Global ETD Search
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Showing 1 to 8 of 8 for “"Na+/Ca2+ Exchanger"”.
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MES-DERIVED CARDIOMYOCYTES AS CELLULAR MODEL TO STUDY CARDIAC DISEASES: ALTERATIONS IN STRN AND GNB5 GENES
… lines. 10-12-day old beating mESC-CMs were analyzed by Patch-clamp, motion video tracking, Ca2+ dynamics and immunofluorescence analysis. STRN-KO cells have a higher spontaneous beating rate and faster action potential depolarization (dV/dt) than WT, correlated with a larger fast INa …
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Spatial organization of sodium calcium exchanger and caveolin-3 in developing mammalian ventricular cardiomyocytes
… calcium release (CICR) mediated by L-type Ca2+ channels (Cav1.2). Briefly, membrane depolarization opens voltage-gated Cav1.2 to allow for the influx of extracellular Ca2+ into the cytosol. This small sarcolemmal (SL) Ca2+ influx is necessary for triggering a larger release of Ca2+ from the …
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The role of intracellular Ca2+ in the arrhythmogenic activity of pulmonary vein cardiomyocytes
The pulmonary veins are widely recognised as a source of ectopic electrical activity that can cause atrial fibrillation. While the ectopic activity likely originates in the cardiomyocytes that form an external sleeve around the veins, the underlying mechanisms are unknown. Changes in intracellular …
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Role of transient receptor potential channels in mammalian oviduct and uterine epithelia
… potential (TRP) channel superfamily and the Na+/Ca2+ exchanger. TRP channels are an important class of calcium channels with more than 28 identified members and their potential involvement in calcium transport in uterus and oviduct epithelia has yet to be determined. The aim of this study was …
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Myocardial force and intracellular Ca2+ in an animal model of hypertensive heart failure
… the relationship between intracellular calcium ([Ca2+]i) and isometric force during the relatively narrow time frame in which long-standing compensated hypertrophy progresses to decompensated end-stage heart failure in an animal model of human essential hypertension. In order to carry out this …
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PHARMACOLOGICAL MODULATION OF SARCOPLASMIC RETICULUM CALCIUM ATPASE AND CALCIUM RELEASE CHANNELS FOR MUSCLE CELL PROTECTIVE ACTION
Abnormal homeostasis of intracellular Ca2+ plays a deleterious role in muscle pathologies by triggering processes that lead to dysfunction and necrotic or apoptotic cell death. One pathology where there is significant Ca2+ induced cell damage is ischemia, which initiates further damage (also …
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Regulation des Na+/Ca2+-Austauschers in kultivierten Podozyten der Maus
Der Na+/Ca2+-Austauscher ist an der zellulären Ca2+-Homöostase beteiligt. Er arbeitet in zweierlei Modi: dem Forward Mode und dem Reverse Mode. Letzterer dient dem Ca2+-Export nach einem transienten Anstieg der intrazellulären Ca2+-Konzentration, sei es im Rahmen physiologischer Vorgänge …
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Cellular mechanism of contractile dysfunction in the diabetic heart
… relevant concentration of the volatile anaesthetic halothane (0.6 mM) was used examine its effect on contractile properties of STZ-induced diabetic heart. Diabetes was induced in male Wistar rats by a single i.p. injection of STZ (60 mg Kg-1, body weight) which, resulted in an …