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Showing 1 to 5 of 5 for “"NUDIX"”.
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Role of Nudix-Hydrolase ASMTL in Modulating Mitochondrial Biogenesis of Cancer Cells
Cancer cells have enhanced DNA biosynthesis, rendering them susceptible to nucleotide modifications that enter the cellular nucleotide pool during repair or DNA degradation. These modified nucleotides can then be incorporated into newly synthesized DNA, resulting in random mutations or, when …
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Role of Nudt21 Mediated Alternative Polyadenylation and Hyaluronan In The Development of Pulmonary Hypertension
… polyadenylation (APA) due to depletion of Nudix Hydrolase 21(NUDT21) is involved in several disease states including the chronic lung disease idiopathic pulmonary fibrosis (IPF). Additionally, hyaluronan, an extracellular matrix glycosaminoglycan has been associated with PH. The role and …
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Alternative Polyadenylation Modulates Expression of Pro-Fibrotic Proteins and Contributes to Lung Fibrosis
… Our laboratory and collaborators have shown that nudix hydrolase 21 (NUDT21, which is also known as cleavage factor 25, CFIm25) is a key regulator of alternative polyadenylation (APA). NUDT21 depletion causes 3’UTR shortening via APA leading to enhanced mRNA stability and protein translation. This …
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Inositol Pyrophosphate Phosphatases as Key Enzymes to Understand and Manipulate Phosphate Sensing in Plants
Phosphorus (P) is one of the three major macronutrients that plants need to grow and survive. When P is scarce, plants utilize a network of characterized responses known as the Phosphate Starvation Response (PSR) to remobilize internal stores of P as well as external P from soil. Emerging evidence …
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Mechanisms of polyphosphate degradation
The goal of my research has been to investigate the mechanisms by which inorganic polyphosphate (polyP) is degraded in vivo. PolyP is a linear chain of phosphate moieties linked through high-energy phosphoanhydride bonds and can range in size from three-phosphates-long to thousands. Naturally, …