Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"NRF1"”.
-
Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
… TFAM was accompanied with increased PGC-1α and NRF1 expressions through the activations of LKB1 and AMPK due to increased activity of PKCζ in old cells. These signaling pathways are important in regulating the mitochondrial encoding OXPHOS complex subunit genes and respiration as well as ATP …
-
The effect of 10 days of heat acclimation on submaximal exercise economy and efficiency at 1600 m and 4350 m
… Heat stress also significantly increased PGC-1α, NRF1 and TFAM leading to increased mitochondrial content. These data demonstrate that while heat stress reduces UCP3 expression, thereby reducing uncoupling and leading to enhanced mitochondrial efficiency, these adaptations are not observed in the …
-
In vitro investigation of the molecular relationship between mitochondrial dysfunction and neurogenesis in autism aetiology
… biogenesis (mitogenesis) (C-MYC, PGC-α, NRF1, NFE2L2, TFAM) and mitochondrial fusion (STOML2, OPA1) genes were performed to identify PPA-responsive genes and to get initial insights on the effect of PPA treatments on transcriptional regulation of mitostasis. Mitochondrial membrane …
-
ELUCIDATION OF MECHANISMS GENERATING 5-HYDROXYMETHYLCYTOSINE (5hmC) IN MAMMALIAN MITOCHONDRIA
… sequence. mtDNMT1 expression is upregulated by NRF1 and PGC1α, master regulators of mitochondrial biogenesis and function, as well as by loss of p53. Altered mtDNMT1 expression asymmetrically affects mtDNA transcription. We are now pursuing the role of Tet proteins in generating 5hmC in mtDNA. …
-
Functional consequences of cytosine methylation in mitochondrial DNA catalyzed by DNA methyltransferase 1
… analog 5-aza-2’-deoxycytidine (5-aza-dC). NRF1 and PGC1α, transcription factors that activate nuclear-encoded mitochondrial proteins in response to oxidative stress, were observed to up-regulate expression of mtDNMT1. Loss of p53, a tumor suppressor gene known to help control mitochondrial …
-
Molecular regulation of the cardiac-enriched acetyl-CoA carboxylase isoform (ACCβ) : a novel target for therapeutic interventions in cardiovascular disease
… acid cycle, and b) nuclear respiratory factor 1(NRF1) - the hypothesis being that this mitochondrial biogenesis and β-oxidation enhancing modulator would be expected to attenuate ACCβ promoter activity in order to increase fatty acid oxidation capacity.
-
Mitochondrial mechanisms in autism spectrum disorder: characterizing the neurotoxic effects of propionic acid in vitro
… metabolism (PGC1α, c-MYC), biogenesis (TFAM, NRF1), fission (DRP1) and fusion (STOML2, MFN1/2, OPA1). Confocal microscopy demonstrated associated disruptions to mitochondrial network morphology and integrity, characterised by decreased mitochondrial volume, increased mitochondrial …
-
EFFECTS OF HISTONE DEACETYLASE INHIBITORS ON ENERGY METABOLISM
… factors or coactivators (e.g., PGC-1α, NRF1, Tfam) have been associated with this process. Notably, skeletal muscle differentiation and remodelling are also controlled at the epigenetic level, via transcriptional modulation of key genes in mitochondrial biogenesis and oxidative …
-
Resveratrol Analogs: Potential Chemopreventive Agents in Breast Cancer
… nuclear factor erythroid 2- related factor 1 (Nrf1) and nuclear factor erythroid 2-related factor 3 (Nrf3). We also investigated the potential roles of Res-analogs in prevention of epithelialmesenchymal transition (EMT). An epithelial-mesenchymal transition can be defined as a biological …