Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"NRG1"”.
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Discovery of Immunogenic Neo-peptides from Actionable RNA Fusion CD74-NRG1 for Developing Cancer Vaccines
This study investigates the CD74-NRG1 fusion protein as a tumor-specific neoantigen source and presents a comprehensive pipeline for identifying and validating immunogenic neoantigens from chimeric RNAs, with promising implications for personalized cancer vaccines. The CD74-NRG1 fusion, resulting …
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Roles Of Neuregulin1 In Neuromuscular Junction Development
… derived from every cell type. Neuregulin1s (NRG1s) are a family of predominantly neuronal growth and differentiation factors that are important for many aspects of nervous system development. In this thesis, both the effects of NRG1 on NMJ development and reciprocal effects of neurotrophic …
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Axogial communication mediated by soluble neuregulin-1 and bdnf
… proteins belonging to the neuregulin1 (NRG1) gene family of growth and differentiation factors are essential for Schwann cell survival and peripheral nerve development. While membrane-bound NRG1 forms (type III) has been strongly implicated in the regulation of myelination process at …
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Tetracycline-dependent gene expression in cholinergic neurons of transgenic mice : a tool to study Neuregulin-1 function in vivo
… model permitting the analysis of neuregulin-1 (NRG1) function in the adult nervous system. NRG1 is a polypeptide growth factor, which contains an ‘epidermal growth factor like’ (EGFL) domain and serves as a ligand for the erbB receptor tyrosine kinase family. Alternative splicing of the NRG1 …
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Effects of diet on behavioural domains relevant to schizophrenia- a preclinical perspective
… models for the genetic risk factor neuregulin 1 (NRG1), the transmembrane domain Nrg1 (Nrg1 TM HET) and the Nrg1 type III (Nrg1 III tg) models, and how HFD in a maternal obesity model in C57BL/6J mice can modify schizophrenia-relevant behaviours. HFD increased body weight over time in all mice. …
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Molecular and cellular mechanisms of cortical functional regeneration through diterpenoid-induced neurogenesis
… into existing circuits. EOF2 also elevated NRG1 expression in the cortex and SVZ in vivo and stimulated its release from neural precursors in vitro, supporting a model in which EOF2 modulates NRG1 availability to favour SVZdriven neurogenesis and neuronal maturation in the injured brain. We …
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Molecular characterization of three mental illness susceptibility genes
… thesis were to focus on three candidate genes: NRG1, ST8SIA2 and NCAM1, each associated with psychotic mental illness, and determine how these genes could be functionally involved in disease susceptibility. Working with case-control cohorts, analysis of the target genes was undertaken at the …
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Targeting Stromal-Mediated Resistance Mechanisms in Oncogenic KRAS-Driven Pancreatic Ductal Adenocarcinoma
… demonstrates that stromal-derived Neuregulin 1 (NRG1) activates upregulated ERBB2/3 receptors on cancer cells following KRAS inhibition, establishing a critical resistance pathway. Second, optimize tissue dissociation methodology was proposed for PDAC specimens, overcoming barriers created by the …
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Molecular Analysis of Phenotypic Diversity in Human Fungal Pathogens
… in a transcriptional repressor of filamentation, NRG1. These mutants were resistant to the filament inhibitory effects of Pseudomonas aeruginosa, implicating interkingdom interactions as the driver of adaptation. Second, I characterized the role of the molecular chaperone Hsp90 in drug resistance …
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Development of a Neoepitope Prioritization Platform to Identify Immunogenic Neoantigens from Oncogenic FGFR3-TACC3 Fusion in Glioblastoma
… dataset comprising FGFR3-TACC3, CD74-NRG1, and ESR1-PRKN across multiple HLA alleles, improving predictive robustness and specificity. Functional validation using ELISpot assays demonstrated that 9 of 10 fusion derived in vitro validated binders induced significant IFN-γ secretion from …
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Tor Signaling in the Fungal Kingdom
… several transcriptional regulators (Bcr1, Efg1, Nrg1, and Tup1) that together with Tor compose a regulatory network governing adhesin gene expression and cellular adhesion. While the Tor kinases are broadly conserved, these studies further demonstrate the contrasting strategies employed by fungal …
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The Nrg Growth Factors and Their Receptor ErbB4 in the Developing Brain: Delineation of Nrg3 Expression and Neuritogenesis
… The neuregulin (Nrg) family of growth factors (Nrg1-4) and their receptor, ErbB4, have been linked to mental illnesses considered to emerge as a result of abnormal neural development, such as schizophrenia, bipolar disorder, and depression. In the normal central nervous system (CNS), Nrg-ErbB …
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Improving Thermodynamic Models of Transcription by Combining ChIP and Expression Measurements of Synthetic Promoters
… adversely affected by the presence of a nearby Nrg1 site. Finally, the occupancy data and expression data taken together suggest that Gcn4 binds in competition with another transcription factor.</p><p>Synthesizing disparate sources of information resulted in an improved understanding of the …
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Genetic programming of human iPSC-derived macrophages provides a tool to study the Erythroblastic Island niche in vitro
… Pilot studies revealed that secreted factors NRG1, IGFBP6, CCL13 and TNFSF10 could also play a role in the later stages of the erythroid differentiation protocol. To our knowledge, this is the first time that macrophage phenotype and function have been manipulated by transcription factor …