Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"NRTI"”.
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Probing the HIV reverse-transcriptase enzyme with novel bifunctional HIV-1 RT inhibitors of the general formula (NRTI)-spacer-(NNRTI)
… of resistance elicited by both nucleoside (NRTI) and non-nucleoside (NNRTI) reverse transcriptase inhibitors have prompted the design of double-drugs combining these two entities with the aim of addressing the emergence of resistance as well as searching for synergism between the two drug …
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Probing the HIV Reverse-Transcriptase enzyme with novel bifunctional HIV-1 RT inhibitors of the general formula (NRTI)-spacer-(NNRTI)
… of resistance elicited by both nucleoside (NRTI) and non-nucleoside (NNRTI) reverse transcriptase inhibitors have prompted the design of double-drugs combining these two entities with the aim of addressing the emergence of resistance as well as searching for synergism between the two drug …
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Investigating Mechanisms of Nucleoside Reverse Transcriptase Inhibitor Induced Sensory Neuropathy
… the nucleoside reverse transcriptase inhibitors (NRTIs) used in the ART are thought to contribute to PSN, the mechanisms underlying the PSN induced by NRTIs are unclear. This is partly due to the lack of a good model for mechanistic investigations. In this study, we developed a Drosophila model …
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Cost effectiveness analysis of two alternative interventions for the integration of Tenofovir into South Africa's public sector First Line Antiretroviral treatment regimen
… reverse transcriptase enzyme inhibitors (NRTI) with one non-nucleoside reverse transcriptase inhibitor (NNRTI) while the second line regimen is based on a protease inhibitor (PI) with two NRTIs. Similar to many developing countries, South Africa's NRTI backbone in the first line treatment …
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Whole Blood Mitochondrial DNA Depletion in Human Immunodeficiency Virus-Infected Children
… Nucleoside reverse transcriptase inhibitors (NRTIs) interfere with mitochondrial DNA polymerase gamma causing significant toxic effects, including fatal lactic acidosis. Little is known about mitochondrial DNA (mtDNA) in human immunodeficiency virus (HIV) infected children who face a lifetime …
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Die Bedeutung der Proteasehemmer-Plasmakonzentration für das Lipodystrophiesyndrom bei Patienten mit HIV-Infektion unter HAART
… Kombination mit Substanzen der Nukleosidischen- (NRTI) und Nicht-Nukleosidalen-Reverse-Transkriptase-Inhibitoren (NNRTI) eingenommen werden. Nach Einführung einer solchen HAART trat ein bisher ätiologisch unbekannter Symtpomenkomplex auf, den man vor allem mit den Proteaseinhibitoren in Verbindung …
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Prevalence and incidence of hypertension and diabetes mellitus in HIV infected persons on HAART in Chongwe district in Lusaka province.
… mellitus. HAART combination regimen of two NRTI classes plus either a PI or INSTI were associated with higher incidence of hypertension whilst combination regimens of two NRTIs plus an NNRTI or INSTI and combination therapy of NRTI+NNRTI+INSTI were associated with higher incidence of type II …
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Prevalence and incidence of hypertension and diabetes mellitus in HIV infected persons on HAART in Chongwe district in Lusaka province.
… mellitus. HAART combination regimen of two NRTI classes plus either a PI or INSTI were associated with higher incidence of hypertension whilst combination regimens of two NRTIs plus an NNRTI or INSTI and combination therapy of NRTI+NNRTI+INSTI were associated with higher incidence of type II …
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Synthesis and anti-HIV activity of [d4U]-spacer-[HI-236] bifinctional HIV-1 reverse transcriptase inhibitors
… linkedvia different spacers between C-5 of the NRTI and 0-1 of the NNRTI. Three targets were successfully synthesized in a divergent manner from uridine in 13steps for the butyne target and 19 steps for targets bearing PEG-propyne units usingSonogashira coupling as a key step. The most …
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Pharmacogenomics and pharmacokinetics of dolutegravir and tenofovir in Southern Africans living with HIV
… a nucleos(t)ide reverse transcriptase inhibitor (NRTI) backbone as the preferred first-line regimen for people living with HIV (PLWHIV) initiating antiretroviral therapy (ART). Tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) are both prodrugs of tenofovir. However, plasma …
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Design and synthesis of novel sulfur-containing antiviral analogues
… the nucleoside reverse transcriptase inhibitor (NRTI) class of anti-HIV compounds is described in Chapter Two. Our proposed synthetic target, an analogue of Adefovir Dipivoxil, is described alongside our rationale for studying this compound. Chapter Three details the model study which we …
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Human immunodeficiency virus type 1 diversity in patients initiating treatment in Northern South Africa
… non-nucleoside reverse transcriptase inhibitor (NNRTI) had a 7.5% prevalence within the >20% threshold and 8.7% prevalence within >5% threshold. The NNRTI SDRMs that chiefly contributed to this prevalence at >20% threshold were K103N (6.2%; 15/241), V106M (1.7%; 4/241) and P225H (1.2%; 3/241) …
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Characterization of and risk factors for HIV-1 resistance mutations following first line antiretroviral failure in the southern African private sector
… non-nucleoside reverse transcriptase inhibitor (NNRTI) regimen with no history of prior failure on a protease inhibitor (PI) regimen were included: 265 (95.3%) patients had a reverse transcriptase mutation of any kind, 253 (91%) had an NNRTI mutation and 246 (88.5%) had a nucleoside reverse …
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Morbidity from antiretroviral metabolic effects in Africa: The Mama Study
… nonnucleoside reverse transcriptase inhibitor (NNRTI) in first-line antiretroviral therapy (ART) regimens in low- and middle-income countries, where the prevalence of diabetes is increasing. Randomized control trials have shown mild increases in plasma glucose in participants in the efavirenz …
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Elucidating the mechanisms and dynamics of drug-mediated inhibition and latency reversal in HIV-1 (HIV-1)
… Reverse Transcriptase Inhibitors (NNRTIs), and LRAs, to better understand the mechanisms by which each drug class inhibits and reactivates HIV-1 replication respectively, to aid in the effort towards the development of antivirals that will lead to HIV-1 eradication. Chapter II …
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Drug Resistance Mutations in Naive HIV-1 South African Patients, and Construction of Molecular Clones to Phenotype Putative Resistance Mutations
… test showed that the vectors can be inhibited by NRTI, NNRTI and Pl. Inhibition was seen in all drugs in different concentrations indicating that the system works. The results showed that vector systems constructed can be used to evaluate putative drug resistant mutations, coding for resistance to …
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Evaluation of adherence to antiretroviral therapy using efarivenz as a marker
… revealed the absence of major mutations in both NRTI and NNRTI drug classes. The G516T polymorphism was present in 15% of the study participants while the homozygous GG and heterozygous GT genotype was present in 25% and 40% of the study participants, respectively. Allele determination was …
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Synthesis of phosphorus/sulfur-based antivirals
The Human Immunodeficiency Virus is a major global health problem. Although a number of effective combination therapies are available, drug resistance remains an ongoing concern due to the rapid mutation rate of the virus. Novel antivirals are continually required to combat evolving resistance. By …