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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 11 of 11 for “"NS1 protein"”.

  1. The Influenza A Virus NS1 Protein and Vriral mRNA Nuclear Export

    Fernandes Pereira, CarinaUniversity of Cambridge2018

    … and confocal microscopy. This identified the NS1 protein as the viral factor required for efficient segment 7 nuclear export. Mutational studies on NS1 were carried out to unveil the mechanistic role of this protein in viral mRNA nuclear export, by plasmid transfection as well as in the …

    cambridge Repository record

  2. The role of the interaction of the influenza B virus NS1 protein with the cellular Brd2 protein

    Park, Jang WonThe University of Texas at Austin2009

    … infection per year. The effector domain of the NS1 protein of influenza B virus (NS1B protein), encompassing the carboxy terminal two thirds of the protein, suppresses interferon-β (IFN-β) synthesis in virus-infected cells by unknown mechanism(s). The induced IFN-β mediates innate immunity. To …

    texas Repository record

  3. Molecular biology of segment 8 of the influenza A virus genome

    Arikainen, ArturUniversity of Cambridge2022

    … and 2) interactions of the viral non-structural protein translated from this segment – NS1 – with a host cell protein during infection. 1) The genome of influenza A virus is packaged into virions as negative sense viral RNA. To date, all known viral proteins are encoded in the positive sense. A …

    cambridge Repository record

  4. Untersuchung Influenza Virus-induzierter Signalprozesse und deren Bedeutung in der Wirtszell-Abwehr

    Ehrhardt, ChristinaUniversität Würzburg

    … von Zellen mit einem Virus, dem das virale NS1 Protein fehlt, welches RNA binden und somit "wegfangen" kann, eine gesteigerte JNK Aktivität im Vergleich zu den Kontroll-Infektionen. Damit konnte das NS1 Protein als erstes virales Protein identifiziert werden, das der Virus- und …

    wurz-thes Repository record

  5. NS1 of H5N1 Interacts with SAP-97 in a PDZ-dependent Manner to Disrupt Epithelial Barrier Integrity

    Conoley, Veronica Garcia2016

    … influenza A viruses revealed that nonstructural protein 1 (NS1) contains a class I PDZ motif. The NS1 proteins of avian origin contain the PDZ motif ESEV, which has been found to bind several cellular PDZ domain proteins. The interaction of NS1 and host proteins via the PDZ motif is a determinant …

    tenn-hsc Repository record

  6. Functional analysis of glycosylation of Zika virus envelope and NS1 proteins

    Fontes-Garfias, Camila RThe University of Texas Medical Branch at Galveston2021

    … syndrome. ZIKV has two important glycoproteins, both the envelope (E) protein, and nonstructural protein 1 (NS1). The ZIKV envelope (E) protein is responsible for viral entry and represents a major determinant for viral pathogenesis. NS1 forms a homodimer necessary for viral replication …

    utmb Repository record

  7. Functional analysis of glycosylation of Zika virus envelope and NS1 proteins

    Fontes-Garfias, Camila RThe University of Texas Medical Branch at Galveston2021

    … syndrome. ZIKV has two important glycoproteins, both the envelope (E) protein, and nonstructural protein 1 (NS1). The ZIKV envelope (E) protein is responsible for viral entry and represents a major determinant for viral pathogenesis. NS1 forms a homodimer necessary for viral replication …

    utmb Repository record

  8. Metabolomics-based diagnosis and prognosis of dengue virus infections and NS1 antigen detection for diagnosis and surveillance in humans and mosquitoes

    Voge, Natalia Victoria, author, Blair, Carol D., advisor, Beaty, Barry J., advisor, Loroño-Pino, Maria A., committee member, Eisen, Lars, committee member, Belisle, John T., committee member, Prenni, Jessica E., committee memberColorado State University. Libraries2013

    … epidemics for vector control. Non-structural protein 1 (NS1) detection by ELISA is a commercially available test with the ability to detect DENV NS1 protein in DENV infected samples. Studies were conducted to determine the ability of the NS1 antigen test to detect DENV in Aedes aegypti …

    colostate Repository record

  9. Characterization of Candidate Mutations for Use in a Live Attenuated West Nile Virus Vaccine

    Kaiser, Jaclyn AThe University of Texas Medical Branch at Galveston2022

    … investigated in the envelope (E), NS4B, and NS5 proteins. Additionally, multigenic mutants were investigated that combined mutations in the NS1 protein with mutations in the E or NS4B proteins, as a vaccine with multigenic mutations should have fewer chances of reversion to virulence. The E …

    utmb Repository record

  10. Molecular insights into modulation of host innate immune response by viral proteins of RNA viruses SARS-CoV, HCV and Influenza virus

    SANTHANA GOWRI N/A THANGAVELU DEVARAJThe University of Texas Medical Branch2009

    … Finally, my studies with influenza virus NS1 protein demonstrate that NS1 antagonizes the IFN response by blocking RIG-I activation in a strain specific manner. In conclusion, I have made an attempt to understand the complex antiviral signaling pathways at the cellular level in context to …

    utmb Repository record

  11. ISG15 conjugation : cellular targets and the lysine selectivity of HERC5

    Zhao, Xu, Ph. D.The University of Texas at Austin2023

    ISG15 is a 17 kDa ubiquitin-like protein that functions in the innate immune response to pathogens. While human ISG15 is a multifunctional protein, its canonical function is that of an intracellular ubiquitin-like protein modifier. Like ISG15, the human E1 (UBE1L), E2 (UBE2L6) and E3 (HERC5) …

    texas Repository record