Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 135 for “"NOD"”.
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Charakterisierung humaner kurz-zeitrepopulierender Blutstammzellen im NOD/SCID-ß2m-/- Xenotransplantationsmodell
… nachgewiesen werden. Mit Hilfe des NOD/SCID-ß2m-/- Maus-Xenotransplantationssystems können zwei verschiedene Klassen humaner STRC quantifiziert werden: myeloisch determinierte (STRC-M) und lymphatisch-myeloisch determinierte STRC (STRC-ML). <br>a)Im Rahmen dieser Arbeit wurde der …
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Examining the Role of Non-Canonical NOD-like Receptors and Inflammasomes in Inflammation and Disease
The NOD-like Receptors (NLRs) are a family of pattern recognition receptors known to regulate a variety of immune signaling pathways. A substantial portion of NLR research focuses on the pyrin domain-containing NLRP subfamily. The canonical NLRPs are inflammasome-forming proteins responsible for …
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The symbiotic interaction of Bradyrhizobium japonicum with bambara groundnut and cowpea and the effects of NOD gene-inducers, daidzein and genistein
… aim of this project was to investigate whether nodulation, and nitrogen concentration of legumes can be increased by providing additional nod geneinducer compounds. Both daidzein and genistein are nod gene-inducers for rhizobia nodulating cowpea, bambara groundnut, soybean and the common bean.
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Battling Bacteria: Characterizing the NOD-Like Receptor (NLR) Immune Response to <i>Brucella abortus</i> and <i>Borrelia burgdorferi</i> in Host-pathogen Interactions
… we focus on one class of PRRs known as the NOD-like Receptors (NLRs) in response to bacterial diseases. This class consists of pro-inflammatory receptors that form a multi-protein complex termed the inflammasome, as well as regulatory NLRs that modulate inflammation. Here, we investigated …
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Untersuchung humaner Stammzellen aus dem adulten Knochenmark und der fetalen Leber
… In Xenotransplantations-experimenten mit NOD/SCID-Mäusen wurde verglichen, ob CD34-transduzierte MSC und nicht transduzierte MSC die Fähigkeit besitzen, einen subletal bestrahlten Organismus zu repopulieren. Bei zwei von insgesamt elf transplantierten Mäusen konnte humanes Engraftment …
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Investigation of the production and isolation of bioactive compounds from cyanobacteria.
… significantly increased during the last decades. Nodularia spumigena is one of the dominant toxic cyanobacteria which produces massive and inherent blooms in brackish water body, the Baltic Sea, particularly in late summer. Nodularia spp. are known to produce nodularins (NOD) and a range of other …
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Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors
… We used the non-obese diabetic mouse (NOD) which is spontaneously developing T1D and have been described to have defects in the T cell maturation. By studying the apoptosis response of NOD lymphocytes (which activates similar cell-cycle checkpoints and apoptosis pathways as during …
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An investigation into the biodegradation of peptide cyanotoxins (microcystins and nodularin) by novel gram-positive bacteria.
… secondary metabolites, microcystins (MC) and nodularin (NOD) have become common contaminants in most aquatic ecosystems over recent years presenting a hazard to animal and human health. Unfortunately, these chemically diverse peptide hepatotoxins remain a challenge to most conventional water …
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EARLY-LIFE EXPOSURES TO SPECIFIC COMMENSAL MICROBES TRAIN THE IMMUNE SYSTEM AND PREVENT TYPE 1 DIABETES
… the early-life microbiome of diabetes-protected NOD/Eα16 mice confers protection from developing type 1 diabetes (T1D) in diabetes-susceptible NOD mice. PedsCom colonization induces weaning-associated peripheral regulatory T cells (pTregs) in the intestines and pancreatic lymph nodes while …
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EMG methods for prosthesis ankle-subtalar free-space control
… named non-negative orthogonal decomposition(NOD). This algorithm aims to replace non-negative matrix factorization(NMF) for muscle motion base extraction. NOD recovers the source signal by finding the borders of the input signal and translating the borders onto the coordinate axis. The …
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Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity
… into streptozotocin (STZ)-treated NOD/SCID mice. However, UCB-derived ALDHhi cells are rare and expansion without the loss of regenerative function is required. We hypothesized that BMS 493, an inverse retinoic acid receptor agonist, will prevent HSPC differentiation of HSPC during …
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The impact of post operative oedema on clinical recovery and its potential causes
… who consistently remained free of oedema (NOD group) Oedema occurred in 40 per cent of the patients observed prospectively and was significantly related to age (odds ratio 1.087 (95 per cent confidence interval (c.i), 1.016 -1.163; P =0.016). The preoperative ratio of Z at 200 kHz to 5 kHz …
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Studies of the effect of cysteine and heme pocket mutations of the nitric oxide dioxygenase and nitrite reductase activities of human Cytoglobin and Androglobin heme domain
… (NiR) and the nitric oxide dioxygenase activity (NOD) working in tandem is a proposed regulatory response which enhances oxygen levels in hypoxic tissues, serving to protect tissues against hypoxia. In hypoxic conditions, NO is generated via the NiR activity, while in normoxic condition NO is …
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Synthese von Oligosacchariden der Zellmembran mit neuartigem Verzweigungsmuster und von lipidhaltigen Signalstoffen pflanzlicher Symbionten
… und Rhizobien die von den Bakterien sekretierten NOD-Faktoren essentiell. Da Dazzo und Hollingsworth N-Palmitoylglucosamin als Minimalstruktur für NOD-Faktoren ansehen, wurden N-Palmitoylglucosamin 70 und andere Mono-saccharid-derivate für biologische Untersuchungen bereitgestellt. Bei …
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Engineering Secreted Proteins for Gene Transfer and DNA Vaccination
… of type I diabetes in both non-obese diabetic (NOD) mice and human patients. After the removal of the N-terminal end of GAD65, the truncated GAD fragment was fused to the C-terminal of the human interleukin-2 leader peptide, and a secreted form of GAD (SGAD55) was obtained. The intramuscular …
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Nicotine and TNF alpha, modulators of T cell signaling-effects on T cell development in fetal thymus organ culture
… diabetes. Our data indicate that thymocytes from NOD FTOC express lower levels of TNF receptors and produce more TNF-alpha compared to non-diabetic C57BL/6 (B6) FTOC. Neutralization of endogenous TNF-alpha in NOD FTOC with a soluble TNF receptor (sTNF R1) rescued insulin production in our in vitro …
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Clinical approaches for understanding the expression levels of pattern recognition receptors in otitis media with effusion
… oligomerization domain-containing proteins (NODs) -1 and -2, all of which are related to bacterial infection in pediatric patients with otitis media with effusion (OME). METHODS: The study sample consisted of 46 pediatric patients with OME, all of whom had ventilation tubes inserted. The …
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Entwurf und Verwendung eines Microarrays zur Untersuchung des Genistein-Stimulons bei Bradyrhizobium japonicum
… einer Reihe von Genen. Durch die Expression der nod-Gene erfolgt eine Synthese von Lipochitooligosacchariden. Diese sogenannten Nodulationsfaktoren rufen wiederum eine Reaktion in der Wirtspflanze hervor. Um die zugrunde liegende Genexpression und deren Regulationsmechanismen zu erforschen, …
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