Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"NMNAT2"”.
-
THE EFFECTS OF NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE 2 (NMNAT2) ON MOUSE NERVE AND BLADDER DEVELOPMENT
… to protect axons, but recent work has identified Nmnat2 as the endogenous factor involved in axon maintenance. Our goal is to identify the effects that Nmnat2 has on normal development. In this study, a randomly generated mutant was identified with a full knock-out of the Nmnat2 gene and a grossly …
-
Exploring the role of programmed axon death genes SARM1 and NMNAT2 in human disease
… and its upstream regulator, the pro-survival NMNAT2. Notably, complete removal of SARM1 has been shown to rescue injured axons permanently in one case and delay axon loss in many others, alleviating animal models of Parkinson’s disease, traumatic brain injury, glaucoma, and other disorders. …
-
Biochemical and Cellular Characterization of NMN Adenylyltransferase 2: A Brain Specific Isoform of an Essential NAD Synthesizing Enzyme
NMN adenylyltransferase 2 (Nmnat2) is one of three vertebrate enzymes that catalyze the synthesis of NAD from NMN and ATP. Nmnat1, -2 and -3 are each expressed from a separate gene and are distinguished from one another by their expression, subcellular localization and enzyme kinetics. Nmnat …
-
Chronic activation and downstream mechanisms of programmed axon death
… are the pro-survival NAD-synthesising enzyme NMNAT2, and the pro-degenerative NAD(P)-consuming enzyme SARM1. Over-expression of NMNAT enzymatic activity and removal of SARM1 can significantly delay axon degeneration following numerous neurodegenerative stressors in vitro and in several disease …
-
Programmed axon death as a driver of environmental neurotoxicity triggered by pyridine derivatives
… of upstream pathway regulators such as NMNAT2, or via cell body death mechanisms, while also triggering distinct SARM1 enzymatic activities. These findings suggest that SARM1 mediates environmental neurotoxicity and contributes to toxic neuropathies induced by various molecules through …
-
The role of the RNA-binding protein FUS in axonal organisation and disease
… mononucleotide adenylyltransferase 2 (NMNAT2), as its mRNA is a potential FUS binding target. I hypothesised that axonal NMNAT2 levels are sustained by LPS, as this protein is known to have a very short half-life. However, by combining in situ hybridisation and quantitative PCR …
-
Exploring SARM1 as a target to delay programmed axon degeneration
… that increasing levels of pro-survival factor NMNAT2, and removal of MYCBP2 involved in protein ubiquitination and turnover, or prodegenerative protein SARM1 can delay programmed axon degeneration. Preclinical studies indicate that complete genetic removal of Sarm1 leads to the strongest …