Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 131 for “"NRF2"”.
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TARGETING THE NRF2/KEAP1 INTERACTION
The Nrf2/Keap1 protein-protein interaction (PPI) regulates activity of the Nrf2 antioxidant and anti-inflammatory pathway. The transcription factor Nrf2 has been found to be a key mediator in the resolution of inflammation and the progression of chronic diseases. Most known inducers of the Nrf2 …
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Discovery and Design of NRF2 Modulators
Nuclear factor erythroid 2–related factor 2, or NRF2, is a key protein responsible for the regulation of numerous signaling pathways in the body, particularly those related to oxidative stress and cytokine release. As such, reduced NRF2 activity has been identified as a contributing factor of …
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Targeting Nrf2 in Inflammation and Cancer
The transcription factor Nrf2 protects against cellular stress by inducing cytoprotective proteins. Activation of Nrf2 protects against inflammation and oxidative damage in disease models in vitro and in vivo. Nrf2 activation may be a good therapeutic strategy in these diseases. Some dietary …
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Characterisation of Nrf2-signalling and the effects of boosting astrocytic Nrf2 in a mouse model of ischaemic stroke
… Factor Erythroid 2 (NFE2)- Related Factor 2 (Nrf2) is a transcription factor and master regulator of a battery of antioxidant and anti-inflammatory genes such as Heme oxygenase-1 (hmox1), NAD(P)H dehydrogenase quinone 1 (nqo1), glutamate-cystine antiporter (xCT; gene slc7a11), sulfiredoxin 1 …
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Single cell analysis of Keap1-Nrf2 dynamics
The transcription factor Nrf2 is a master regulator of cytoprotective gene expression. Nrf2 is negatively controlled by Keap1, a sensor protein which allows Nrf2 to respond to changing cellular conditions. In the basal state, Nrf2 binds to two sites of a Keap1 dimer allowing its ubiquitination in a …
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ANALYSIS OF ELECTROPHILE-INDUCED NRF2 GENE ACTIVATION
Activation of the transcription factor Nrf2 regulates expression of phase II enzymes and other adaptive responses to electrophile and oxidant stress. Nrf2 concentrations are regulated by the thiol-rich sensor protein Keap1, which is an adaptor protein for Cul3-dependent ubiquitination and …
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Nrf2 in metabolic related inflammation in the brain
… (OS). Disruption of NF-E2-related factor 2 (Nrf2) signalling increases OS and promotes AD. Amyloid precursor protein (APP) is intimately linked with AD, with the Swedish mutation (<i>hAPP<sub>swe</sub></i>) used in numerous transgenic models. Furthermore, increasing importance has been placed …
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Investigating the role of the Nrf2-Keap1 pathway in mitophagy
… conditions. Interestingly, another pathway, the Nrf2-Keap1 pathway, which acts as sensor for stress within the cell, is also activated and mediates several cytoprotective functions, including redox and intermediary metabolism homeostasis, and autophagy. Studies have also indicated crossover …
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The regulation of mouse embryonic stem cell differentiation by Nrf2
… Nuclear factor erythroid 2-related factor 2 (Nrf2). Therefore, this study investigate relationship between metabolism, ROS, and Nrf2 during mouse ES cell differentiation. In vitro models representing early lineage differentiation were used. By measuring metabolic profiles, ROS, and Nrf2 levels …
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An autoregulatory loop between NRF2 and HIPK2 shapes cytoprotective responses
… 2)-like 2, known as NFE2L2 (gene) or NRF2 (protein), is the primary cellular barrier to counteract the deleterious effects of oxidative stress. NRF2 is a transcription factor that regulates the basal and inducible expression of hundreds of cytoprotective genes to enable cells to adapt …
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The Temporal and Contextual Relationship of NRF2 Activation and Cancer
The complex role of NRF2 in the context of cancer continues to evolve. As a transcription factor, NRF2 regulates various genes involved in redox homeostasis, protein degradation, DNA repair, and xenobiotic metabolism. As such, NRF2 is critical in preserving cell function and viability, particularly …
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Μελέτη του μεταγραφικού παράγοντα NRF2 ως διαμεσολαβητή της δράσης των στατινών
… ιδιαίτερα στις αντιοξειδωτικές τους δράσεις. Ο Nrf2 (NF-E2-related factor 2) είναι ένας μεταγραφικός παράγοντας που ενορχηστρώνει τη μεταγραφική απάντηση των κυττάρων στο οξειδωτικό στρες και σε ηλεκτροφιλικά ξενοβιοτικά με την έκφραση αντιοξειδωτικών-κυτταροπροστατευτικών γονιδίων. Στην παρούσα …
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Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression
… since the discovery of the important role that NRF2 plays in regulating the expression of phase II drug metabolism genes, NRF2 has been a highly studied therapeutic target. NRF2 signalling is often elevated in lung cancer due to mutations in NFE2L2, the gene that encodes NRF2; and KEAP1, the …
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Exosome-Mediated Protection Against Oxidative Stress: A Connection Between NRF2 And Exosomes
… factor erythroid 2 (NF-E2)-related factor 2 (NRF2) transcription factor has been widely studied for its role as the master regulator of the response to oxidative stress. NRF2 has many mechanisms for protection including upregulation of antioxidant genes, metabolism genes, and proteolysis …
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Is there an association between S1P signaling and the transcription factor Nrf2?
… factor-erythroid 2 [NF-E2]-related factor 2 (Nrf2) is a transcriptional activator that can offer protection to cells. By activating cytoprotective genes, Nrf2 can help cells to defend against DNA damage, electrophilic and oxidative stress. However, Nrf2 can also act as an oncogene. The …
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THE ROLE OF NRF2 IN PREVENTING OXIDATIVE/ELECTROPHILIC STRESS-INDUCED LIVER INJURY
… Nuclear factor, erythroid derived 2, like 2 (Nrf2) is a master regulator of biochemical mechanisms that respond to oxidative/electrophilic stress. Under basal conditions, Nrf2 is held in an inactive state in the cytoplasm by binding to the cytoskeletal anchoring protein Kelch-like …
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Investigating the role of transcription factor Nrf2 in the pathogenesis of NAFLD
… nuclear receptor (erythroid-derived 2)-like 2 (Nrf2) is a master regulator that orchestrates the response to oxidative stress by inducing expression of cytoprotective genes. Understanding interactions between oxidative and ER stress may allow further understanding of the pathogenesis of …
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Regulation of transcription factors NRF2 and HSF1 in mediating cellular stress responses
The KEAP1/NRF2/ARE pathway is at the forefront of cellular defense. Induction of this pathway is protective against various conditions of stress such as oxidative stress and exposure to electrophiles. Conversely, failure to upregulate the pathway leads to increased disease susceptibility and …
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Upregulation of heme oxygenase-1 and activation of Nrf2 by the phytochemicals in protandim
… of nuclear factor E2 p45-related factor 2 (Nrf2), and protection from oxidative stress induced apoptosis. In cultured cardiomyocytes, treatment with Protandim was associated with activation of Nrf2 and a significant increase in HO-1. Protandim supplemented cells were protected against …
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