Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"NNK"”.
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Unraveling the Effects of Nicotine-Derived Nitrosamine Ketone (NNK) on Healthy and Neurodegenerative Brain via Intravital Imaging and Multiscale Ex Vivo Imaging Approaches.
… sclerosis. Nicotine-derived nitrosamine ketone (NNK) is a nicotine metabolite produced within the tobacco plant from combustion and metabolic breakdown of nicotine. Extensive cancer literature has established NNK as an important component of CS resulting in DNA mutation and ability to bind and …
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Inhibitory Effects of Isothiocyanates on the Mutagenicity and Metabolism of Environmental Carcinogens
… 4-(methylnitrosamino)-l-(3-pyridyl)-lbutanone (NNK) and benzo[a]pyrene (BaP) by F344 rat and male Syrian golden hamster liver microsomes were investigated. In addition, the alkyl chain-length effects of BITC and PEITC, together with phenyl isothiocyanate (PITC) and phenylpropyl isothiocyanate …
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Effects of Pycnogenol on Microsomal Cytochrome P450 Activity and Apoptosis
… effects of pycnogenol on the three pathways of NNK metabolism: NNK reduction, N-oxidation and a-hydroxylation. NNK is a lung carcinogen. Lung and liver microsomes from 6 mo and 20 mo old male F344 rats were incubated with <sup>3</sup>H-NNK in the presence of pycnogenol and following intragastric …
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Modulatory Effects of Citrus Flavonoids Towards the Metabolism and Mutagenicity of Environmental Carcinogens
… (HCA’s) and the tobacco-specific nitrosamine NNK generally require internal enzymatic activation. This activation occurs via cytochrome P450 (CYP) enzymes and leads to metabolites that bind to human DNA which may in turn cause mutations which may then in turn lead to carcinogenesis. Certain …
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Biological and functional consequences of polymorphisms in the XPD gene
… exon 10 and Lys751Gln in exon 23. Baseline and NNK-induced chromosomal aberrations (Ca) were assessed by cytogenetic analysis and then P values were calculated as estimates of sub-population differences for increased frequencies of CAs associated with the three XPD polymorphisms. I found …
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Development of A Bayesian Joint Logistic Model to Better Study The Association Between Haplotypes and Disease
… of biomarkers that are present in lung cancer (NNK), and extending this analysis to full GWAS studies.</p>
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Cytochrome P450 enzymes and oxidative stress in tobacco/nicotine mediated HIV pathogenesis
… species (ROS) and/or reactive metabolites, NNK. Based on the fact that CYP pathways play a critical role in smoking mediated cell/organ toxicity, there is a critical need to explore the involvement of CYP pathways in smoking/nicotine-mediated HIV pathogenesis. The present study was based on …
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Biological and Functional Consequences of Single Nucleotide Polymorphisms of the O6-Methylguanine-DNA-Methyltransferase Gene
Single nucleotide polymorphisms (SNPs) in DNA repair genes could alter the transcriptional levels, structure and function of DNA repair proteins and alter DNA repair proficiency. Consequently, these SNPs could significantly influence the level of genetic damage, which is an early critical factor in …