Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"NTR"”.
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Use of a direct, positive selection strategy to generate improved prodrug-activating enzymes for cancer gene therapy
E. coli NfsB nitroreductase (NTR) is currently being studied in combination with the prodrug CB1954, as a gene directed enzyme prodrug therapy. NTR reduces CB1954 at either the 2- or 4-nitro groups to produce highly cytotoxic hydroxylamine derivatives, using either NADH or NADPH as cofactor. …
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The synthesis and study of novel fluorescence probes for Nitroreductase
… and study of novel fluorescence probes for NTR’ is divided in 7 chapters. Chapter 1, provides an introduction to cancer, reductive stress and some techniques to detect the tumour cells. A range of relevant examples of fluorescence sensors for NTR are also given. This Chapter also includes …
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Role of N-Terminal Region in Modulating RNA Binding Activity of the La Module in Vertebrate LARP6
… studies have shown that the N-terminal region (NTR) of LARP6 appears to play a role in RNA binding activity and specificity, as well as being suspected of interacting with the La Module domain. To further explore the effect of the NTR on the overall RNA-binding function of the protein, we …
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A Computational Investigation of the Mechanism of CB1954 Reduction by E.coli Nitroreductase
The flavoenzyme NTR (nitroreductase nfsB from Escherichia coli) and the prodrug CB1954 (5-[aziridin-1-yl]-2,4-dinitrobenzamide) have been found to be a good potential combination for virus-directed enzyme prodrug therapy (VDEPT). However, wild-type NTR has poor kinetics and binding with CB1954, and …
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Targeted gene therapy for canine osteosarcoma: preliminary investigations
… gene/prodrug assays using nitroreductase (NTR) in combination with CB1954 or nitrofurazone (NFZ) in several canine cell lines; replace luciferase with NTR in vectors for TP53-targeted suicide gene strategy, and with CB1954, determine if survival of CMT7 cells possessing accumulated TP53 …
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Characterization of the thioredoxin system in Methanosarcina mazei
… are known, namely NADPH thioredoxin reductase (NTR) with NADPH as the electron donor and ferredoxin thioredxoin reductase (FTR) which depends on reduced ferredoxin as electron donor. Although NTR is widely distributed in the three domains of life, it is absent in some archaea, whereas FTRs are …
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Single molecule investigation of transcription activator-like effector search dynamics
… for precise and targeted genomic edits are central to the rising popularity, flexibility, and accessibility of gene engineering. Transcription activator-like effectors (TALEs) are one such class that form a powerful gene-editing platform when fused to nuclease domains, thereby yielding TALEN …
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Development of tumour imaging and therapy strategies utilising unengineered bacteria
… presence of these enzymes. Exploitation of the intrinsic enzymatic activity of bacteria allows the use of a wider range of bacteria and presents a more clinically relevant system than those that are currently in use. The nitroreductase (NTR) enzymes, found only in bacteria, represent one such …
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Essays on International Trade
… the grant of permanent normal trade relations (PNTR) status to China by the U.S. Congress in 2000 to the evolution of manufacturing employment in China from 1998 to 2007. Generalized difference-in-differences estimates show that Chinese manufacturing industries with high-NTR gaps experience …
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Interactions of Thyroid Hormones, Nerve Growth Factor and Its Receptors in Development and Plasticity of the Rat Olfactory Bulb
… while up-regulating NGF receptors, p75$\sp{\rm NTR}$ and trkA in the glomerular region. We propose that decreased bulbar NGF results in decreased trophic support for specific NGF responsive cells, leading to compensatory up-regulation of NGF receptors which compete for the limited supply of NGF. …
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CHLAMY 1, ein circadianes RNS-Bindeprotein aus Chlamydomonas reinhardtii
… Expression von C3 (44 kDa) von der inneren Uhr kontrolliert zu sein scheint. Durch die Sichtung einer Expressions-Genbank aus C. reinhardtii mit Peptid- Antikörpern wurden zwei für CHLAMY 1 kodierende cDNS-Fragmente isoliert und durch EST-Klone aus dem Sequenzierungsprojekt von C. reinhardtii …
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Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer
… two oncolytic adenovirus vectors, CRAd-NTR and vNR6, both of which contained the E1B-55K deletion and expressed the transgene nitroreductase for combined oncolytic virotherapy and enzyme/prodrug gene therapy. The latter of these two vectors, vNR6, expressing nitroreductase from the pIX …
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Generalized multi-commodity network flows : case studies in space logistics and complex infrastructure systems
… the GMCNF model proposed in this thesis introduces three types of matrix multiplications (requirement, transformation, and concurrency), and also allows loop edges associated with nodes (graph loops) and multiple edges between the same end nodes (multigraph). With this modification, the …
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The Effects Of Oxidative Stress On P75ntr Signaling In Dopaminergic Neurons
<p>The p75 neurotrophin receptor (p75NTR) is responsible for implementing cellular death during embryonic development and in response to cellular injury. The receptor has been recognized as a contributor of neurodegeneration in numerous pathological conditions. Cleavage of p75NTR by Tumor Necrosis …
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Synthetic Materials with Redox-Triggers for Imaging and Drug Delivery
… at a simulated redox-state compared to the control. Cell viability studies revealed that the polymer was non-toxic and the nanoparticles and micelles could release paclitaxel to suppress breast cancer cell growth. In addition to the drug delivery system, a p-nitrobenzyl moiety redox trigger …
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Nitroaromatic pro-drug activation and resistance in the African trypanosome
… disease that affects some of the poorest countries in sub-Saharan Africa. Although the disease prevalence is declining, strengthening of the current control efforts, including introduction of more adequate chemotherapeutic options, is needed to prevent the re-emergence of yet another …
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Molecular Mechanisms in Primordial Germ Cell Development in Zebrafish
… Uridin-reicher Regionen innerhalb der 3 NTR der Target-mRNA. Da Dead end und Komponenten des microRNA Prozesses in den Keimgranulaten lokalisiert sind, wird deren Interaktion wahrscheinlich innerhalb dieser Strukturen ausgeführt.
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Post-Disaster Road Network Resilience Assessment
… any transportation simulation model. The main contribution of this research is, therefore, to develop, calibrate and validate a mesoscopic model of the South Island road network and develop a novel approach to assess the resilience of the network following a disaster. To assess the operational …
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Role of host chromatin remodelling in Mycobacterium leprae-induced Schwann cell fate change
… Mycobacterium leprae is a strictly obligate, intracellular bacterium that is a causative agent of the chronic infectious disease Leprosy. In humans, M. leprae infects Schwann cells, a type of glial cell that surrounds neurons and is responsible for the formation of the myelin sheath that …
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Resiliência e estabilidade produtiva de clones de batata-doce (Ipomoea batatas L.) como estratégia de adaptação às mudanças climáticas
… reduzindo a produtividade de diversos cultivos, entre eles a batata-doce, cuja disponibilidade de cultivares tolerantes ao déficit hídrico ainda é limitada. Dessa forma, o objetivo deste trabalho foi avaliar a tolerância de dez genótipos de batata-doce ao déficit hídrico. O ensaio experimental foi …
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