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Showing 1 to 20 of 42 for “"NMJ"”.

  1. The role of Lynx1, an endogenous modulator of cholinergic transmission, in NMJ development, maintenance, and repair

    Vaughan, Sydney KatherineVirginia Tech2019

    … and repair of mammalian neuromuscular junctions (NMJs) and skeletal muscles. Because of these essential actions, much effort has been devoted to identifying primary and auxiliary modulatory components of the cholinergic system at NMJs and throughout skeletal muscles. Here, I asked if Lynx1, a …

    vt Repository record

  2. Funktion der muskelspezifischen Kinase MuSK : Analyse im transgenen Tiermodell

    Henschel, OliverUniversität Heidelberg

    In der Entwicklung der neuromuskulären Synapse (NMJ) spielt die muskelspezifische Kinase (MuSK) eine zentrale Rolle. Die Expression der Acetylcholinrezeptoren (AChR) ist in den Muskelfasern während der Embryonalphase von MuSK abhängig, so dass MuSK-defiziente Tiere keine NMJ entwickelt haben und …

    heid-diss Repository record

  3. Effects of Heregulin on Muscle: A Biochemical and Histological Analysis

    Moss, Nicole Justine1970

    … has been shown to induce neuromuscular junction (NMJ) gene expression in vitro and improve skeletal muscle function in dystrophic mice. However, it is unclear if the HRG effects were due to proliferation, cell survival, differentiation, or stimulation of NMJ formation to improve …

    dominican Repository record

  4. COMPARATIVE STUDY ON DROSOPHILA LARVAL LOCOMOTION AND NEUROMUSCULAR JUNCTION MORPHOLOGY

    Yang, Emma YunyiCase Western Reserve University School of Graduate Studies2013

    … larval locomotion. Quantitative analyses on the NMJ anatomy reveal that the pattern of NMJ morphology correlates with larval locomotor behaviors, and suggests the observed differences in locomotion may be explained by variations in NMJ morphology. We also perform hybrid studies to investigate the …

    ohiolink Repository record

  5. Crimpy Sorts a BMP into the Regulated Secretory Pathway for Activity-Dependent Release in Drosophila Motorneurons

    James, Rebecca E.Case Western Reserve University School of Graduate Studies2013

    … at the Drosophila neuromuscular junction (NMJ). However the mechanisms that establish BMP pathway directionality and diversify pathway action in motorneurons remain elusive. In this thesis, I describe a novel regulator of the BMP signaling pathway in Drosophila motorneurons that I name …

    ohiolink Repository record

  6. Modulation der Aktivität des nikotinischen Acetylcholinrezeptors in transgenen Tiermodellen

    Peter, Jan ChristophUniversität Heidelberg

    … (AChR) der neuromuskulären Synapse (NMJ) können zu Veränderungen der Rezeptoreigenschaften, wie der Ligandenbindung und/oder der Kanalöffnung führen. Die daraus resultierenden Veränderungen des Endplattenpotentials können zu congenitalen myasthenischen Syndromen (CMS) führen, die als …

    heid-diss Repository record

  7. Roles Of Neuregulin1 In Neuromuscular Junction Development

    Wang, Jiajing2013

    <p>Neuromuscular junction (NMJ) development is a multistep process mediated by coordinated interactions between nerve terminals, target muscles, and peri-synaptic glial cells, and thus requires reciprocal signals derived from every cell type. Neuregulin1s (NRG1s) are a family of predominantly …

    wayne-thes Repository record

  8. Analysis of nerve terminal dysfunction in autoimmune neuropathy

    Morrison, IanUniversity of Glasgow2008

    … injury at mouse neuromuscular junctions (NMJs). Three antibodies (EG1, LB1 and R24) were identified as producing selective terminal Schwann cell (TSC) injury whilst sparing neuronal membranes at NMJs in BALB/c and C57BL/6 mouse strains in a dose dependent manner. These changes occur in the …

    glasgow Repository record

  9. MACROPHAGE RESPONSE TO INITIAL MUSCLE DENERVATION IN THE SOD1-G93A MOUSE MODEL OF AMYTROPHIC LATERAL SCLEROSIS.

    Gillespie, RachelWake Forest University2017

    … of MN to muscle at the neuromuscular junction (NMJ) underlies the characteristic muscle weakness seen in ALS. NMJs from fast-fatigable (FF) MNs preferentially denervate early in the disease process compared to fast-fatigue resistant (FR) and slow (S) NMJs. In the SOD1G93A mouse model of ALS, …

    wfu Repository record

  10. Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis

    Uwimpuhwe, HenrietteDepartment of Human Biology2009

    … receptors (AChR) of the neuromuscular junction (NMJ) block, alter or destroy their targets. The anti-AChR antibodies cause activation of the classical complement pathway leading to inflammatory injury at the NMJ. Decay Accelerating Factor (DAF), a member of complement regulatory proteins, …

