Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"NSCs"”.
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Adaptação transcultural da escala Needs of Sexual Counseling Scale – NSCS para brasileiros com insuficiência cardíaca
… a escala NEEDS OF SEXUAL COUSELING SCALE-NSCS para utilização em brasileiros com insuficiência cardíaca. Estudo metodológico, realizado em duas etapas distintas: tradução e adaptação transcultural; e validade de conteúdo. A primeira etapa foi composta por cinco subetapas: Tradução inicial, …
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ADULT HUMAN BRAIN MENINGES HOST NEURAL STEM/PRECURSOR CELLS THAT CAN BE IN VITRO EXPANDED AND SHOW MULTIPOTENT NEURAL DIFFERENTIATION POTENTIAL IN 2D AND 3D CULTURE
… and proliferating neural stem/progenitor cells (NSCs) through the processes like neurogenesis and gliogenesis [1]. In the developed mammalian brain these NSCs have been found to be restricted to limited regions called neurogenic niches [2]. These neurogenic niches provide microenvironments for …
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Towards an understanding of the role of Ca2+ signalling in neural stem cell activation
… mammalian brain contains neural stem cells (NSCs) that are capable of brain repair, but they are mostly in a mitotically quiescent state. Identifying novel regulators of neural stem cell quiescence will provide more molecular targets for brain regeneration therapies. Drosophila melanogaster …
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Identifying regulators of neural stem cell fate and tumourigenesis
The proliferation of neural stem cells (NSCs) must be regulated precisely in order to generate a functional nervous system. Mis-regulated NSC division can lead to the inadequate production of differentiated progeny or to ectopic NSCs and tumour formation. As such, genes that promote the …
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Neural stem cell differentiation in collagen scaffolds for retinal tissue engineering
Rat neural stem cells (NSCs) were cultured in monolayer or in porous collagen scaffolds and exposed to neurogenic or non-neurogenic medium to determine the effects on neural differentiation and neurite growth. Nestin, [beta]III-tubulin, and GFAP expression were determined using immunofluorescent …
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Human neural stem cells: region-specific properties and prospects for cell therapy
… is one potential source of neural stem cells (NSCs) for cell replacement therapy in neurodegenerative disorders such as stroke. Stroke is the leading cause of disability in adult humans and treatments for beneficial and efficient recovery are today lacking. In the most common form of human …
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Evaluating the Effect of Chronic Alcohol, Cocaine, and Co-Administration on Endogenous Adult Neural Stem Cell Survival, Differentiation, and Proliferation
… by chronic drug abuse. Neural stem cells (NSCs) are a promising target to stimulate brain recovery, yet little is known about the effect of long term co-abuse of alcohol and cocaine on this cell population. Additionally, sex differences in NSC behavior following chronic drug abuse have yet …
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The Tumor-Suppressive Properties of Neural Stem Cells
… and migration of neural stem cells (NSCs) towards the tumor. This migration reflects the NSC wound repair response following CNS injury. Studies using NSCs surgically implanted into GBM tumors showed decreased tumor growth and increased animal survival in mice; however, the mechanisms …
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Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammation
… aim of this thesis was to investigate whether NSCs have the ability to regulate the immunometabolic components underpinning neuroinflammation. Herein I have identified a new mechanism by which transplanted somatic and directly-induced NSCs counteract CNS-compartmentalised chronic inflammation …
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Characteristic analysis of mobility inducers for neural stem cells
Recently neural stem cells (NSCs) were reported to migrate to damaged brain areas, such as brain tumors or ischemic regions. Systemic strategy can be effective to cancer therapeutic effect through cell-based gene therapy. From our previous studies, we identified chemoattractant molecules-1(CM-1) …
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HIV-1 INFECTION OF NEURAL STEM CELLS RESULTS IN COGNITIVE DEFICITS THROUGH ADULT NEUROGENIC MODULATION
… have demonstrated that neural stem cells (NSCs) are capable of being productively and latently infected with HIV-1. This may be due to the fact that the hippocampal subgranular zone (SGZ), the subventricular zone (SVZ), and the circumventricular organs are highly vascularized, allowing …
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Molecular mechanisms of neural stem cell plasticity and neuro-regeneration in an Alzheimer’s-like neurodegeneration model of adult zebrafish
… and neurogenic ability of neural stem cells (NSCs), which normally produce neurons, albeit rather a limited lineage. Recently, in AD patients, neurogenic outcome was shown to reduce dramatically (Moreno-Jimenez et al., 2019; Tobin et al., 2019). This lack of neurogenic input from NSCs in human …
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Dissecting the function of MYEF2 in neural stem cells and glioblastoma
… and share many properties of neural stem cells (NSCs). One feature common to both GSCs and NSCs is high expression of the transcription factor SOX2. SOX2 is known to be essential for GCS self-renewal. To understand further how SOX2 exerts its function in GSCs, the Pollard laboratory studied the …
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Systemic and local signalling regulating neural stem cell proliferation
Neural stem cells (NSCs) in the brain can be reactivated to exit quiescence and generate new cells in response to injury or disease. Determining the specific signals involved in NSC reactivation is essential to understanding neural regeneration. Investigating NSCs in *Drosophila melanogaster* …
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Understanding the role of dMob4 in postembryonic Neural Stem Cell mitotic reactivation
… cells in the brain, termed Neural Stem Cells (NSCs). In the adult brain, most NSCs exist in a quiescent state and must activate to generate new neural progeny. Understanding how NSCs balance quiescence and activation is crucial for the development of brain repair therapies. Drosophila NSCs, …
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Investigating novel direct Notch targets in Drosophila neural stem cells
… genes in different processes. Neural stem cells (NSCs) are cells that can divide and differentiate into all kinds of cells within the brain while they self-renew. Notch signalling is one of the key regulators in maintaining NSCs and performs a similar function in both Drosophila and vertebrate …
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Using single cell transcriptomics to uncover mechanisms of neural development, neural stem cell quiescence and tumourigenesis
… proper brain development. Over-proliferation of NSCs can also lead to disease, resulting in the formation of tumours. There is a delicate balance between NSC proliferation, differentiation and quiescence. Studying the mechanisms that regulate this balance is important for understanding …
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Exploring a Nuclear Insulin Receptor Signalling Pathway in Drosophila Neural Stem Cells
… tissue‐specific outputs. Neural stem cells (NSCs) give rise to the vast range of cell types that comprise the central nervous system (CNS) in a manner highly regulated in both space and time. With a comparatively simple CNS that nonetheless exhibits remarkable biological conservation, …
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Cellular and Circuit Level Responses to Neural Stem Cell Transplantation in the Rodent Cortex
… specific interactions between undifferentiated NSCs and the normal host microenvironment are not well understood. To investigate the functional impact of undifferentiated NSCs on host activity, a clonal NSC line (C17.2) was utilized. Network dynamics were monitored post-transplant in acute …
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Primitive Neural Stem Cells in the Mouse Brain
Neural stem cells (NSCs) reside in the tissue lining the lateral ventricles of the adult mouse brain. At the top of the hierarchy are primitive (p)NSCs that arise in advance of definitive (d)NSCs embryonically. After the discovery that pNSCs persist in the adult mouse brain, I sought out to …
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