Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Na+/K+ Pump"”.
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Differential Na+/K+ Pump Isoform Expression in Higher and Lower Brain Regions of the Mouse
… resilient. Discovering how lower brain neurons naturally resist ischemic stress may help to design new strategies for improving higher brain survival following ischemia. Our laboratory has proposed that differential expression of Na+/K+-ATPase isoforms, the ion pumps responsible for maintaining …
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A modeling study of the history-dependence of conduction delay in unmyelinated axons
… properties, voltage-gated ion channels and the Na+/K+ pump, and can be substantially affected by neuromodulators. The conduction delay of action potential, generated by the pyloric dilator (PD) neuron unmyel i nated motor axon in the stomatogastric nervous system, shows significant variability …
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Molecular Mechanisms of Physalia Physalis Venom Modulation of Cardiac and Vascular Functions
… mechanism for the embryonic chick heart to eliminate excessive cytoplasmic free calcium. Rubidium (an analog of potassium) influx is not affected by <em>P. physalis </em>venom at lower dose levels. A high concentration of the venom, nevertheless, decreases rubidium influx, implicating an …
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Tissue injury and remodeling in rat hippocampal dentate gyrus following sodium-potassium-ATPase inhibition.
Na+, K+-ATPase is a ubiquitous membrane enzyme that plays an important role in maintaining neuronal excitability, ionic homeostasis and cell survival. Although failure of the Na+, K+-ATPase pump has been implicated in the pathophysiology of a variety of neurological conditions, the timeline and …
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The development of motility in spermatozoa
… spermatozoa shows that pH, cAMP and protein kinase C (PKC) all play an important role in the initiation of motility. pH has the most critical role and until the initial pH change in spermatozoa has occurred between the caput and caudal epididymal regions of the rat, second messengers are not …
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Higher Brain Neurons Succumb to Acute Stroke-Like Insult While Lower Brain Neurons Strongly Resist
… neurons generate strong AD and show no functional recovery in contrast to neurons in hypothalamus and brainstem that generate a weak and gradual AD. Most dramatically, lower neurons recover their membrane potential, input resistance and spike amplitude when oxygen and glucose is restored, while …
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Mathematical modelling of energy demand and supply in the cardiac myocyte
… endoplasmic reticulum Ca²⁺ ATPase (SERCA) pump and the acto-myosin cross-bridge cycle which, along with the Na+/K+ pump, are the key energy-consuming processes in the cardiomyocyte. These models encapsulate both thermodynamic considerations and metabolite sensitivity into a cycle-based …
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A Computational Model of the Ocular Lens
The aim of this project is to develop a computational model of the structure and function of the ocular lens, specifically the solute and fluid transport in the lens. The modelling framework was based on finite volume methods. The intracellular and extracellular solute fluxes were modelled using …
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Digoxin and exercise effects on Na+,K+-ATPase isoform gene and protein expression in human skeletal muscle
… that exercise in humans impairs skeletal muscle Na+,K+-ATPase maximal in vitro activity, whilst in isolated rat muscles, Na+,K+-ATPase inhibition with ouabain leads to early muscle fatigue. Hence, Na+,K+-ATPase function is likely to be important for skeletal muscle performance. Digoxin is a …