    cape-town Repository record

  11. Neuron-Glial (NG) Interactions: A Microfluidic Examination of NG Emergent Responses for Repair

    Singh, Tanya2019

    … to the formation of neuromuscular junctions (NMJ) in the peripheral nervous system (PNS). The glial component of the NMJ, the Schwann cells (SCs), are essential to NMJ development and function including remodeling and regeneration. SCs are critical for PNS regeneration, where studies have …

    cuny Repository record

  12. Interaction between DVAP, the orthologue of human VAPB, and Drosophila Sac1

    Marescotti, ManuelaThe University of Edinburgh2013

    … at the Drosophila larval neuromuscular junction (NMJ), to control bouton morphology. In Pennetta’s lab Drosophila Sac1, a phosphoinositide-4- phosphate (PI4P) phosphatase, was identified during a genome-wide yeast twohybrid screen, as a DVAP binding partner. VAP plays a role in regulating PI4P …

    edinburgh Repository record

  13. The effect of whey protein-polyphenol on the recovery of muscle function and strength following eccentric exercise- the myogenic and neural contributions to eccentric exercise.

    Amy Booth (21038759)2026

    … Plasma agrin concentration, a proxy measure of NMJ function and integral to NMJ stability and integrity, in part via acetylcholine receptor clustering, also declined at 24h but did not differ between groups. In the subsequent study (Chapter 5), conducted in 19 recreationally active individuals …

    exeter

  14. Protons and Potentials: How Neurotransmission Influences and is Influenced by pH Transients

    Durbin, Ryan Joseph2025

    … junctions of the levator auris longus muscle (NMJ) and the central synapses in acute hippocampal brain slices. To characterize transients at the NMJ, I utilized a virally delivered, genetically encoded, pH-sensitive fluorescent probe, pHusion-Ex, to identify a novel activity-dependent pH …

    unr Repository record

  15. THE EFFECTS OF AGE, GH AND IGF-1 ON NEUROMUSCULAR RECOVERY FOLLOWING NERVE TRANSECTION

    Apel, Peter J.Wake Forest University2011

    … in the response of the neuromuscular junction (NMJ) to peripheral nerve injury. Using a dwarf rat model of GH-deficiency, it was found that a lack of circulating GH does not lead to impairments in neuromuscular recovery after nerve injury. Replenishment of GH in aged or GH-deficient rats does …

    wfu Repository record

  16. Force-extension of the Amylose Polysaccharide

    van den Berg, RudolfDepartment of Computer Science2009

    … receptors (AChR) of the neuromuscular junction (NMJ) block, alter or destroy their targets. The anti-AChR antibodies cause activation of the classical complement pathway leading to inflammatory injury at the NMJ. Decay Accelerating Factor (DAF), a member of complement regulatory proteins, …

    cape-town Repository record

  17. The Role of Edc3 in Drosophila Melanogaster Neuronal Development

    Zius, Keelan2025

    … at the larval neuromuscular junction (NMJ), providing the first evidence of a synaptic phenotype of Edc3 in any model system. To better understand how Edc3 regulates neurite morphogenesis in <em>Drosophila</em>, we performed RNA-sequencing and identified a subset of neuronal transcripts …

    denver Repository record

  18. Involvement of Gdap1 In The Regulation of Mtorc1 Activity In A Drosophila Mliv Model

    Clemons, Kristen, <p>https://orcid.org/0000-0001-9449-896X</p>2018

    … growth at the larval neuromuscular junction (NMJ), which is a cell biological readout for mTORC1 activity. We found that knocking down <em>GDAP1</em> expression can partially suppress the decreased phosphorylated S6K levels and rescue the reduced NMJ synaptic growth that occurs in MLIV<em> …

    uthsc Repository record

  19. Developing a Functional in Vitro Model of the Neuromuscular Interface

    Schwendeman, Laura A.Massachusetts Institute of Technology2025

    … system known as the neuromuscular junction (NMJ), which is the connection between skeletal muscle and motor neurons and is relevant in many neuromuscular degenerative diseases. This work identifies that current in vitro NMJ models are cohesively lacking the ability to support long-term, …

    mit Repository record

  20. Genetic analysis of synaptogyrin function in the synaptic vesicle cycle

    Stevens, Robin JMassachusetts Institute of Technology2012

    … terminal of the larval neuromuscular junction (NMJ). Drosophila lacking synaptogyrin are viable and fertile and have no overt deficits in motor function or courtship behavior. Ultrastructural analysis of mutant larvae revealed an increase in average synaptic vesicle diameter as well as enhanced …

    mit Repository record

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