Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"NOD-like receptors"”.
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Examining the Role of Non-Canonical NOD-like Receptors and Inflammasomes in Inflammation and Disease
The NOD-like Receptors (NLRs) are a family of pattern recognition receptors known to regulate a variety of immune signaling pathways. A substantial portion of NLR research focuses on the pyrin domain-containing NLRP subfamily. The canonical NLRPs are inflammasome-forming proteins responsible for …
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Characterization of pattern recognition receptor responses against materials for cell encapsulation
… may sense alginate via pattern recognition receptors (PRRs), such as toll-like receptors (TLRs) and NOD-like receptors (NLRs). However, which PRRs are involved, how they recognize alginate, and whether alginate material characteristics and compositions can elicit different responses are not …
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On the discovery and biological characterization of porcine β-Defensin 5 (pBD-5)
… inflammatory mediators such as IL-17, toll-like and NOD-like receptors. We synthesized pBD-5 using an orthogonal chemical approach to assess its structural and functional properties. The oxidized form, with correctly folded disulfide bonds, exhibited antimicrobial activity against …
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Characterisation of the lipooligosaccharide biosynthesis gene cluster in campylobacter species
… [Nucleotide binding oligomerisation domain (NOD) like receptors with pyrin domain–containing 3] inflammasome dependent signalling in a human monocytic cell line, THP-1. However, C. jejuni 11168 LOS mutant live cells and its modified LOS with altered lipid A and lack of LOS core …
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Role of NOD2/RIP2 signaling in acute bacterial pneumonia and sepsis
… to bacterial clearance. Pattern recognition receptors (PRRs) play a critical role in the innate immune system. Receptor interacting protein 2 (RIP-2) is an adaptor for the nod-like receptors (NLR) NOD1 and NOD2. Nucleotide oligomerisation domain 2 (NOD2) is an intracellular PRR that is shown …
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Battling Bacteria: Characterizing the NOD-Like Receptor (NLR) Immune Response to <i>Brucella abortus</i> and <i>Borrelia burgdorferi</i> in Host-pathogen Interactions
… diseases. Characterized by Pattern Recognition Receptors (PRRs), which sense conserved molecular motifs known as Pathogen-Associated Molecular Patterns (PAMPs), the innate immune system sets a system of checks and balances to regulate inflammation in host defense. In this dissertation, we focus …
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Elucidating the Role of Pattern Recognition Receptors in Understanding, Treating, and Targeting Cancer
Pattern Recognition Receptors (PRRs) are a group of evolutionarily conserved and germline-encoded cellular receptors of the innate immune system that are responsible for recognizing and responding to the entirety of the pathogens a host encounters. The ingenuity of the innate immune system is that …
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Nod1 and Nod2 in Innate Immune Responses, Adaptive Immunity and Bacterial Infection
… signals can be detected by germ-line encoded receptors has changed the way we study the immune system. Indeed, the characterization of Toll in Drosophila as a sensor of microbial products in 1997 then led to the discovery of a family of Toll Like Receptors (TLRs) in mammals. TLRs are critical …
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Regulating the stabilities of NOD1 and NOD2, two innate immune receptors, with sugars and chaperones
… is composed of a number of pattern recognition receptors (PRRs) that respond to microbe associated molecular patterns (MAMPs) unique to specific microorganisms. Two well characterizes PRRs are nucleotide- binding oligomerization domain containing proteins 1 and 2 (NOD1 and NOD2), members of the …
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Protective or Problematic? Investigating the role of the innate immune receptor NLRX1 as a tumor suppressor or promoter in breast and pancreatic cancer
… signaling proteins called pattern recognition receptors (PRRs) that are responsible for recognizing highly-conserved molecular patterns associated with pathogens or damage to elicit an immune response. However, NLRX1 is a unique PRR in the NOD-like receptor (NLR) family that instead functions …
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Intracellular triggering of inflammation by the extracellular bacterium Pseudomonas aeruginosa
… the innate immune system via germ-line encoded receptors, pathogen recognition receptors (PRRs). These receptors recognise conserved microbial patterns, known as pathogen-associated molecular patterns and molecules which signal danger, danger-associated molecular patterns. PRRs are both membrane …