Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"NO-signaling"”.
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Neuronal Nitric Oxide synthase regulates the expression of EAAT4 and GAD65/67 in the murine cerebellum
… (PFs) that produce high levels of nitric oxide (NO) via neuronal nitric oxide synthase (nNOS). Previous studies demonstrate that nNOS/NO signaling is crucial for PF-PN synaptic transmission. This study sought to examine nNOS/NO signaling regulation of excitatory amino acid transporter 4 (EAAT4) …
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Effects of nNOS Inhibitors on Melanoma-Induced Immunosuppression
<p>The incidence of cutaneous melanoma (CM) rises despite advances in immunotherapy and targeted therapy. Studies have shown that interferon-gamma (IFN-γ), a pro-tumorigenic cytokine in CM, induces the expression of programmed death-ligand 1 (PD-L1), leading to the escape of melanoma cells from …
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Secure computation on untrusted platforms
… on i to obtain P(x), but (P̃, x̃) reveals nothing more than P(x). We devise an efficient garbling scheme, based on the recent notion of indistinguishability obfuscation, in which the RAM running time and space usage of P on x are each the same as for P̃ on ,x̃. No-Signaling Multi-Prover …
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No-Independent Modulation of Soluble Guanylyl Cyclase (Sgc) Activity and Function
… (sGC) plays a key role in the nitric oxide (NO) signaling pathway, where it functions as an NO receptor and generator of a secondary intracellular messenger, cGMP. In addition to NO, investigators have identified a number of proteins that interact with sGC and modulate its function. For …
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Regulation of Endothelial Nitric Oxide Synthase in Pulmonary Myofibroblasts
… failure. At present, the median post-diagnosis lifespan is between three and six years. Myofibroblasts are collagen-secreting cells essential for wound healing, but also implicated in the fibroproliferation and extra cellular matrix deposition commonly seen in IPF. The nitric oxide (NO) …
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Thick Ascending Limb Nitric Oxide Production And Inhibition Of Nkcc2 Activity Are Impaired In Angiotensin Ii-Induced Hypertension
… the filtered sodium chloride load. Nitric oxide (NO) produced by NO synthase type 3 (NOS3) increases cyclic GMP (cGMP) and inhibits THAL transport by reducing Na/K/2Cl cotransporter type 2 (NKCC2) activity. Interestingly, in angiotensin II-induced hypertension, THAL NaCl transport is enhanced. …
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Development of Pharmaceutical Inhibitors Targeting nNOS for Melanoma Treatment
… a well-studied pro-tumorigenic cytokine in melanoma, has been shown to upregulate programmed death‐ligand 1 (PD‐L1) on the melanoma cell. The interaction between PD-L1 and its receptor PD-1 inactivates T-lymphocytes, allowing melanoma cells to escape from immune surveillance. Immune checkpoint …
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Advanced tests of nonlocality with entangled photons
… mechanics can be complete, as it seemingly does not adhere to a natural view of reality: local realism, which is the notion that an event can only be influenced by events in the past lightcone, and can only influence events in the future lightcone. This question sparked a philosophical debate …
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Three Essays in Auctions and Contests
… contests. I establish that there exists no symmetric separating equilibrium under the full revelation rule and find that the non-existence result is very robust. I then characterize a partially efficient separating equilibrium under the partial revelation rule when players' valuations are …
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Network-based IP flow mobility support in 3GPPs evolved packet core
… licensed spectrum, Mobile Network Operators (MNOs) are battling to manage these increased traffic growths. Offloading mobile data traffic to alternative low cost access networks like Wi-Fi has been proposed as a candidate solution to enable MNOs to alleviate congestion from the cellular …
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Mechanisms of Regulation of Proximal Tubule Sodium Transporters in Obesity-Induced Hypertension
… handling in obese hypertensive (OP) and lean normotensive (OR) rats. An acute increase in renal perfusion pressure resulted in a blunted natriuretic response in OP vs. OR rats and indicated that increased sodium reabsorption in the proximal tubule is casual, at least in part, for hypertension …
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Contribution of the Microenvironment in Bone Resident Cancer: the Role of Thrombospondin-1 in Bone and Risk Loci Contributing to Multiple Myeloma
… cytokines to further promote local tumor growth. Notably, cancer cells are unable to remodel bone independently, and require the metabolically active bone cells for this support.</p><p>A specific role for the bone microenvironment in mediating tumor growth was first discussed in 1889 with the …