Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"NS1"”.
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The Role of NS1-BP in Influenza Virus Replication
… have shown that the non-structural protein (NS1) of influenza A virus is a major virulence factor that is essential for pathogenesis. NS1 is a multifunctional protein localized in the nucleus and in the cytoplasm. In the cytoplasm, NS1 inhibits host signaling pathways that result in …
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Funktion des SGT/NS1-Komplexes im Lebenszyklus autonomer Parvoviren
… als Interaktionspartner des hauptregulatorischen NS1-Proteins des autonomen Parvovirus H1 identifiziert. Es akkumuliert nach Infektion zusammen mit NS1 in APAR-Bodies, den Orten der parvoviralen Replikation. Darüber hinaus wird SGT NS1-abhängig modifiziert. Diese Befunde ließen vermuten, daß SGT …
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Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
… (E) protein, and nonstructural protein 1 (NS1). The ZIKV envelope (E) protein is responsible for viral entry and represents a major determinant for viral pathogenesis. NS1 forms a homodimer necessary for viral replication and it is also secreted as a hexamer and is involved in immune system …
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Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
… (E) protein, and nonstructural protein 1 (NS1). The ZIKV envelope (E) protein is responsible for viral entry and represents a major determinant for viral pathogenesis. NS1 forms a homodimer necessary for viral replication and it is also secreted as a hexamer and is involved in immune system …
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The Influenza A Virus NS1 Protein and Vriral mRNA Nuclear Export
… and confocal microscopy. This identified the NS1 protein as the viral factor required for efficient segment 7 nuclear export. Mutational studies on NS1 were carried out to unveil the mechanistic role of this protein in viral mRNA nuclear export, by plasmid transfection as well as in the …
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Characterisation and analysis of the NS1 gene of tick-borne encephalitis virus
… a highly immunogenic ncnstructural glycoprotein, NS1. The proposed NS1 gene from the TE V strains Neudörfl and K23 was identified, cloned and sequenced. The NS1 gene from the Neudorfl strain of TBEV was then cloned under the powerful constitutive cytomegalovirus (CMV) major immediate-early …
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The role of the interaction of the influenza B virus NS1 protein with the cellular Brd2 protein
… infection per year. The effector domain of the NS1 protein of influenza B virus (NS1B protein), encompassing the carboxy terminal two thirds of the protein, suppresses interferon-β (IFN-β) synthesis in virus-infected cells by unknown mechanism(s). The induced IFN-β mediates innate immunity. To …
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NS1 of H5N1 Interacts with SAP-97 in a PDZ-dependent Manner to Disrupt Epithelial Barrier Integrity
… A viruses revealed that nonstructural protein 1 (NS1) contains a class I PDZ motif. The NS1 proteins of avian origin contain the PDZ motif ESEV, which has been found to bind several cellular PDZ domain proteins. The interaction of NS1 and host proteins via the PDZ motif is a determinant in the …
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Identifizierung und Charakterisierung von Interaktionen der Nichtstrukturproteine NS1 und NS2 des Respiratorischen Synzytialvirus mit Proteinen der Wirtszelle
… Virus (RSV) encode two nonstructural proteins, NS1 and NS2. These two proteins cooperatively mediate type I interferon resistance and prevent induction of interferon in infected cells. Interactions of NS1 and NS2 proteins in every combination were shown by using the yeast-two-hybrid system. …
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Genetic and cytological investigation of Nucleostemin-1 in Drosophila melanogaster
… contains a four-member nucleostemin family (NS1-4). Nucleostemin 1 (NS1) is the closest orthologue to human NS; it shares 33% identity and 67% similarity with human NS. We show that NS1 has intrinsic GTPase and ATPase activity, and that it is present within nucleoli of most larval and adult …
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Of Mice and Men and Cattle: Functions of the Pneumovirus Nonstructural Proteins NS1 and NS2 in Interferon Escape
… of two unique nonstructural protein genes, NS1 and NS2. We show that both BRSV NS proteins are necessary and sufficient to mediate IFN resistance. This function can also be transferred to another, unrelated virus, Rabies virus. The mechanism of IFN resistance is conserved among the …
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Expressão das proteínas não-estrutural 1 (NS1) dos vírus Dengue-1, Dengue-3 e Dengue-4 em Pichia pastoris
… especialmente a proteína não estrutural 1 (NS1), é uma alternativa muito eficaz para realizar o diagnóstico da dengue. Essa proteína é sintetizada pelas células infectadas, podendo ser detectada nos sobrenadantes das culturas ou no soro de pacientes infectados. Dessa forma, ela pode ser …
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DNA Binding Protein’s Structure, Mechanism, and Functional Relevance; From Filament Formation of SgrAI to Helicase Activity of B19V-NS1
… on which I worked was the nonstructural protein (NS1) of human parvovirus B19. It is hypothesized that this protein possesses helicase activity in its central domain. In this study, I analyzed the isolated central domain of B19V-NS1 and investigated its helicase activity on non-specific and …
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Delineating the Mechanisms of Misfolded Endoplasmic Reticulum (ER) Luminal Protein Retrotranslocation for ER-Associated Degradation
… non-secreted immunoglobulin (Ig) κ light chain (NS1 κ LC), which is composed of a poorly folded N-terminal domain and a well-folded C-terminal domain was used in the biotinylation assays. NS1 was modified at either the N- (BAP-NS1) or C- (NS1-BAP) terminus with a biotin acceptor peptide (BAP) …
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Metabolomics-based diagnosis and prognosis of dengue virus infections and NS1 antigen detection for diagnosis and surveillance in humans and mosquitoes
… for vector control. Non-structural protein 1 (NS1) detection by ELISA is a commercially available test with the ability to detect DENV NS1 protein in DENV infected samples. Studies were conducted to determine the ability of the NS1 antigen test to detect DENV in Aedes aegypti mosquitoes. The …
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Funktionelle Bedeutung der Protein-Kinase C eta im Infektionszyklus des autonomen Parvovirus Minute Virus of Mice
Das multifunktionale große Nichtstruktur Protein NS1 des autonomem Parvovirus Minute Virus of Mice (MVM) wird posttranslational modifiziert und zumindest teilweise über Phosphorylierung reguliert. Aufgrund seiner enzymatischen Funktionen, wie die ATPase-, Helikase- und Nickase-Aktivitäten ist NS1 …
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Molecular biology of segment 8 of the influenza A virus genome
… protein translated from this segment – NS1 – with a host cell protein during infection. 1) The genome of influenza A virus is packaged into virions as negative sense viral RNA. To date, all known viral proteins are encoded in the positive sense. A large open reading frame exists on …
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THE ROLE OF GENETIC VARIANTS OF NON-STRUCTURAL PROTEIN 1 IN DENGUE PATHOGENESIS
… form of dengue non-structural protein 1 (sNS1) can cause vascular leakage, a hallmark of severe disease. This work explored several genetic variants of NS1 present in the viral population with an emphasis on T164S mutation that has been associated with increased intraepidemic disease …
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INVESTIGATING THE ROLE OF DENGUE-SPECIFIC IMMUNITY IN PROTECTION AND DISEASE USING SYMPTOMATIC MOUSE MODELS
… we established that the pathogenic role of NS1 and NS1-mediated-immunity protection are DENV strain-dependent.
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