Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"NR2B"”.
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Domains of the NR2A and NR2B subunits involved in NMDA receptor current modulation by PKC.
Domains of the NR2A and NR2B subunits involved in NMDA receptor current modulation by PKC.
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SÍNTESE DE NOVOS POTENCIAIS ANTAGONISTAS DO NMDA SUBTIPO NR2B DO SISTEMA NERVOSO CENTRAL BASEADOS EM CARBOXAMIDAS TRIAZÓLICAS
In this work were investigated the preparations of new amines and amides 1,2,3 - and 1,2,4 - triazoles, which were viewed as intermediates in the syntheses of new amino carboxamides with potentials antagonistic activities of the N-methyl-D-aspartate in the central nervous system. While the …
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Exzitotoxizität im ZNS bei Mausmutanten mit veränderten Glutamatrezeptoren
… receptor subtypes in principal neurons, NR2A and NR2B has remained enigmatic. This issue was investigated in cultured cortical neurons prepared from wild-type and gene-targeted mice expressing NR2A or NR2B with altered signalling characteristics. Excitotoxicity experiments including …
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Regulation of Excitatory Neurotransmission, Synaptic Plasticity, and Learning by Cyclin-Dependent Kinase 5
… currents and elevated levels of the NR2B N-methyl-D-aspartate receptor subunit. The enhancement in synaptic plasticity was directly attributed to the increased current through NR2B-containing receptors. NR2B levels were elevated in Cyclin-dependent kinase 5 knockout mice due to an …
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Effects of Ifenprodil on the Gating or NR1/2B NMDA Receptors
… activity. Ifenprodil binds to the ATD of NR1/NR2B receptors inhibiting the receptors. To delineate the effects of ifenprodil on NR1/NR2B receptor gating, we recorded steady state currents from cell attached and excised outside out patches at pH7.9. NR1/NR2B receptors were found to exhibit …
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MECHANISMS OF NEUROPROTECTION IN SCN2.2 CELLS
… manner; specifically via the NMDAR 2B (NR2B) subunit. Glu treatment increased expression of NR2B, phosphorylated NR2B and NR1 proteins and decreased NR2A and NR2D mRNA in the GT1-7 cells. Glu-treated SCN2.2 cells showed decreased NR2B, phosphorylated NR2B, increased NR2C proteins and …
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An analysis of morphological changes in visual cortical neurons after knocking down scaffolding proteins of glutamate receptors
… from predominance of NMDA receptors rich in NR2B subunits to that of NMDA receptors rich in NR2A subunits. Normally, eye opening causes PSD-95 levels to increase at synapses and its interactions with NR2A to increase while its interactions with NR2B decrease. In order to identify the exact …
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The induction of long-term potentiation attenuates kainic acid-induced excitotoxicity
… NMDARs are essential for LTP induction whereas NR2B-containing NMDARs are crucial for the production of LTD in vitro, and the results of this study support these findings in the anaesthetized rat. Furthermore, using the kainic acid (KA) model of neurotoxicity, this research has explored the …
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Effects of Neuronal Nogo-A on Properties of Excitatory Synapses of the Sensorimotor Cortex
… Neuroligin-1, NMDA receptor subunits NR2A and NR2B, and PSD-95. We found that mRNA of Neuroligin-1 and NR2B was substantially reduced, with no changes to NR2A or PSD-95 expression. These results suggest that neuronal Nogo-A may act to maintain elements of the neocortical excitatory synapse …
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NMDAR-PSD95-nNOS Axis-Mediated Molecular Mechanisms in the Basolateral Amygdala Underlying Fear Consolidation
… currents, increased synaptosomal NMDAR NR2B subunit expression, and phosphorylation of synaptosomal AMPAR GluR1 and NMDAR NR2B subunits in the BLA. Importantly, we showed that pharmacological and genetic blockade of nNOS activity inhibits all of these glutamatergic synaptic plasticity …
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Involvement of the NMDA Receptor in Moderate Ethanol Preconditioning-Dependent Neuroprotection From Amyloid-Beta in Vitro
