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Showing 1 to 8 of 8 for “"NONMEM"”.
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Evaluation of bootstrapping as a validation technique for population pharmacokinetic models
… validation method was executed using NONMEM for model estimation and the resulting statistics were used to detect models developed from influence data. The metrics of choice were mean absolute prediction error (MAPE) and mean squared prediction error (MSPE). In phase IV, the impact of …
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Population Pharmacokinetics of Therapeutic Monoclonal Antibodies: Examples and Estimation Method Performance Differences
… mixed effects modeling and the software NONMEM. A total of 912 cetuximab concentrations were available from 143 patients with recurrent and/or metastatic SCCHN enrolled in two phase I/II studies. The PK of cetuximab was best described by a two-compartment model with Michaelis-Menten type …
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The determination and validation of population pharmacokinetic parameters of phenytoin in adult epileptic patients in the Western Cape using nonlinear mixed-effects modelling
… report. The data were analyzed using NONMEM (nonlinear mixed-effects modelling), a computer programme designed for population pharmacokinetic analysis that allows pooling of data from many individuals. The Michaelis-Menten and the parallel Michaelis-Menten and first-order elimination …
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A scoping review on the use of telerehabilitation in physiotherapy in low and middle income countries
… mixed-effects modelling in the software NONMEM®. Results: A two-compartment disposition model with transit absorption best fitted the pharmacokinetic data. Allometry using fat-free mass and weight best scaled disposition parameters for body size for the final model. The typical clearance …
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Preclinical Pharmacology of the MDM2 Antagonist Nutlin-3a
… fit to all pharmacokinetic data using NONMEM. Nutlin-3a exhibited nonlinear binding to murine plasma proteins, with the unbound fraction ranging from 0.7 to 11.8%. Nutlin-3a disposition was characterized by rapid absorption with peak plasma concentrations at approximately 2 h and …
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Beta-lactam antimicrobial dosing optimization in obese patients compared to non-obese patients using population pharmacokinetic/pharmacodynamic approach
… pharmacokinetic parameters were estimated using NONMEM, and the final pharmacokinetic model was built by evaluating the effects of covariates on the pharmacokinetic parameters of piperacillin and tazobactam using the stepwise forward inclusion followed by the backward elimination process. Tested …
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A Nomogram for Valproic Acid and the Effect of Missed Doses
<p>Background. Clinicians are divided on dosing recommendations when a dose is delayed or missed. For a neuropsychiatric agent like valproic acid (VPA), rational dosing recommendations are of particular importance. VPA is subject to therapeutic monitoring using total concentrations. Due to …
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Application of population pharmacokinetic-pharmacodynamic modelling evaluate and optimise aminoglycoside therapy in patients with cystic fibrosis
… analysis was first conducted using the package NONMEM with the FOCE (parametric) algorithm. Aminoglycoside concentration-time profiles were available from 166 patients treated within the Glasgow Cystic Fibrosis Unit and comprised 1075 courses of therapy and 2238 concentration measurements …