Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Na+/H+ exchange"”.
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The Role of Dysfunctional Na+/H+ Exchange in the Development of Dysbiosis and Subsequent Colitis
… of autoimmune disease in industrialized nations too rapid to be accounted for by genetics alone. Among those, Inflammatory Bowel Disease (IBD) has risen from a western disease affecting industrialized populations to an emerging global threat affecting diverse populations around the world. …
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The pharmacological modification of reperfusion injury with particular reference to calcium fluxes in the isolated rat heart
… was measured by reperfusion aortic output, coronary flow and left ventricular pressure. The incidence of reperfusion ventricular arrhythmias was measured by the incidence of ventricular tachycardia and/ or fibrillation. In selected studies, the metabolic status of hearts was evaluated using …
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Cxcr2 Macromolecular Complex In Pancreatic Cancer: A Potential Therapeutic Target In Tumor Growth
<p>The signaling mediated by the chemokine receptor CXC chemokine receptor 2 (CXCR2) plays an important role in promoting the progression of many cancers, including pancreatic cancer, one of the most lethal human malignancies. CXCR2 possesses a consensus PSD-95/DlgA/ZO-1 (PDZ) motif at its carboxyl …
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Dilution acidosis : the effects of hyperosmolality on acid-base balance and ventilation
… control were studied in the Pekin duck, Anas platyrhynchos. Acute hyperosmolality following intravascular injection of essentially non-penetrating solutes such as NaCl or sucrose caused an increase in extracellular fluid volume, a prolonged extracellular acidosis (so-called dilution …
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Distal tubule bicarbonate reabsorption.
… certain aspects of the control of bicarbonate reabsorption in the surface distal tubule of rats made acidotic by ammonium chloride treatment. During acute metabolic acidosis, the effects of sodium delivery, water reabsorption, inhibition of carbonic anhydrase, and addition of the anion …
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Molecular mechanisms of TOM1-mediated protein trafficking in health and disease
TOM1 is an adaptor protein involved in the alternative ESCRT-0 pathway. TOM1 functions by recognizing the ubiquitin moieties on internalized receptors and sorting them towards the degradative arm of the lysosomal system. Two mechanisms of TOM1 aberrant function were uncovered: one mechanism due to …
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Observing molecular interactions that determine stability, folding, and functional states of single Na+/H+ antiporters
… process occurring in all types of cells. Evolutionarily developed transport proteins work as membrane-embedded molecular machines, which alternately open a gate on each side of the membrane to bind and translocate specific ions. Sodium/proton exchange plays a crucial role in maintaining …
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Pharmacological activation of pro-survival pathways as a strategy for improving donor heart preservation
… by the activation of endogenous pro-survival signalling pathways by the addition of pharmacological agents to Celsior, a clinical preservation solution. Studies were conducted in an isolated working rat heart model of donor heart preservation. The first study investigated the cardioprotective …