Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"NPY"”.
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Hormone Regulation of NPY Neuron Activity in the Arcuate Nucleus of the Hypothalamus
Neuropeptide Y (NPY)-expressing neurons in the arcuate nucleus of the hypothalamus are part of a neuroendocrine feedback loop that regulates feeding behavior and glucose homeostasis. NPY neurons sense peripheral signals of energy stores, including the hormones leptin, insulin, and ghrelin, and …
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Neuropeptides and neurotrophic factors in epilepsy: seizure suppressant actions of VEGF, NPY and galanin
… growth factor (VEGF), neuropeptide Y (NPY), and galanin. To study these molecules, we have used different animal models of epilepsy and investigated the effect on epileptic seizures by enhancing the expression of these endogenously occurring proteins and/or their receptors in the brain …
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Changes in NPY staining in the arcuate nucleus during and after food restriction in lactating rats
… effects of food restriction on Neuropeptide Y (NPY) staining in the arcuate nucleus of lactating rats to evaluate a role for NPY in the maintenance of lactational diestrus in food restricted rats. NPY staining was compared on days 15, 20 and 25 of lactation between animals fed ad libitum (AL) …
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Modulation of Neutrophil Functions by Neurotransmitters Implicated in Stress
… while plasma levels of neuropeptide Y (NPY) are significantly increased. Sympathetic nerve fibers with NPY have been found to innervate immune organs. It was hypothesized that NPY might be a mediator in immune modulation in people under chronic stress. Human neutrophils were used as a …
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Effects of Neuropeptide Y on Adipocyte Metabolism
Recently, we have shown that neuropeptide Y (NPY) is produced and upregulated in visceral adipose tissue of an early-life programmed rat model of central obesity. Moreover, we have demonstrated that NPY contributes to the pathogenesis of obesity. However, the role of NPY in regulating adipocyte …
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Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides
… therapeutic interventions. The neuropeptide Y (NPY) may represent one such target, as it plays a key role in controlling excitability in the hippocampus by suppressing glutamatergic transmission. If manipulated, the NPY system may be capable of restoring the imbalance between excitation and …
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The Role of Neuropeptide Y Y1R in Skeletal Muscle Lipid Metabolism
… found that the neuropeptide Y Y1 receptor (NPY Y1R) mRNA expression is elevated in skeletal muscle of obese humans (Hulver, unpublished). The goal of this research is to study the role of the NPY Y1R in skeletal muscle lipid metabolism. Rat L6, mouse C2C12, and human primary myotubes were …
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Neuropeptid Y- und Prionprotein- spezifische Aptamere
… charakterisiert werden. Das Neuropeptid Y (NPY), bestehend aus 36 Aminosäuren, gehört zur Familie der pankreatischen Polypeptide und ist bei der Steuerung einer Vielzahl physiologischer und pathophysiologischer Prozesse von Bedeutung. Es wird angenommen, daß durch selektive Bindung …
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Investigating the Role of Neuropeptide Y in the Ventral Hippocampus in Regulating Rats’ Elevated Plus-Maze and Shock-Probe Burying Behaviours
Neuropeptide Y (NPY) has recently gained interest as a potential regulator of anxiety-like behaviours. However, its anxiety-associated effects in the ventral hippocampus are not well known, even though this structure is also heavily implicated in anxiety regulation. The goal of this thesis was to …
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Altersabhängige renovaskuläre Effekte sympathischer Kotransmitter im spontan hypertensiven Rattenmodell
… bei hoher sympathischer Aktivität durch NPY potenziert wurden. Da eine Überaktivität des sympathischen Nervensystems bei der Entstehung der arteriellen Hypertonie eine entscheidende Rolle spielt, sollte in dieser Arbeit untersucht werden, ob die bei spontan hypertensiven Ratten durch ATP …
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Dietary macronutrient composition and exogenous neuropeptide Y affect feed intake in brioler chicks
… appetite regulation. Neuropeptide Y (NPY), a 36 amino acid peptide, plays a major role in regulating the hunger signals from the brain. In all vertebrates studied, it is a strong orexigenic neurotransmitter located throughout multiple nuclei of the hypothalamus. Peripheral hormones …
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Regulation of Neuropeptide Y, Vasoactive Intestinal Polypeptide, and Their Receptors in Trigeminal Ganglion Neurons and Glia in Response to Adjuvant-Induced Inflammation
… and pain transmission. Neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), and their receptors have been implicated in the underlying pathology of temporomandibular joint disorders. The goal of this study was to investigate activation of NPY, VIP, and their receptors in a …
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Effects of dietary macronutrient composition and exogenous neuropeptide Y on adipose tissue development in broiler chicks
… macronutrient composition on neuropeptide Y (NPY)-mediated regulation of adipose tissue physiology in broiler chickens during the early post-hatch period. A high-carbohydrate (HC), high-fat (HF) or high-protein (HP) diet was fed to broiler chicks in all experiments and various facets of …
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Role of appetite-regulating peptides in adipose physiology in broiler chicks
… known as the "brain-fat axis". Neuropeptide Y (NPY) is orexigenic and promotes adipogenesis in both birds and mammals, although mechanisms in adipose tissue are unclear. The first objective was thus to evaluate effects of NPY on chick preadipocyte proliferation and differentiation. Preadipocytes …
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Aspects of autoantibody epitopes in type 1 diabetes
… for insulin, GAD65 or IA-2. Neuropeptide Y (NPY) was reported as a minor autoantigen in T1D. This neurotransmitter has a SNP, rs16139, at aa position 7 in the NPY gene. The major allele is coding for leucine (L), and the minor for proline (P). The latter has been associated with impaired …
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Metabolic signalling and neuroendocrine stress responses in pregnancy
… hypoglycaemia (IIH) and the orexigenic peptides NPY, orexin and ghrelin was investigated with particular focus on the mechanisms involved in restraining these responses during late pregnancy. IIH increased ACTH secretion similarly in both virgin and pregnant rats. Unlike most stressors IIH did …
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Neurochemical Changes Following Stroke: Role In Neuroprotection And Cardiac Susceptibility
… the immunoreactivity for TH and neuropeptide Y (NPY) increased in the insular cortex (IC) within the peri-infarct zone. NPY also increased ipsilaterally in the basolateral nucleus of the amygdala, whereas leucine-enkephalin, dynorphin and neurotensin increased ipsilaterally in the central nucleus …
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Charakterisierung autonomer Veränderungen mittels neurohumoraler Parameter bei essentieller Hypertonie
… mittels Bestimmung von Plasmakatecholaminen , NPY und Angiotensin II, während standardisierter Fahrradergometrie und orthostatischem Provokationsmanöver im Vergleich untersucht. <br>In Ruhe waren Noradrenalin, Insulin und Renin signifikant höher (p<0,05) bei übergewichtigen Hypertonikern als …
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Endogenous modulators of hyperexcitability in epilepsy: electrophysiological and optogenetic delineation of neuropeptide Y mechanisms in interneurons
… intervention. Among these, neuropeptide Y (NPY ) seems to be a particularly promising target, as it plays an important role in controlling neuronal excitability in different brain areas, including the hippocampus. Indeed, overexpression of NPY via gene therapy approaches in animal models of …
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