Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 80 for “"NPCs"”.
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Modelling Human Behaviour for Believable NPCs
… traditional development techniques to develop NPCs indistinguishable from human players.<br/><br/>NPCs have become an essential aspect of a video game; they are used to create an immersive and vibrant environment, and depending on their purpose, can significantly impact how the game is …
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Intracellular signaling cascades in the dopaminergic specification of fetal mesencephalic neural progenitor cells.
Neural stem (progenitor) cells (NPCs) from fetal tissue are an ideal transplantable cell source. They divide rapidly, are able to generate cells of all three neural lineages and do not divide uncontrolled once transplanted into a host organism. To obtain large quantities of cells for …
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Structure and Dynamic Studies of the Nuclear Pore Complex at the Single-Molecule Level
Nuclear pore complexes (NPCs) are large macromolecular structures forming the only known direct route across the double bilayer membrane of the nuclear envelope. The NPC structure has been extensively explored in an effort to elucidate the mechanisms by which they control transport. Many of these …
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Virtual Reality RPG Spoken Dialog System
In computer games, interaction with NPCs have not changed much over time. In Virtual Reality the old ways of getting quest and having conversation with NPCs are not sufficient anymore. The near presence of the NPC gives the player the urge to want to communicate in a more natural way, verbally. In …
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Generating narrative through intelligent agents in digital games
… generates a population of non-player characters (NPCs) with which the player will interact and assigns the NPCs a set of goals to carry out. Varying the set of NPCs and their objectives will create a different narrative experience for the player when the game is replayed. Although the NPC …
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Investigating the role of cell-autonomous ROS status in the regulation of hippocampal neural precursor cells in adult mice
… continued recruitment of neural precursor cells (NPCs) into active cell cycle and their progressive transition into post-mitotic granule cells. These adult born neurons integrate into the existing circuitry and confer structural plasticity, which aids in key hippocampal functions. For sustained …
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Purification of Human Immunodeficiency Virus Type 1 Preintegration Complexes by Velocity Gradient Centrifugation.
… mediated by two large nucleoprotein complexes (NPCs), the reverse transcription complex (RTC) and the preintegration complex (PIC). These complexes are responsible for the conversion of viral RNA into viral DNA, transport through the cytoplasm, import into the nucleus, and the subsequent …
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Safety of Essential Surgery Performed by Non-Physicians in Low and Middle Income Countries
… Some countries train non-physician clinicians (NPCs) in surgery to help solve this problem. The World Health Organization recommends this practice in some cases, although data on its safety is limited. HYPOTHESIS: Complication rates of NPCs and physicians practicing essential surgery in LMICs …
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Merlin Regulation of Mouse Spinal Cord Neural Precursor Cell Function
… multipotent neuroglial progenitor (stem) cells (NPCs) within the spinal cord. Whereas many spinal ependymomas exhibit indolent behavior, the only treatment option for clinically-symptomatic tumors is surgery. Neurofibromatosis type 2 (NF2) is an autosomal dominant inherited cancer predisposition …
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Proteomic, Bioinformatic and Functional Characterization of the Nuclear Pore Complex of the African Trypanosome
… assemblages known as nuclear pore complexes (NPCs). Yeast and vertebrate NPCs are comprised of about 30 proteins, termed nucleoporins (Nups), which are present in multiple copies. The origins and evolution of the nucleus and NPC are not yet clear, although it seems likely that the nucleus …
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An in Vitro Microenvironment for Nucleus Pulposus Regeneration
… to begin. Initially, nucleus pulposus cells (NPCs) display altered morphology and function, along with increased rates of cellular senescence and apoptosis. Though no widely accepted treatment exists, autologous NP implantation techniques have shown promise. However, the process is flawed as a …
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The role of the immune system in Parkinson’s Disease: from neuropathology to treatment.
… for PD. Several groups have shown that hESC-NPCs can generate mature DAn when grafted into rodent models of PD - providing targeted physiological dopamine replacement and improving motor function. hESCs offer a better source of cells than previously used foetal ventral midbrain (fVM) tissue, …
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Stem cell based therapy of malignant brain tumors
… rat SVZ-derived neural precursor cells (NPCs) and rat multipotent mesenchymal stroma cells (MSCs) into gliomas. Intratumorally implanted NPCs and MSCs migrated specifically within gliomas and largely avoided normal brain tissue. Importantly, implanted NPCs and MSCs did not proliferate …
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Sox2 co-occupies distal enhancer elements with cell-type-specific POU factors to specify cell identity in embryonic stem cells and neural precursor cells
… (ESCs) and multipotent neural progenitor cells (NPCs), but what common or distinct roles Sox2 may play in these cell types not fully understood. Further, the molecular mechanisms by which Sox2 can specify two distinct cell identities are as of yet unclear. This thesis is aimed at answering these …
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Analysis and functional characterization in embryonic mouse neocortex of a set of human-specific genes expressed in neural progenitor cells of fetal human neocortex
… sich vorzugsweise in neuronalen Vorläuferzellen (NPCs) des menschlichen fetalen Neokortexes nachweisen lässt, identifiziert werden (Florio et al., 2018). Drei davon (FAM72B, C und D) sind vor 3,4 – 1 Millionen Jahren im menschlichen Genom durch Genduplikationen entstanden und gehören zur Family of …
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The Role of Transcription Factors in Regulating Adult Neurogenesis after Excitotoxic Brain Injury
… zone (SVZ)-derived neural progenitor cells (NPCs), and their response to injury was investigated. Expression of the transcription factors Mash1, Dlx2, Pax6 and Olig2 in transitamplifying- precursor cells (TAPs) and neuroblasts was examined following quinolinic acid (QA) lesioning of the adult …
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Discrete 3D Model of Molecular Diffusion Through the Nuclear Pore Complex
Nuclear pore complexes (NPCs) are passageways that exist within the nuclear envelope (NE) of a eukaryotic cell. Molecular cargo travel through the passageways to either import to the nucleus or export to the cytoplasm of the cell. Efficient export of certain cargo is necessary for maintained health …
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Optimising Agent Behaviours and Game Parameters to Meet Designer’s Objectives
… and game testers. Automatic optimisation of NPCs to designer’s objective will increase the speed of each iteration, and reduce the overall production time. Previous attempts used entropy evaluation metrics which are difficult to translate the terms to the optimising game and a slight …
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Lower body mechanics of golf swing and its association with maximum clubhead speed in skilled golfers
… analysis to normalized peak clubhead speed (NPCS). Among OA parameters, only the pelvis right lateral tilted position(r = .510, .501, and .522 for driver, 5-iron, and pitching wedge, respectively)and the pelvis right tilting motion (r = .450, .409, and .493 for driver, 5-iron, and pitching …
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An injectable, biomaterial-based therapy to promote endogenous neural progenitor cells in a hemorrhagic stroke lesion
… nestin-positive neural progenitor cells (NPCs) in the lesion. In a well-validated intracerebral hemorrhagic (ICH) stroke model in rats, NPCs were quantified and compared to ICH-only controls at 2 and 4 weeks post-injection.
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