Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"NPM1c"”.
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THE METHIONINE CYCLE AS A NOVEL THERAPEUTIC TARGET IN NPM1C DRIVEN ACUTE MYELOID LEUKEMIA
… of cases). Though the role of the NPM1 mutation (NPM1c) in the maintenance of the leukemic state is well characterized, little is known about underlying molecular mechanisms of oncogenesis. Most notably, the mutation causes an aberrant cytoplasmic localization of the protein, which is otherwise a …
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Molecular Characterisation and Therapeutic Targeting of NPM1-mutant Acute Myeloid Leukaemia
… the molecular consequences of NPM1 mutations (NPM1c) are incompletely understood and this hinders progress in designing effective therapeutic strategies. This thesis describes my work to characterise NPM1-mutant cells at the molecular level using different omics approaches with the key goal of …
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Identification and characterisation of Pu.1-driven gene regulatory complexes and networks in Acute Myeloid Leukaemia.
… both mouse and human cell-lines and within the Npm1c/Flt3-ITD primary mouse model, making comparisons between leukaemia and appropriate normal control populations at every layer. Specifically, we have compared and contrasted; Multiomic data (sc + snRNAseq & snATACseq), integrative Bioinformatic …
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Identification of novel genetic vulnerabilities and therapeutic targets in acute myeloid leukaemia using CRISPR dropout screens
… such screen in AML cells driven by mutant Npm1 (NPM1c) and Flt3-ITD, the commonest two-mutation combination in human AML. Downstream analysis of the results revealed the excellent potential of this type of screen and enabled me to investigate the molecular effects on mutant Npm1, which are …
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Quantitative Analyses of Normal and Precancerous Somatic Evolution in Human Tissues
… haematopoietic stem cells across 8 DNMT3Amut/NPM1c acute myeloid leukemia (AML) patients to reveal the patterns of driver mutation co-occurrence in ostensibly healthy stem cells. We constructed phylogenetic trees using preleukemic HSCs for all eight patients and assigned cells to tree nodes …