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Showing 1 to 20 of 85 for “"Na+/K+-ATPase"”.
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Autoradiografische lokalisatie van Na+-K+-ATPase met 3H-ouabaine
Contains fulltext : mmubn000001_168227177.pdf (Publisher’s version ) (Open Access)
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Na,K ATPase, some aspects of structure and mechanism
Contains fulltext : mmubn000001_026999137.pdf (Publisher’s version ) (Open Access)
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ROLE OF THE Na,K-ATPase IN POLYCYSTIC KIDNEY DISEASE
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic disease, and is characterized by multiple fluid-filled cysts that impair the organ, ultimately leading to renal failure. Formation and enlargement of the cysts require abnormal proliferation and cell death, as well as …
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Cloning and Sequencing of Bovine Na+/K= Atpase α-1 Sub-Unit
… was cloning and sequencing the α-1 sub-unit of Na+/K+-ATase gene in bovine corneal endothelium. The Na+/K+-ATase, also called the Na+ pump, is a crucial transmembrane protein. By transporting water and ions from and through the cornea into the aqueous humor, it is responsible for maintenance of …
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Na,K-ATPase signaling in cyst progression in autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenetic disorder of the kidney, affecting 1:500-1000 live births across the world. It is characterized by the formation and growth of fluid-filled cysts which grow larger throughout the lifetime of the patient, eventually …
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Charakterisierung Migräne-relevanter Mutationen anhand Struktur-Funktions-Untersuchungen der Na+/K+-ATPase α2-Untereinheit
… Untereinheiten (α-, β-, γ-) aufgebaute Na+/K+-ATPase ist ein ubiquitäres Membranprotein, das zu den P-Typ-ATPasen gehört und maßgeblich an der Bildung und Erhaltung des Transmembranpotentials beteiligt ist. Als omnipräsente Ionenpumpe transportiert sie unter Verbrauch eines ATP-Moleküls …
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Factors influencing skeletal muscle Na+, K+-ATPase and Plasma [K+] during exercise in humans
… adenosine triphosphatase enzyme (Na+,K+ -ATPase) regulates muscle cell [Na+],[K+] and muscle membrane potential, therefore playing a fundamental role in muscle excitability. This dissertation primarily examined the effects of acute exercise, training status and chronic inactivity …
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Struktur-Funktionsbeziehungen der Na+/K+-ATPase anhand elektrophysiologischer Untersuchungen C-terminaler und Migräne-assoziierter Mutationen
Die Na+/K+-ATPase ist ein Transmembranprotein, das die Gradienten für Na+ und K+ über der Zellmembran aufrecht erhält, indem sie drei Na+-Ionen ins Extrazelluläre und zwei K+-Ionen ins Intrazelluläre unter Verbrauch von ATP transportiert, was von elementarer Bedeutung für die Zellfunktion ist. Eine …
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The effects of prolonged exercise on Na+, K+ - ATPase and SR Ca2+ regulation in humans
… but little is known about effects on muscle Na+, K+ATPase activity and sarcoplasmic reticulum (SR) Ca2+ regulation. We therefore investigated whether these processes were impaired during cycling exercise at 74.3±1.2% v02 peak (mean±SEM) continued until fatigue, in eight healthy subjects (v02 …
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Na+, K+-ATPase in single skeletal muscle fibres and the effects of ageing, training and inactivity
The Na+,K+-ATPase (NKA) is a key protein involved in the maintenance of skeletal muscle excitability and comprises 2 subunits (α and β), each of which express multiple isoforms at a protein level in skeletal muscle (α1-3 and β1-3). The fibre-specific expression, adaptability and roles of each …
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Digoxin and exercise effects on Na+,K+-ATPase isoform gene and protein expression in human skeletal muscle
… that exercise in humans impairs skeletal muscle Na+,K+-ATPase maximal in vitro activity, whilst in isolated rat muscles, Na+,K+-ATPase inhibition with ouabain leads to early muscle fatigue. Hence, Na+,K+-ATPase function is likely to be important for skeletal muscle performance. Digoxin is a …
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NKAINs: A Novel Family of Membrane Proteins that Interact with the Na, K-ATPase and Affect Membrane Excitability
<p>A novel family of Na,K-ATPase interacting (NKAIN) proteins was cloned and characterized. These proteins are highly conserved across species and do not resemble any known proteins in the genome. Aside from the conserved transmembrane domains, NKAINs contain no known functional domains. Striking …
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Exercise, electrical stimulation and ionic effects on Na+, K+-ATPase isoform gene and protein expression in mammalian skeletal muscle
… stimulation and explores factors regulating Na+,K+ -ATPase isoform transcription and translation in skeletal muscle.
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Efeito in vivo e in vitro da prolina sobre a atividade da Na+, K+-ATPase de cérebro de ratos
A hiperprolinemia tipo II é um erro inato do metabolismo de aminoácido causado pela deficiência na atividade da Ä1 pirrolino-5-carboxilato desidrogenase. O bloqueio dessa reação resulta no acúmulo tecidual de prolina. A doença caracteriza-se fundamentalmente por epilepsia, convulsões e um grau …
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The effects of osteoarthritis, acute voluntary inactivity and injury on skeletal muscle function, Na+, K+ -ATPase content and isoform abundance
Physical inactivity causes substantial maladaptions in each of skeletal muscle size, strength and endurance. In skeletal muscle the Na+, K+ -ATPase (NKA) enzyme is pivotal in the regulation of Na+ and K+ concentrations across the sarcolemmal and t-tubule membranes and hence in the maintenance of …
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Physiological Role of the α<sub>2</sub>-Isoform of the Na, K-ATPase in the Regulation of Cardiovascular Function
<p>Na,K-ATPase is a ubiquitously expressed heteromeric transmembrane protein composed of two essential subunits: α and β. There are four known isoforms of the catalytic α-subunit (α<sub>1</sub>, α<sub>2</sub>, α<sub>3</sub>, and α<sub>4</sub>), and each isoform displays a unique tissue distribution …
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The Na/K-ATPase in the gills of Antarctic and New Zealand nototheniids: The Physiologic and Molecular Effects of Warm-acclimation.
… increase in serum osmolality is due to proportional increases in the Na" and CT concentrations as compared to temperate teleosts, including members of the same family. The sodium and potassium adensosine triphosphatase (Na/K-ATPase) in the chloride cells of the gill is responsible for maintenance …
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Effects of exercise, renal disease, and digoxin on skeletal muscle Na+,K+-ATPase and related effects on plasma K+ and muscle performance
In skeletal muscle, the Na+,K+-ATPase enzyme regulates trans-membrane Na+ and K+ fluxes during contractions, and therefore also affects muscle excitability and plays an important role in delaying muscle fatigue. Consequently, any modulation of Na+,K+-ATPase content or activity has the potential to …
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Effects of Chronic Intermittent Hypoxia, Acute and Chronic Exercise on Skeletal Muscle Na+,K+ATPase, Buffering Capacity and Plasma Electrolytes in Well-Trained Athletes
… acute and chronic exercise on skeletal muscle Na+,K+ATPase, buffering capacity and plasma electrolytes. Thus the effects of acute exercise and these interventions in well-trained athletes are the focus of this thesis.
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Regulation of Intracellular pH and Plasma Membrane Potential in Trypanosoma Cruzi and Trypanosoma Brucei
… was found to be regulated primarily by a H+-ATPase with support from a Cl- conductive channel in all stages and an inwardly directed K+ channel in the mammalian stages. The DeltaPsi in T. cruzi was found to be generated by a H+-ATPase in all stages however there were significant differences …
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