Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"NS2B-NS3 Protease"”.
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Dengue virus and West Nile virus protease inhibitors
… inhibitors of Dengue Virus and West Nile Virus NS2B/NS3 protease. Structure-activity relationship studies have led to the identification of a low micromolar hit, which will be used in a hit-to-lead campaign to generate lead compounds that display superior ADMET and PK characteristics.
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Structural investigation of 1,8-dinitro-4,5-dihydroxyanthraquinone and implications for docking as a small molecule inhibitor into the protease of West Nile virus
… has shown to bind the proteases of the dengue and West Nile viruses while also reducing their titers in cell-based assays. Structure-based analog design will likely be performed in the near future to increase its activity. However, the binding mechanism and conformation …