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Showing 1 to 1 of 1 for “"NPM1, AML, p53, NMR, apoptosis, CNS"”.
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Structural characterization of the C-terminal domain of human nucleophosmin, NPM1
<P>NPM1 IS A MULTIFUNCTIONAL PHOSPHOPROTEIN WHICH SHUTTLES BETWEEN NUCLEUS AND CYTOPLASM. WHEN NPM1 INTERACTS WITH P53, A MUTATION IN ITS C-TERMINUS LEADS TO SEQUESTRATION OF P53 INTO CYTOPLASM, PREVENTING IT FROM GOING INTO THE NUCLEUS. WE HAVE CARRIED OUT STRUCTURAL STUDIES ON THE 53 RESIDUE …