OF ACID SPHINGOMYELINASE IN ICAM-1/NHE1-DEPENDENT ENDOCYTOSIS: IMPLICATIONS IN LEUKOCYTE TRANSMIGRATION
… clathrin-/caveolae-independent pathway involving Na+/H+ exchanger 1 (NHE1). ICAM-1 itself plays a key role in transendothelial migration (TEM) of leukocytes, particularly via the transcellular route. This involves endothelial endocytic vesicles that coalesce into transmigration pores, through …
-
Macromolecular Complexes of Cystic Fibrosis Transmembrane Conductance Regulator Alter Fluid Transport in inflammatory Bowel Disorders
… function. We report the physical and functional coupling of CFTR with nitric oxide (NO) producing enzyme-inducible nitric oxide synthase (iNOS) at the apical plasma membrane in inflammatory bowel disease (IBD). The complex formation requires the scaffolding protein Na+ /H+ exchanger …
-
Developing C. elegans as a model to study Type 2 Diabetes Mellitus
… the mitochondrial activity through endosomal Na+/H+ exchanger, which a previous lab member has found to be a potential target of metformin. Furthermore, we show that high glucose diet−known to reduce the worm’s lifespan−alter the endosomal-lysosomal system and autophagy, providing insights to …
-
Nherf1 – New Modifier of Colorectal Cancer Progression
… progressive modifications of normal intestinal epithelium into adenocarcinoma. Loss of cell polarity has been implicated as an early event in this process, but the molecular players involved are not well known. NHERF1 (Na+/H+ Exchanger Regulatory Factor 1) is an adaptor protein with apical …
-
The functional motifs for nucleocytoplasmic shuttling of C-terminal fragment of c-Met : A novel "pH-dependent' nuclear localization signal
The C-terminal fragment of the c-Met receptor tyrosine kinase is present in the nuclei of various cells irrespective of ligand stimulation, but neither the specific amino acid motif nor the responsible nuclear localization signal (NLS) has not been previously reported. Here, we report that two …
-
Estrogen Receptors and Estrogen-Regulated Genes in the Male Reproductive Tract
… the most important epithelial ion transporters, Na+/H+ exchanger-3 (NHE3), and then influences the passive transepithelial water movement in efferent ductules. In addition to its regulation of Na + transport, estrogen also maintains epithelial morphological differentiation in efferent ductules of …
-
Mechanisms of Exercise-Mediated Restoration of Renal Dopamine D1 Receptor Function in Aging
Renal dopamine plays a pivotal role in the maintenance of sodium homeostasis and blood pressure. Dopamine by activating D1 receptors (D1R) and inhibiting sodium transporters, Na, K-ATPase and Na, H exchanger, in renal proximal tubules (RPTs) promotes sodium excretion and thus maintains sodium …
-
Transgene Mausmodelle zur Charakterisierung der Funktion kardialer beta-adrenerger Rezeptoren
… beta-adrenerger Rezeptoren mit Hilfe einer Kombination aus transgenen Mausmodellen und physiologischen und molekularbiologischen Methoden untersucht. Durch gezielte Überexpression des humanen beta1-adrenergen Rezeptors im Herzen transgener Mäuse konnte gezeigt werden, daß die chronische …