Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"NOXA"”.
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BIM et NOXA sont des effecteurs de l’apoptose induite par TAF6δ
… HeLa WS a conduit à l’identification de BIM et NOXA comme effecteurs potentiels de cette mort cellulaire. Des tests fonctionnels ont permis de démontrer l’implication de cette voie de l’apoptose et de confirmer le rôle de BIM et NOXA. Nos résultats suggèrent également que ce modèle est …
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Investigating the interdependence of human BH3-only protein Noxa and glutamine in activated CD8+ T cells.
Human Noxa, a BH3-only member of the Bcl-2 family of apoptosis regulators, was shown to have both pro-apoptotic and pro-survival functions in human hematological malignancies. Noxa protein is not expressed in unstimulated or naïve human T cells but is induced in CD8+ T cells upon receptor …
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Sera domates yetiştiriciliğinde 2,4-D, 4-CPA ve Noxa'nın meyve tutumu üzerine etkisi
… sera domates yetiştiriciliğinde 2,4-D, 4-CPA ve NOXA'nm meyve tutumu, verim, meyve şekli ve vegetatif organlara etkilerini belirlemek amacıyla yapılmış tır. Bitkisel materyal olarak Amfora, Dario ve doğal partenokarpik meyve oluşturan Carpy çeşitlerinin kullanıldığı çalışmada, 2,4-D 1.0, 2.5 5.0 …
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Preclinical Development of Therapeutic Strategies Against Triple-Negative and Inflammatory Breast Cancer
… against TNBC and IBC by pro-apoptotic protein NOXA-mediated inhibition of the anti-apoptotic protein MCL1 following inhibition of histone deacetylases (HDAC) in combination with inhibition of the oncogenic MEK pathway. In breast cancer patients, low NOXA/high MCL1 tumor expression is indeed …
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Primary characterization of genes involved in the colony development of the insect pathogenic fungus Metarhizium anisopliae /
… of G protein signaling CAG8 and a NADPH oxidase NoxA homolog are necessary for conidiation and virulence. These genes are candidates for further investigation into the regulatory pathways controlling conidiation to yield insight into promising gene targets for biocontrol strain improvement.
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Loperamide enhances bortezomib-mediated cell death in colon cancer cells
… induced by loperamide plus bortezomib 42 5. Noxa is also critical factor for loperamide plus bortezomib-induced cell death 46 6. Disruption of aggresome formation may be involved in the cell death induced by loperamide and bortezomib 50 7. Combined treatment with loperamide and proteasome …
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Role of Pro-Apoptotic Bcl2-Homology-3 Domain (BH3)-Only Proteins in the Mutant SOD1 Mouse Model of ALS
… for the BH3-only proteins, Bik, Bad, BNip3, Bid, Noxa, Puma, and Hrk/Dp5, demonstrated selective staining of Hrk/Dp5, Bnip3, and Bid in astrocytes of lumbar spinal cord from end stage mutant SOD1 mice. Hrk/Dp5, Bnip3, and Bid were not observed in astrocytes of wild type mouse spinal cords. These …
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Novel proapoptotic p63 isoforms are driven by an endogenous retrovirus in the male germ line of humans and great apes, likely increasing genome stability
… proapoptotische Zielgene wie PUMA und Noxa aktiviert, teilweise mit Mitochondrien assoziiert und die Apoptose von human Zellen verstärkt, wenn es durch aktivierte Caspasen nahe des Carboxylterminus gespalten wird. Eine mögliche Rolle von GTAp63 in der testikulären Tumorigenese ist …
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Therapeutic Vulnerabilities of Venetoclax Resistant Chronic Lymphocytic Leukemia and Novel Treatment Strategies Targeting BCL2/BCL-XL
… binding partner of MCL1, <em>PMAIP1</em>/NOXA, suggesting an altered interactome at relapse. By BH3 profiling, VEN relapsed CLL did not completely lose dependence on BCL2 (BAD sensitivity), yet denoted co-dependence on alternative anti-apoptotic proteins, mainly BCL-XL (XXA1_Y4eK …
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Treatment of gonorrhoeal arthritis by artificial fever
… as a reactive process to the invasion of harmful noxa was later still the view of Welsh and others, and during the last four decades opinion has veered in favour of the view that fever has a beneficent purpose. Consequently the idea of the necessity for the combating of fever as a harmful …
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Rho GTPases in Neuronal Apoptosis and Neurodegeneration
… was associated with induction of the CtBP target Noxa. These data indicate a novel function for CtBPs in regulating survival of primary CGNs.</p> <p>Finally, we examined the involvement of Rho GTPases in regulating the survival of motor neurons derived from embryonic stem cells (ESCs) as selective …
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Approaches for Enhancing Therapeutic Efficacy of a Novel IL-10 Gene Family Member: MDA-7/IL-24
… apoptosis in association with up regulation of NOXA, accumulation of Bim, and activation of Bax and Bak. Treatment with mda-7/IL-24 and BI-97C1 (Sabutoclax) inhibited the growth of PC xenografts and suppressed PC development in an immunocompetent transgenic mouse model of PC. The third chapter …