Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"NPPB"”.
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CFTR klórgöng í ristilþekju hænsnfugla (Gallus gallus)
… fyllt með Krebs fosfat búffer. Efnunum glúkósa, NPPB (klórgangahindi) og forskolin (CFTR örvari) bætt út í baðið í mismunandi röð til að kanna virkni klórganganna. Niðurstöður: Glúkósi hafði engin marktæk áhrif á jónaflutning yfir ristilþekjuna. NPPB hafði marktæk neikvæð áhrif á jónaflutning …
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TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils
… and 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB). Protein expression of the chloride channel (CLC) family of chloride channels, PKC isozymes, and Smad transcription factors was determined using western blot, and mRNA expression of CLC was examined using RT-PCR. Chloride channel activity was …
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Chloride Channels in Normal Human Blood Monocytes and a Macrophage-like Cell Line
… Volume-sensitive chloride channel blockers, NPPB and IAA94, attenuated Cl' currents, as well as inhibited monocyte chemotaxis with similar sensitivity, as measured in a Boyden chemotactic chamber. NPPB, but not IAA94, increased cell volume (as measured by shape change) and decreased …
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New gating states of Cystic Fibrosis transmembrane conductance regulator discovered via studying pathogenic mutations, pharmacological reagents and ATP analogs.
… Second, by studying the gating mechanism of NPPB on CFTR, we further confirmed the existence of these two states. Third, an ATP analog, 2-deoxy-ATP was used to explore the gating pathway provided by these two new states. This study not only bears the significance of the fundamental function …
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Mechanisms of ion channel activation in primary cultured and clonal cell lines
… inhibited by the chloride channel inhibitors NPPB and DIDS but resistant to DPC. A Cl- conductance with similar characteristics was found to be present in mouse primary cultured calvarial osteoblasts. The volume-sensitive Cl- current in ROS 17/2.8 cells was inhibited by arachidonic acid in two …
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Nongenomic Effects of Estrogens on Epithelial Chloride Secretion.
… by the chloride channel blockers DIDS and NPPB but is abolished by the PKA inhibitor H89, suggesting that 17β-E2 potentiation depends on the activity of CFTR but not other types of apical membrane chloride channels. 17β-E2 does not increase the activity of calcium-activated potassium …
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Evaluation of Anion Transporters as Potential Target Sites for Insect and Nematode Control: Toxicological, Electrophysiological, and Molecular Studies
… acid), 9-AC (anthracene-9-carboxylic acid), NPPB (5-nitro-2-(3-phenylpropylamino) benzoic acid), and IAA-94 (indanyloxy acetic acid) were selected to evaluate ATs as potential target sites for insect and nematode control. All the AT blockers showed slowly developing toxicity against …
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ADP regulation of insulin secretion and beta-cell apoptosis
… blocker nifedipine, VRAC-channel inhibitor NPPB, pannexin-1 blocker carbenoxolone, or silencing of MDR1 all resulted in a substantial decrease in high glucose/palmitate induced ATP release. Furthermore, high glucose and palmitate inhibited cAMP production, reduced cell proliferation in …
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Nerve growth factor regulates Na+ transport in human airway epithelial cells
… There were no differences in response to NPPB or ouabain, indicating NGF did not have an affect on Cl- transport or the Na+/K+-ATPase. To investigate if the trkA receptor was responsible for mediating the NGF-induced reduction in Na+ transport, the non-specific tyrosine kinase inhibitor, …
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A STICKY SITUATION: ESSENTIAL ROLES OF ADHESION G PROTEIN COUPLED RECEPTORS ADGRF5 AND ADGRG1 IN CARDIAC HOMEOSTASIS AND FAILURE
… coincided with enhanced expression of Nppa and Nppb gene expression. Conversely, by directing overexpression of ADGRF5-CTF to myocytes specifically via AAV9-cTnT-ADGRF5-CTF-Flag vs LacZ delivery, injected retro-orbitally 3-weeks post TAC-induction, revealed that ADGRF5 prevented the onset of …