Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"NOD mouse"”.
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Aspects of T cell development contributing to autoimmunity.
… apoptosis resistance in the non-obese diabetic (NOD) mouse. The role of thymic expression of TGF-β was dissected by using TGF-β type II receptor cre/lox conditional knock out mouse model. By transplanting bone marrow to irradiated recipients we restricted the phenotype to hematopoietic stem …
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Dendritic Cell Regulation of Peripheral Tolerance in Polyclonal T Cell Repertoires
… T cells, thereby preventing autoimmunity in mouse models. We succeeded in inducing tolerance to the myelin oligodendrocyte protein and preventing disease in the experimental autoimmune encephalomyelitis model. However no halt or delay in onset of autoimmune diabetes was observed when insulin …
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CHARACTERIZATION OF CD4+ T CELL-INDUCING EPITOPES OF ISLETSPECIFIC GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT-RELATED PROTEIN (IGRP) THAT PREVENT AUTOIMMUNITY
In the NOD mouse, islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) is an important β cell autoantigen recognized by a majority of cytotoxic CD8+ T cells. This study investigates two IGRP peptides (P3 and P7) which contain MHC class Il-specific CD4+ T cell epitopes. …
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Heat shock protein 90, a potential biomarker for type I diabetes: mechanisms of release from pancreatic beta cells
Heat shock protein (HSP) 90 is a molecular chaperone that regulates diverse cellular processes by facilitating activities of various protein clients. Recent studies have shown serum levels of the alpha cytoplasmic HSP90 isoform are elevated in newly diagnosed type I diabetic patients, thus …
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Effects of 5��-Dihydrotestosterone (DHT) on Mouse Gut Microbiome– A Study of Sex Differences and Hormonal Effects on Gut Microbiome Composition
… in T1D pathogenesis. Furthermore, diabetic mouse models have shown higher incidence of T1D in females compared to males, attributed to the differences in gut microbial community structure. Interestingly, female mouse models elicit male-like protection from T1D when transplanted with the male …
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Characterisation of the anti-inflammatory potential of ES-62 in autoimmune disease
… some other models of inflammation, including the NOD mouse model of Type 1 Diabetes, the Plasmodium chabaudi model of malaria and the Toxoplasma gondii model of toxoplasma, all of which have been linked with Th1-like pathology. However, given the recent reassessment of CIA as a Th17-, rather than …