Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"NR4A1"”.
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The Roles of Nuclear Receptor NR4A1 in Cancer Cell Proliferation and Skeletal Muscle Differentiation
… modulate expression of target genes. NR4A1 (Nur77) is a member of the NR4A family of nuclear receptors and displays an oncogenic profile in many cancer models. It is often upregulated in adult solid malignancies and is known to promote cell proliferation and survival. Knockdown studies …
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Investigating the Regulation and Function of the NR4A Nuclear Receptors in Cancer
… NR subfamily 4A (NR4A), which includes the NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor-1) genes, has been implicated in adult solid tumors and has been characterized as pro-tumorigenic mediator of cell proliferation, transformation, migration, and drug resistance. Alternatively, in …
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Knowledge-Guided Machine Learning for Single-Cell Regulatory Genomics
… and supporting a pro-inflammatory role for NR4A1 with in vivo validation. Third, we introduce scRegulate, a VAE that embeds TF-target priors to infer TF activities and context-specific regulatory networks from scRNA-seq, with benchmarking demonstrating improved recovery of perturbation …
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Identify the regulatory roles of intestinal secretory cell lineages during gut inflammation
… inflammation, noting a significant increase in NR4A1 expression, which triggered immediate early genes (IEGs) activating the ATF4-ATF3 stress response pathway. Notably, changes in serotonin dynamics, including increased levels and serotonylation, were observed, suggesting that serotonylation may …
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Sympathetic Neural Control of Inflammation by ADRB2-Mediated IL-10 Secretion
… signaling. Additionally, mice that deficient in NR4A1 are susceptible in LPS endotoxemia model. These results suggest a novel pathway for control of inflammation via neuroendocrine cues. Understanding this pathway will provide new insights into how the nervous and immune systems communicate …
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Effects of close-up dietary energy strategy and prepartal dietary monensin on hepatic mRNA expression of enzymes involved in glucose and lipid metabolism in transition cows
… IGF1) and transcription factors (FOXA2, HNF4A, NR4A1, SREBPF2). In cows fed the CON diet, serum NEFA concentrations were higher at -2 and -1 week relative to calving and serum BHBA concentrations were also higher at -2 wk. We also observed a lower concentration of BHBA in cows fed monensin at 2 …
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Role of miR-19a-3p and miR-19b-3p in microglia activation and neuroinflammation
… neuroprotective genes Nurr1 (Nr4a2) and Nur77 (Nr4a1) following microglia activation and SCI. Results: Findings from Aim 1 revealed that mimics of miR-19a or miR-19b enhanced microglia activation, indicated by increased pro-inflammatory cytokine expression and decreased SOCS1 and SOCS3 …
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PERINATAL SEROTONERGIC MANIPULATION SHAPES LONG-TERM NEUROPSYCHIATRIC-LIKE PHENOTYPES IN RATS: MOLECULAR INSIGHTS ACROSS THE LIFESPAN.
… indotto dallo stress acuto, dell'espressione di Nr4a1 e Dusp1 nella corteccia prefrontale (PFC), indicando perturbazioni più ampie nei sistemi correlati allo stress oltre l'asse HPA. Nell'ultima parte del mio progetto di dottorato, abbiamo esplorato l'ipotesi che la manipolazione serotoninergica …
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A novel antigen-receptor signalling reporter mouse reveals clonotype-independent intratumoral trapping as a spatial feature of CD8+ T cell exhaustion
… mouse, that uses the specificity of Nur77 (NR4A1) for antigen receptor activation to drive expression of a tamoxifen-inducible CreERT2, enabling time-stamping of TCR-activated lymphocytes with EYFP expression through a Cre-LoxP mechanism. This allows multiple clonal lymphocytes and their …