Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"NOD2"”.
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Role of NOD2/RIP2 signaling in acute bacterial pneumonia and sepsis
… for the nod-like receptors (NLR) NOD1 and NOD2. Nucleotide oligomerisation domain 2 (NOD2) is an intracellular PRR that is shown to be important for host defense against intracellular bacterial pathogens. However, the role of NOD2 and RIP-2 during Gram-negative bacterial pneumonia and …
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Nod1 and Nod2 in Innate Immune Responses, Adaptive Immunity and Bacterial Infection
… helicase receptor (RLH) families. Nod1 and Nod2 are members of the NLR family of proteins, which are responsible for the recognition of components derived from the bacterial cell wall, more precisely, moieties of peptidoglycan. As such, Nod1 and Nod2 are implicated in the recognition and the …
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Prävalenz der 3020insC Mutation des NOD2/CARD15-Gens bei Patienten mit chronischer Parodontitis
… Zusammenhang zwischen der 3020insC Mutation des NOD2/CARD15-Gens und chronisch marginalen Parodontitiden erbringen. Untersucht wurden 80 Patienten mit chronischer Parodontitis und 122 gesunde Patienten. Ein Zusammenhang konnte nicht nachgewiesen werden.
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Optimization of an Immune Assay to Detect Binding of NOD2 to Staphylococcus Aureus
… such as Nuclear Oligomerization Domain 2 (NOD2), present on the surface of and inside innate immune cells. This study aimed to design and optimize an assay that can be utilized to investigate <em>S. aureus</em> components that contribute to the activation of NOD2 receptors. The assay was …
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Regulating the stabilities of NOD1 and NOD2, two innate immune receptors, with sugars and chaperones
… domain containing proteins 1 and 2 (NOD1 and NOD2), members of the NOD-like receptor family (NLRs). These NLRs recognize different fragments from bacterial cell wall peptidoglycan (PG) using their C-terminal leucine rich repeat (LRR) domains and then signal the body to deploy an immune …
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The Impact of Study Methodology on Studying Genetic and Environmental Risk Factors for the Inflammatory Bowel Diseases
… between genetic and environmental factors. NOD2 and cigarette smoking are two of the most commonly replicated genetic and environmental risk factors, respectively, for Crohn’s disease. Studies examining the interaction between NOD2 and smoking in patients with Crohn’s disease have reached …
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Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn’s Disease
… rs17582416; p=0.0085 and p=0.045 respectively). NOD2 was the first IBD susceptibility gene identified. In order to further define pathways involving NOD2, a yeast two-hybrid screen in our laboratory using NOD2 cDNA as the bait had already identified an interaction between NOD2 and UDP-Nacetyl- …
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Visualization and quantification of autophagy in primary gastrointestinal epithelia cell cultures.
… the autophagy related (Atg) protein Atg16L1, and NOD2 as risk alleles for Crohn’s disease. Atg16L1 is essential for the formation of autophagosomes and autophagosome formation is stimulated following recognition of bacterial cell wall peptide muramyl dipeptide (MDP) by NOD2. Crohn’s disease …
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Genetic and Molecular Analysis of the Rj(7) Gene in Soybean Using Pcr-Based Technologies
… independent of rj7 conferring mutations in the NOD2-4 and NOD3-7 mutants. For molecular genetics, no research work has been done in attempts to investigate molecular biology of rj 7 in the NOD mutants. The purposes of the present studies were to determine if there exists an additional mutant …
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Soybean (Glycine max (L.) Merr.); nodulation mutant characterization: Role of isoflavonoid, nitrate, and abscisic acid in nodulation control
… from selected hypernodulating mutants (NOD1-3, NOD2-4, and NOD3-7), a nonnodulating mutant (NN5), and the Williams parent. There were no significant differences in isoflavonoid concentrations of root extracts among lines when plants were not inoculated, while all mutants had higher isoflavonoid …
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Functional Characterization of the Avian Inflammatory Mediators Nod1, MIF and IL-22
… oligomerization domain protein 1 (Nod1) and Nod2 initiate host innate immune response by recognition of specific bacterial molecules, resulting in the production of pro-inflammatory cytokines, chemokines, and anti-microbial peptides. A candidate sequence of chicken Nod1 (ChNod1) was …
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Genetic determinants of susceptibility and disease behaviour in early onset Inflammatory Bowel Disease in Scottish children
… of the three common mutations within the NOD2/CARD15 gene (R702W, G908R and Leu1007finsC) was analysed in 247 children with IBD. The Leu1007finsC variant was associated with Crohn’s disease by case-control (p = 0.01) and TDT analysis (p = 0.006). Genotype phenotype analysis demonstrated …
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Staphylococcus aureus as a source of antigens stimulating bovine dendritic cells and lymphocytes in vitro
… S. aureus strain to evaluate if α-toxin-mediated NOD2 receptor signaling activates Th1 polarization in response to S. aureus, which revealed that NOD2 mRNA transcription in DC was independent of α-toxin and that the deletion of α-toxin had no effect on the transcription of the cytokine IL-12 or …
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SYNDROMIC HIDRADENITIS SUPPURATIVA: GENOTYPE-PHENOTYPE CORRELATION THROUGH WHOLE-EXOME SEQUENCING IN 10 UNRELATED PATIENTS
… inflammation showed three different variants in NOD2 gene, two variants in OTULIN, and a variant in GJB2, respectively. Three PAPASH and three PASH/SAPHO overlapping patients who had also joint inflammation showed two different variants in NCSTN, one in WDR1 and PSTPIP1, and two variants in …
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Exploring the role of Leucine Rich Repeat Kinase 2 within the innate immune system
… of LRRK2 in TLR4 mediated signalling, as well as NOD2 mediated signalling. Comparison of LPS responses between WT and LRRK2 KO genotype macrophages identified a role of LRRK2 in modulating transcription of a range of chemokines and chemokine receptors. This indicates a specific role of LRRK2 in …
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Nitrogen fixation potential and agronomic evaluation of three hypernodulating mutants of soybean
The three hypernodulating mutants (NOD1-3, NOD2-4, and NOD3-7) of soybean (Glycine max (L.) Merr.) and the parent (Williams) were evaluated for short-term NO$\sb3\sp-$ effect on N$\sb2$ fixation, measured by an acetylene (C$\sb2$H$\sb2$) reduction assay and by the relative ureide abundance …
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Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine
… in an epithelial cell-intrinsic MyD88-dependent, NOD2-independent manner. Utilizing mice deficient in small intestinal epithelial cell autophagy (Atg5∆IEC), I have determined that epithelial cell autophagy is required to limit pathogen dissemination to extraintestinal sites. This study thus shows …
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Novel Functions of ATG16L1 in the Innate Response to Invasive Bacterial Pathogens
… in the inflammatory response driven by NOD1 and NOD2, which are intracellular sensors of bacterial invasion. Secondly, we identified an interaction between complement C3, the central component of the complement cascade, and ATG16L1. This interaction allows for efficient targeting of complement …
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