Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"NMDA receptor antagonists"”.
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Effects of NMDA Receptor Antagonists on the Differential-Reinforcement-of-Low-Rate 72 Second (DRL 72) Responding in Rats
<p>The noncompetitive NMDA receptor antagonist dextromethorphan and its metabolite dextrorphan have widespread effects on the central nervous system. Dextromethorphan alone and with quinidine (a CYP-450 2D6 inhibitor) have been shown to produce antidepressant effects in preclinical and clinical …
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Pharmacological and Non-pharmacological Prevention of Fentanyl-Induced Cough : A meta-analysis
… (CI) 0.21 – 0.39], N-methyl-D-aspartate (NMDA) receptor antagonists [OR = 0.09, 95% CI 0.02 – 0.42], propofol [OR = 0.07, 95% CI 0.01 – 0.36], α2 agonists [OR = 0.32, 95% CI 0.21 – 0.48], β2 agonists [OR = 0.10, 95% CI 0.03 – 0.30], fentanyl priming [OR = 0.33, 95% CI 0.19 – 0.56], and …
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EFFECTS OF SIGMA-1 RECEPTOR AGONISTS ON COMPULSIVE BEHAVIOR AND NEUROPLASTICITY
… (mTOR). Preclinical studies suggest that sigma-1 receptor agonists produce antidepressant-like drug effects and affect the mTOR pathway. Other mechanisms include serotonin neurotransmission and N-methyl-D-aspartate (NMDA) receptors. This study evaluated drugs acting as sigma-1 agonists, NMDA …
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Glutamate Excitotoxicty Activates a Novel Calcium Permeable Ion Channel in Cultured Hippocampal Neurons
… brain injury and ALS. Excessive stimulation of NMDA subtypes of glutamate receptors leads to protracted intracellular calcium elevations triggering calcium mediated neurotoxic mechanisms culminating in delayed neuronal cell death. In addition, glutamate excitotoxicity induces a NMDA dependent …
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Excitotoxic Injury Mechanisms in Central White Matter
… in central WM and examines the hypothesis that NMDA receptor over-activation mediates ischemic myelin damage. Using glutamate biosensor microelectrodes and FM-dye imaging, I show that axonal depolarisation in the adult corpus callosum evokes rapid vesicular docking in axons, capable of elevating …
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Ionic dysregulation in white matter damage
… attention was paid to consequences of glutamate receptor activity. Using the oxygen glucose deprivation model of ischaemia, in the mouse brain slice, it was found that ischaemia-induced potassium release is greater in cortical grey than in corpus callosum white matter. This distinction is …
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The Effects of Repeated Ketamine Administration During Adolescence on Anxiety and Depressive-like Behaviors Induced by a Predator Odor
… its rapid effects. Ketamine is a noncompetitive NMDA receptor antagonist that stimulates glutamate transmission. The efficacy of non-competitive NMDA receptor antagonists in anxiety treatment, however, lacks consistent findings. The goal of the present study was to examine the effects of repeated …
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An assessment of reconsolidation blockade to disrupt memories relevant to psychiatric disorders
… of the resultant process, reconsolidation, with NMDA receptor antagonists or protein synthesis inhibition can lead to a decrease in subsequent memory expression. This may offer a potential tool for the treatment of psychiatric disorders characterised by maladaptive memories, including drug …
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Investigation of Monoaminergic Neurotransmitter Systems as a Method to Study Alzheimer's Disease-Related Neurodegeneration
… inhibitors and N-methyl-D¬-aspartate (NMDA) receptor antagonists, however, these medications only provide mild symptomatic benefits in a subset of AD patients. A great deal of work aimed at understanding the ongoing pathological processes in AD and its progression have resulted in a …