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Showing 1 to 1 of 1 for “"NMR, Integrins"”.
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Structural and Biochemical Characterization of the αI-domain, the Ligand Binding Domain, of Integrins αDβ2 and αXβ2
β2-integrins are among the most complex cell surface metallo-receptors known, and upon ligand binding, its ligand-binding domain (αI-domain) undergoes allosteric conformational changes. These “shape-shifting” events of the αI-domain are key to the mechanism of integrin action allowing …