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Showing 1 to 16 of 16 for “"NTCP"”.
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Head and Neck Cancer Offline Adaptive Radiotherapy Proof-of-Concept Workflow for Low-Resource Clinics Utilizing NTCP
… normal tissue complication probability (NTCP) metrics. NTCP values were retrospectively calculated and compared between the planned dose and true delivered dose. Adaptive replanning was deemed warranted for a patient plan if the change in NTCP (∆NTCP) for an OAR was 5% or greater. …
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Differentielle Regulation organischer Anionentransporter der Oatp-Familie bei Ethinylöstradiol-induzierter Cholestase der Ratte
… the basolateral Natrium/bile acid cotransporter (Ntcp), whereas sodium-independent uptake is maintained despite a down-regulation of the organic anion transporter Oatp1. Thus, expression of the two other rat Oatps (Oatp2 and Oatp4) was determined in estrogen-induced cholestasis. In Addition, known …
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Beyond The Dvh - Spatial And Biological Radiotherapy Treatment Planning
… (TCP), Normal Tissue Complication Probability (NTCP), and Complication-free TCP (P+). TCP, NTCP and P+ are provided as a function of prescribed dose and multi-variable TCP, NTCP and P+ plots are provided to illustrate the dependence upon individual parameters used to calculate these …
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Fasten-induzierte Regulation hepatischer basolateraler Gallensäuretransporter in Ratten vermittelt über PGC-1[alpha]/HNF-4[alpha]
… bile acid transporters. In rats, mRNA of Ntcp, Oatp1, and Oatp2 were significantly increased after 48 h of fasting. Protein expression as determined by Western blot showed significant increases for all three transporters 72 h after the onset of fasting. Whereas binding activity of …
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Towards Offline Adaptive Therapy for Prostate Patients using Velocity
… volumes. Workflow-estimated dose-to-bladder and NTCP were compared to ground-truth calculations. The average ratio of day-of-treatment bladder volume compared to simulation was 82±17% for 6 of the 7 patients. For these patients, the fROI and rROI workflows tended to over-estimate bladder volume, …
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Accumulating delivered dose to the rectum to improve toxicity prediction in prostate radiotherapy
… Current normal tissue complication probability (NTCP) models are based on planned dose data and do not consider the effects of organ motion on true delivered dose. The VoxTox research programme has developed automated solutions for segmentation and dose calculation of the rectum for prostate …
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Cuantificación de las diferencias dosimétricas generadas por la selección del algoritmo de cálculo en un sistema de planeación de radioterapia
… probabilidad de complicaciones en tejido normal NTCP."
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Effects of Advanced Radiotherapy techniques on Normal Tissue Toxicity in Breast Cancer
… of normal tissue complication probability (NTCP) model for breast fibrosis to quantify the clinical benefits of IGRT. The benefits of IMRT were assessed using clinician-based assessment, serial photographs for overall cosmesis and patient-reported outcome measures (PROMs). The project also …
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Quality Assurance of Advanced Treatment Modalities Using Presage® Dosimeters
… in the normal tissue complication probability (NTCP). An optical CT scanner was tested for reproducibility and reliability and a standard operating procedure was created. The PRESAGE<sup>®</sup> dosimeters were extensively tested for dose stability over a range of time for remote dosimetry …
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Adaptive Radiation Therapy Of Prostate Cancer
… patients with three different margins. EUD and NTCP were calculated to evaluate reaction of rectum to radiation. Rectal EUD increased 5-7% in the real delivery of the plan with 10/5 mm margin for all five patients. As the margin was reduced, the percent difference increased to 5-14%. Margin …
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Radiation biophysical modeling of the FLASH effect: from mechanistic understanding towards clinical endpoint prediction
… Normal Tissue Complication Probability (NTCP) model and Tumor Control Probability (TCP) model for both Conv and UHDR irradiations. This study aims to extend the MS-GSM2 to clinically relevant biological endpoints, integrating the radiation biophysical model MS-GSM2 into the Relative …
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ESTABLISHING AN IN VITRO MODEL FOR CRISPR-CAS9 SCREENING OF INTERFERON EFFECTORS IN HBV INFECTION
… candidate cellular models and identified HepG2-NTCP cells cultured with 2.5% DMSO as optimal. This condition promotes hepatocyte-like differentiation and supports both robust HBV infection and strong response to IFN-α. In addition to infection and IFN sensitivity, effective screening requires a …
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Quantifying, Understanding and Predicting Differences Between Planned and Delivered Dose to Organs at Risk in Head & Neck Cancer Patients Undergoing Radical Radiotherapy to Promote Intelligently Targeted Adaptive Radiotherapy
… normal tissue complication probability (NTCP) modelling approaches. A sub-study of VoxTox recruited 18 patients who had MRI scans before RT fractions 1, 6, 16, and 26. Changes in salivary gland volumes and relative apparent diffusion coefficient (ADC) values were measured and related to …
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Investigation of Radiation Injury In The Esophagus From Definitive Chemoradiation Therapy Using Novel Imaging Biomarkers
… These results were then applied to NTCP toxicity modelling by using patient radiosensitivity cluster membership as a predictor variable. Models with the radiosensitive predictor outperformed models not including the cluster membership variable for prediction of grade 3 …
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Improving Dose-Response Correlations For Locally Advanced Nsclc Patients Treated With Imrt Or Pspt
… of the normal tissue complication probability (NTCP) using an established, clinically used model, which could qualify the patients for treatment planning re-evaluation. Lastly, we associated dose difference with accuracy difference by establishing and comparing voxel-level dose-IDC correlations …
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Untersuchungen zur Wechselwirkung von Gallensalz tragenden Liposomen mit Hepatozyten
… ist der Gallensalztransporter Ntcp in seiner aktiven Form maßgeblich beteiligt. <br>Lang zirkulierende GSL werden in vivo im Gegensatz zu entsprechenden langlebigen KOL in der Leber angereichert. In der Leber sind die GSL entlang der Sinusoide orientiert, lang zirkulierende GSL …