Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"NMYC"”.
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The Role of Queuine Deficient tRNA in Translational Control
… and hypomodified tRNA. Two genes were used; Nmyc, an oncogene, and murine ornithine decarboxylase, a growth-related gene. These proteins are produced in quantity in cells with hypomodified tRNA and have been shown to be subject to translational controls. Rabbit globin mRNA was used as a …
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Persistant GATA2 Expression Promotes Self-Renewal of Myeloid Progenitors and Blocks Lymphoid Differentiation.
… the proliferation of these immortalized lines. Nmyc and HoxA9 mRNA were significantly higher in GATA2-ERT immortalized lines compared to control immortalized lines. Repression of either Nmyc or Hoxa9 in GATA2-ERT immortalized cells impaired their proliferation suggesting that they are potential …
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Role of Sonic Hedgehog in Development of the Central Nervous System
… of E-box on nestin 2nd intron 5’-region by Nmyc that is a target gene of Shh signaling. Shh also increased population and proliferation of neural stem cells in vitro or in vivo. In late stages, Shh induced specification of motor neurons as well as dopaminergic neurons. Simultaneously, Shh …
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Relationship between ¹²³l-metaiodobenzylguanidine (¹²³l-MIBG) imaging findings and outcome in patients with neuroblastoma at the Red Cross War Memorial Children's Hospital
… were located in the adrenal gland and half were NMYC amplified. Twenty (59%) patients died, 90% of deaths occurring in patients older than 12 months. No deaths were recorded in the 13 months after recruitment ended. The baseline CS did not predict outcome (alive or dead) or duration of survival. …
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Medulloblastoma: New animal models, preclinical drug testing, and characterising immune infiltrates
… immune-competent animal models of MYC- or NMYC-amplified medulloblastoma, (2) testing a novel treatment that combines conventional chemotherapies with a cell cycle checkpoint kinase inhibitor, and (3) investigating the effects of clinically used chemotherapies on immune cell populations in …