… neurotoxic Aβ. Specifically, NMDAR subunits NR1, NR2B and NR2C were elevated by day 2 of MEP treatment and remained increased through day 6. MEP also increased post-synaptic scaffolding protein PSD-95 and the phosphorylation of tyrosine 1472 of NR2B-- both of which are documented markers for …
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The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse
… larger NMDA EPSCs with higher sensitivity to the NR2B subunit-specific antagonist ifenprodil in P14-17 synapses of CaV1.3-/- deaf compared to wt mice. These results suggest that auditory activity is required for the adjustment of synaptic strength as well as for the down regulation of synaptic …
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Evaluation of the Role of Astrocyte Glutamate Transport and of Synaptic NMDA Receptor Subtype Representation in the Pathogenesis of PTSD
… NMDA receptor subtype inhibitor), or Ro-25 (a NR2B NMDA receptor subtype inhibitor). P-CREB was measured in the tissues treated with GCs to determine if GCs exert greater inhibition of long-term memory in the PFC (a region reported to express high NR2A) than in the amygdala (a region reported …
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Synaptic and extrasynaptic NMDA receptors in hippocampal neurons: regulation of nuclear shape and cell fate
… Conantokin-G, a peptide antagonist against the NR2B subunit of NMDA receptors, to beads of a specific size. The peptide coupled to beads should allow blockade of extrasynaptic NMDA receptors and thereby block cell death pathways, leaving synaptic NMDA receptors unaffected.
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The role of glutamate transporters and the scaffolding protein IQGAP1 in the regulation of AMPA receptor trafficking and turnover
… activation of parasynaptically localized NR2B-containing NMDA receptors (NMDARs) is required for AMPAR degradation, suggesting glutamate spillover from the synaptic cleft occurs during EAAT inhibition. Interestingly, I found that the neuronal, but not the glial glutamate transporters are …
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Potential for change: Characterizing synaptic plasticity following visual discrimination learning in adult rats.
… the primary visual cortex (V1) was blocked by an NR2B antagonist, suggesting that training resulted in changes in NMDA receptor expression or functioning. Next, the effectiveness of LTD stimulation protocols to elicit synaptic depression under in vivo conditions were assessed. Of several …
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Neuroadaptive Changes in the Mesocortical Glutamatergic System during Nicotine Self-administration and after Extinction in Rats
… (mPFC), NMDA receptor subunit 2A (NR2A) and NR2B were increased by 67% and 83%, respectively. In the ventral tegmental area (VTA), glutamate receptor subunit 2/3 (GluR2/3) was increased by 34%. These findings suggest the glutamate neurotransmission between mPFC and VTA may be enhanced during …
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The Manipulation Of Apical Dendritic Plasticity And The Consequences For The Effects of Chronic Stress
… subunits. PSA removal prevented stress-induced NR2B decreases and NPY increases. Although chronic immobilization stress was not enough to cause long-term damage, a future experiment presenting a insult to the hippocampus following chronic stress in animals with PSANCAM removal could show just …
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When to learn and when to forget : NMDA normalization in hippocampal neurons-- activity-dependent, temporal and spatial properties.
… voltage-dependent Mg2+ block of NMDA receptors. NR2B-containing NMDARs are up-regulated by this treatment, and this is found to be an important contributor to plasticity enhancement. Thus, the quality, but not the quantity, of activity is the important parameter to manipulate to obtain a …
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Requirement for AMPA receptor endocytosis and long-term depression in ocular dominance plasticity
… lower via a decrease in the ratio of NR2A to NR2B N-methyl-d-aspartate receptor (NMDAR) subunits. Facilitated by the decreased modification threshold, open-eye responses are strengthened via homosynaptic longterm potentiation (LTP). One established LTD mechanism is a loss of sensitivity to the …
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