Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"NSs protein"”.
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OROPOUCHE VIRUS DISRUPTION OF HOST CELL FUNCTIONS: PYROPTOSIS INDUCTION AND TRANSCRIPTIONAL SUPPRESSION
… as well as the effects of the non-structural protein from the small (S) segment of OROV (OROV NSs protein) in virus-infected culture cells. Macrophages are critical in host defense, but their response to OROV infection remains poorly understood. IL-1β, a key pro-inflammatory cytokine, plays a …
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Characterization of Innate Immune Mechanisms Against RVFV and a Potential Target for Antivirals
… of a tripartite genome (L-, M- and S- segments). NSs, encoded in the S- segment promotes degradation of PKR and general transcription shutoff including IFN-β mRNA synthesis. Currently, no effective measures have been developed to prevent or treat RVFV disease and very little is understood about …
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Discovering LC3-interacting region (LIR) motifs in hemorrhagic fever viruses: Implications for host autophagy and viral replication.
… the present study. The RVFV nonstructural small (NSs) protein is the main virulence factor of RVFV and we discovered four novel LC3-interacting region (LIR) motifs within NSs (NSs1-4), indicating that NSs interacts with LC3, the host key autophagy protein. Autophagy is a cellular process that can …
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Characterisation of the immune modulatory effect of wild type Rift Valley fever virus strains
… wurde die IFN-β-antagonistische Funktion des NSs-Proteins von RVFV Isolaten unterschiedlicher Herkunft (Säugetiere, Menschen und Insekten) nach Klonierung und Sequenzierung des jeweiligen Nichtstruktur S-Segment (NSs) Gens untersucht. Die immunmodulatorische Funktion von NSs wurde dahingehend …