Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"NR2A"”.
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Domains of the NR2A and NR2B subunits involved in NMDA receptor current modulation by PKC.
Domains of the NR2A and NR2B subunits involved in NMDA receptor current modulation by PKC.
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Exzitotoxizität im ZNS bei Mausmutanten mit veränderten Glutamatrezeptoren
… NMDA receptor subtypes in principal neurons, NR2A and NR2B has remained enigmatic. This issue was investigated in cultured cortical neurons prepared from wild-type and gene-targeted mice expressing NR2A or NR2B with altered signalling characteristics. Excitotoxicity experiments including …
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The induction of long-term potentiation attenuates kainic acid-induced excitotoxicity
… fate. Research in our lab has indicated that NR2A-containing NMDARs are essential for LTP induction whereas NR2B-containing NMDARs are crucial for the production of LTD in vitro, and the results of this study support these findings in the anaesthetized rat. Furthermore, using the kainic acid …
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An analysis of morphological changes in visual cortical neurons after knocking down scaffolding proteins of glutamate receptors
… NR2B subunits to that of NMDA receptors rich in NR2A subunits. Normally, eye opening causes PSD-95 levels to increase at synapses and its interactions with NR2A to increase while its interactions with NR2B decrease. In order to identify the exact roles of the two MAGUKs, this study examined …
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Functional role of NMDA receptor subunit composition in metaplasticity
… in NMDAR subunit composition by focusing on the NR2A subunit of the NMDA receptor in visual cortex. We provide evidence for the functional significance of the NR2A subunit in metaplastic changes both in synaptic platicity elicited in vitro and in naturally-occurring platicity in vivo. We also …
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Coordination between presynaptic and postsynaptic properties measured at single terminals in hippocampal cultures
… the functional addition of GluR2 and NR2A subunits to AMPA and NMDA receptors, respectively, as well as the absolute strength of AMPA- and NMDA-mediated currents. I examined both spontaneous quantal events and local responses using glutamate iontophoresis at putative single-synaptic …
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Effects of Neuronal Nogo-A on Properties of Excitatory Synapses of the Sensorimotor Cortex
… including Neuroligin-1, NMDA receptor subunits NR2A and NR2B, and PSD-95. We found that mRNA of Neuroligin-1 and NR2B was substantially reduced, with no changes to NR2A or PSD-95 expression. These results suggest that neuronal Nogo-A may act to maintain elements of the neocortical excitatory …
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Regional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during development
… sub-chronic PCP-induced up-regulation of NR1 and NR2A. Finally, we were able to correlate changes in NMDA receptor subunits to the behavioral effects of PCP in this animal model of schizophrenia.
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Actions of alpha-chimaerins in mechanisms relevant to dendritic spine formation and neurodegeneration
… Src kinase Fyn, and via its C1 domain with the NR2A subunit of the NMDA receptor. Further experiments explored a1-chimaerin effects on EphA4 and NMDA receptor cell surface expression, as well as binding to other putative partners – including the adaptor protein p35 and the polarity protein PAR6. …
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Effects of Ifenprodil on the Gating or NR1/2B NMDA Receptors
… similar to those previously reported for NR1/NR2A receptors. In order to further understand actions of ifenprodil we fitted the single channel data to previously proposed models for NMDA receptor gating. Log likelihood criteria suggested that a cyclic model containing two uncoupled open states …
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MECHANISMS OF NEUROPROTECTION IN SCN2.2 CELLS
… NR2B and NR1 proteins and decreased NR2A and NR2D mRNA in the GT1-7 cells. Glu-treated SCN2.2 cells showed decreased NR2B, phosphorylated NR2B, increased NR2C proteins and increased NR2A and NR2D mRNA levels. These data are consistent with varied NMDAR responses to Glu in GT1-7 vs. …
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Evaluation of the Role of Astrocyte Glutamate Transport and of Synaptic NMDA Receptor Subtype Representation in the Pathogenesis of PTSD
… in the presence of glucocorticoids, NVP-AA077 (a NR2A NMDA receptor subtype inhibitor), or Ro-25 (a NR2B NMDA receptor subtype inhibitor). P-CREB was measured in the tissues treated with GCs to determine if GCs exert greater inhibition of long-term memory in the PFC (a region reported to express …
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Effects of perinatal phencyclidine treatment on neuronal viability, N-methyl-D-aspartate receptor regulation and schizophrenic-like behaviors
… synaptic or extrasynaptic localization of NMDA NR2A and 2B receptors may dictate function and neuronal susceptibility to cell death. Finally, the purpose of specific aim 4 is to demonstrate that neurotoxicity underlies the development of behaviors which model several aspects of schizophrenia, …
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Neuroadaptive Changes in the Mesocortical Glutamatergic System during Nicotine Self-administration and after Extinction in Rats
… cortex (mPFC), NMDA receptor subunit 2A (NR2A) and NR2B were increased by 67% and 83%, respectively. In the ventral tegmental area (VTA), glutamate receptor subunit 2/3 (GluR2/3) was increased by 34%. These findings suggest the glutamate neurotransmission between mPFC and VTA may be …
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Requirement for AMPA receptor endocytosis and long-term depression in ocular dominance plasticity
… becomes lower via a decrease in the ratio of NR2A to NR2B N-methyl-d-aspartate receptor (NMDAR) subunits. Facilitated by the decreased modification threshold, open-eye responses are strengthened via homosynaptic longterm potentiation (LTP). One established LTD mechanism is a loss of …
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The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… phosphorylation status of the NMDA receptor NR2A subunit following OGD/R, ultimately resulting in an enhancement of NMDA receptor mediated cell death. In-situ studies using acute organotypical hippocampal slices prepared from adult male rats were performed to examine the role of the …
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The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… phosphorylation status of the NMDA receptor NR2A subunit following OGD/R, ultimately resulting in an enhancement of NMDA receptor mediated cell death. In-situ studies using acute organotypical hippocampal slices prepared from adult male rats were performed to examine the role of the …
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Mechanisms of ocular dominance plasticity in the juvenile and adult mouse visual cortex
… mouse model, I find that a reduction in the NR2A/B subunit ratio of the N-methyl-d-aspartate (NMDA) receptor during MD alters the qualities of OD plasticity by impairing weakening of deprived-eye inputs and enhancing strengthening of open-eye inputs. These findings suggest that NMDAR subunit …
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Συμβολή του γλουταμινεργικού υποδοχέα Ν-μεθυλο-D-ασπαρτικού οξέος στην πλαστικότητα του αναπτυσσόμενου οπτικού συστήματος
… μεταβολή των επιπέδων έκφρασης των υπομονάδων NR2A και NR2B του υποδοχέα NMDA κατά την ανάπτυξη των επίμυων στο σκοτάδι (οπτική αποστέρηση) στον αμφιβληστροειδή. Δεύτερος στόχος να μελετήσουμε την επίδραση του οπτικής αποστέρησης στην φωσφορυλίωση της υπομονάδας ΝR2B στον αμφιβληστροειδή και …