Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"NMDARs"”.
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Probing spatial and subunit-dependent signalling by the NMDA receptor
NMDARs are ligand-gated cation channels which are activated by the neurotransmitter glutamate. NMDARs are essential in coupling electrical activity to biochemical signalling as a consequence of their high Ca2+ permeability. This Ca2+ influx acts as a secondary messenger to mediate neurodevelopment, …
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The induction of long-term potentiation attenuates kainic acid-induced excitotoxicity
… of N-methyl-D-aspartate glutamate receptors (NMDARs) is required for the long term potentiation (LTP) and long term depression (LTD) of excitatory synaptic transmission at hippocampal CA1 synapses, and plays an important role in learning and memory. In addition, it is accepted that the …
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A role for Dopamine neuron NMDA receptors in learning and decision-making
… predicted and actual reward. Knocking out NMDARs in dopamine neurons has been shown to attenuate dopaminergic phasic firing providing a potential model for delineating the functions of tonic and phasic dopamine. In order to study the role of dopamine neuron NMDARs in rewardcontingent …
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Distinct functional effects of NMDA receptors in normal and leukaemic megakaryocytes
… Ca2+-permeable N-methyl-D-aspartate receptors (NMDARs). Their involvement in megakaryocytic maturation has been shown in 2003 but details remain limited. The importance of Ca2+ homeostasis in malignant megakaryocytes has been further highlighted only in 2013 through the discovery of Calreticulin …
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Super-resolution imaging of glutamate receptors in cultured hippocampal neurons under basal and LTP conditions
… AMPA receptors (AMPARs) and NMDA receptors (NMDARs)—located on the postsynaptic membrane of nerve cells, are crucial for neuronal health, learning and memory formation. They can exist under basal condition where no synaptic strength change occurs, and chemically induced long-term potentiation …
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Identification of novel gating mechanisms underlying pharmacological potentiation of NMDA receptors
… mediated by N-methyl-D-aspartate receptors (NMDARs) is known to play an important role in synaptic plasticity, learning and memory. Moreover, NMDAR dysfunction may contribute to a variety of neuropsychiatric and neurological disorders including schizophrenia, epilepsy, stroke and trauma. …
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Role of GluN2C-containing NMDA Receptors in Cellular and Behavioral Deficits Associated with Corticothalamic Circuit Dysfunction in Schizophrenia
… demonstrate that deficit in GluN2C-containing NMDARs leads to schizophrenia-like phenotypes, and establish that pharmacologic enhancement of GluN2C-containing NMDARs may lead to beneficial effects for behavioral and cognitive deficits in schizophrenia.
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
… in glutamate spillover and activation of NMDARs. Further investigation showed that L-TBA-mediated activation of NMDARs was facilitated by the Mg2+ unblock of the receptor. Furthermore our data indicate that NMDAR signaling was controlled by the interplay between several factors, including …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
… in glutamate spillover and activation of NMDARs. Further investigation showed that L-TBA-mediated activation of NMDARs was facilitated by the Mg2+ unblock of the receptor. Furthermore our data indicate that NMDAR signaling was controlled by the interplay between several factors, including …
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Functions of GluN2D-containing NMDA receptors in dopamine neurons of the substantia nigra pars compacta
… activity in SNc-DA neurons. NMDA receptors (NMDARs) bind the excitatory neurotransmitter glutamate, and are essential for learning and memory. In SNc-DA neurons, NMDARs have a putative triheteromeric subunit arrangement of GluN1 plus GluN2B and/or GluN2D. Wild type (WT) mice, and those …
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Neuroprotection from the huntingtin-repressed transcriptional coactivator PGC-1α
… through extrasynaptic rather than synaptic NMDARs, leads to excitotoxic death in neurons and its regulation has been targeted in the search for therapeutic interventions for multiple neurological disorders. The data presented in this thesis show that the repression of PGC-1α by mtHtt may be …
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Mouse Models of GRIN1-Related Neurodevelopmental Disorder and Initial Investigations of Endocannabinoid Modulating Treatments
N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors formed as tetrameric complexes of two GluN1 subunits plus two copies of GluN2 or GluN3 subunits, or a mixture of both. These receptors mediate excitatory neurotransmission and play critical roles in processes underlying …
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Social isolation enhances calcium signaling and synaptic plasticity in dopamine neurons of the ventral tegmental area
… transmission in the VTA. Activation of NMDARs is critical to the generation of DA neuron bursts that encode rewards and reward-predictive cues, and NMDARs are necessary for associative reward learning. The isolation-induced enhancement of NMDAR LTP results from augmentation of …
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NMDAR-PSD95-nNOS Axis-Mediated Molecular Mechanisms in the Basolateral Amygdala Underlying Fear Consolidation
… of N-methyl-D-aspartic acid receptors (NMDARs). Stimulation of NMDARs recruits neuronal nitric oxide synthase (nNOS) to the synaptic scaffolding protein, postsynaptic density protein 95 (PSD95), to produce nitric oxide (NO). Our laboratory has previously shown that disruption of the …
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Targeting NMDA Receptors to Tune Corticothalamic Circuit Function
… underlying this phenomenon, including where NMDARs are localized at CT synapses and the effect of positive NMDAR modulators on nRT and VPM activity.
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RABPHILIN3A: FROM NMDA RECEPTOR MEMBRANE DYNAMICS TO NEURODEVELOPMENTAL DISORDERS
… of the NMDA-type glutamate receptors (NMDARs) at the cell surface, forming a ternary complex with the PSD-95 and GluN2A subunit of the receptor. This complex is needed for long-term potentiation (LTP) induction and NMDAR-dependent hippocampal behaviors, such as spatial learning. Under …
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The Master Synaptic Regulator: Activity Regulated Cytoskeleton Associated Protein, Arc, in Normal Aging and Diseases with Cognitive Impairment
… phosphorylate Arc following activation of the NMDARs and insulin receptor, respectively. Most importantly, we observed a reduced association of Arc with NMDARs accompanied by increased Arc linkage to FLNA during normal aging and in AD.</p> <p>The relevancy of the findings in mouse AD models is …
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Functional role of NMDA receptor subunit composition in metaplasticity
… and function of NMDA-type glutamate receptors (NMDARs). However, causality has not been conclusively established. Here we examined the mechanistic basis of metaplaticity, and specifically how this process is mediated by a switch in NMDAR subunit composition by focusing on the NR2A subunit of the …
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The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse
… as well as for the down regulation of synaptic NMDARs during postnatal development of the calyx of Held. In contrast, properties of the presynaptic release machinery and postsynaptic AMPARs are unaffected by chronic changes in the level of afferent activity at this synapse.
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Linking dopaminergic physiology to working memory related neural circuitry
… of schizophrenia, and drugs that target NMDARs induce schizophrenia-like symptoms in healthy individuals. In this thesis, I seek to further examine the possible connection between NMDA receptors, the dopamine system, and schizophrenia-related working memory deficits. We find that …
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