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Showing 1 to 12 of 12 for “"NZO"”.
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Identifikation und Charakterisierung von Suszeptibilitätsloci für Adipositas und Hypercholesterinämie in der NZO-Maus
… of the obese, hyperglycemic New Zealand obese (NZO) mouse with the lean SJL strain was established in order to locate genes responsible for obesity and the associated syndrome of insulin resistance, hyperglycemia and dyslipidemia, and to compare the effects under a standard and a high fat diet. …
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Identifizierung und Charakterisierung von Suszeptibilitätsloci für Typ-2-Diabetes mellitus in einem Mausmodell für das Metabolische Syndrom
New Zealand Obese (NZO) mice exhibit a polygenic syndrome of morbid obesity, insulin resistance, and arterial hypertension that resembles the human metabolic syndrome. In addition, adult NZO-males are severely hyperglycemic and hypoinsulinemic. In order to localize the genes responsible for this …
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School traditional leadership partnership in Alfred Nzo East Education District: a case study of three secondary schools notorious for school violence
… This was a qualitative case study of the Alfred Nzo East Education District, which made use of a case research design. Data was collected using semi-structured interviews and document analysis. Data analysis adopted theoretical prepositions and a thematic analysis approach. This study revealed …
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Microarray-basierte Expressionsanalysen des weißen Fettgewebes der NZO-Maus sowie der Langerhansschen Inseln der NZL-Maus : zwei Modelle für das metabolische Syndrom
… Zweck wurden Diät-Interventionsstudien mit NZO- und verwandten NZL-Mäusen, zwei polygenen Mausmodellen für das humane metabolische Syndrom, durchgeführt. Eine kohlenhydrathaltige Hochfett-Diät (HF: 14,6 % Fettanteil) führte in beiden Mausmodellen zu früher Adipositas, Insulinresistenz und …
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Einfluss von Glucolipotoxizität auf die Funktion der β-Zellen diabetessuszeptibler und –resistenter Mausstämme
… sowie diabetessuszeptiblen (New Zealand Obese, NZO) Mausmodell zu untersuchen. Es sollten molekulare Mechanismen identifiziert werden, die zum Untergang der β-Zellen in der NZO-Maus führen bzw. zum Schutz der β-Zellen der ob/ob-Maus beitragen. Zunächst wurde durch ein geeignetes diätetisches …
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Positionelle Klonierung von Tbc1d1 als Kandidatengen für Adipositas
… in einem Rückkreuzungsexperiment der Mausstämme NZO (adipös) und SJL (schlank) identifiziert wurde. Um Kandidatengene für Adipositas zu finden, wurden mehr als 300 Nob1-Transkripte mit Hilfe von Genexpressionsanalysen auf Unterschiede in stoffwechselrelevanten Geweben zwischen beiden Mausstämmen …
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Shifting economic perceptions in South Africa: the impact of migration
… a particular migration pathway between "Alfred Nzo" - a district municipality in the rural northeast of the Eastern Cape centered on the town of Mount Frere - and Cape Town. Twenty-six individuals were interviewed, from three different, and socially and economically relevant, migration …
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Differentielle hepatische Genexpression in einem Mausmodell mit polygener Adipositas, Insulinresistenz und Hyperglykämie
New Zealand Obese (NZO) mice exhibit a polygenic syndrome of morbid obesity and insulin resistance, that resembles the human metabolic syndrome. In order to define its biochemical basis, the differential expression of genes involved in hepatic glucose and lipid metabolism was studied. An outcross …
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Understanding the role of public preferential procurement on the development of black owned construction SMME'S IN South Africa
The research explored the long-term relationship between FDI, GDP and host country employment by using sector-wise panel data from 1991 to 2017 in Namibia. The study applied unit root testing and Cointegration test to test for the presence of a cointegration relationship between the variables. …
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Towards a framework for assessing the impact of organisational capacity on integrated transport planning in district municipalities
… need. Drawing on two case studies (the Alfred Nzo and Sedibeng District Municipalities), the study set out to assess how adequately District Municipalities (DMs) meet the minimum requirements for the preparation of ITPs. The study also set out to assess organisational capacity constraints that …
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Insights into the piRNA pathway through 16 strains of mice
… strains (C57BL/6NJ, BALB/cJ, A/J, DBA/2J, AKR/J, NZO/HlLtJ, NOD/ShiLtJ) where these transposable elements (TE) are found. Conversely, strains lacking this TE insertion do not show similar expression patterns. In sum, this work offers new perspectives on piRNA dynamics and their influence on germ …
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Chemistry and properties of perhydrobenzo[4.5.6]cholestanes
… approach to the synthesis ofperhydrobe,nzo[4.5.6]cholestanes. A reaction sequence has been developed to obtain the 3 P-acetoxy-4cx.,5cx. - dihydrobenzo [ 4.5 .6] cholestan-5' (6'H)-one 85 in an optimised yield from the 3Pacetoacetoxy-i:4-6-ketone 71. The key steps in the transformation …